The Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery

ABSTRACT Bacteria have supplied us with many bioactive molecules for use in medicine and agriculture. However, rates of discovery have decreased as the biosynthetic capacity of the culturable biosphere has been continuously mined for many decades. The as-yet-uncultured biosphere is likely to hold fa...

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Autor principal:	Jason C. Kwan
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	genome reduction metagenomics metatranscriptomics natural products/secondary metabolites symbiosis synthetic biology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c96c812df2684acdade47691a0ef47cc
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spelling	oai:doaj.org-article:c96c812df2684acdade47691a0ef47cc2021-12-02T19:47:34ZThe Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery10.1128/mSystems.00186-172379-5077https://doaj.org/article/c96c812df2684acdade47691a0ef47cc2018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00186-17https://doaj.org/toc/2379-5077ABSTRACT Bacteria have supplied us with many bioactive molecules for use in medicine and agriculture. However, rates of discovery have decreased as the biosynthetic capacity of the culturable biosphere has been continuously mined for many decades. The as-yet-uncultured biosphere is likely to hold far greater biosynthetic potential, especially where ecological niches favor the selection of therapeutically useful bioactivities. I outline here how metagenomics and other systems biology approaches can be used to gain insight into small-molecule biosynthesis and the selective forces which shape it. I also argue that we need a greater understanding of the function of small molecules in complex microbiomes and rational synthetic biology methods to functionally reconstruct large biosynthetic pathways in heterologous hosts.Jason C. KwanAmerican Society for Microbiologyarticlegenome reductionmetagenomicsmetatranscriptomicsnatural products/secondary metabolitessymbiosissynthetic biologyMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	genome reduction metagenomics metatranscriptomics natural products/secondary metabolites symbiosis synthetic biology Microbiology QR1-502
spellingShingle	genome reduction metagenomics metatranscriptomics natural products/secondary metabolites symbiosis synthetic biology Microbiology QR1-502 Jason C. Kwan The Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery
description	ABSTRACT Bacteria have supplied us with many bioactive molecules for use in medicine and agriculture. However, rates of discovery have decreased as the biosynthetic capacity of the culturable biosphere has been continuously mined for many decades. The as-yet-uncultured biosphere is likely to hold far greater biosynthetic potential, especially where ecological niches favor the selection of therapeutically useful bioactivities. I outline here how metagenomics and other systems biology approaches can be used to gain insight into small-molecule biosynthesis and the selective forces which shape it. I also argue that we need a greater understanding of the function of small molecules in complex microbiomes and rational synthetic biology methods to functionally reconstruct large biosynthetic pathways in heterologous hosts.
format	article
author	Jason C. Kwan
author_facet	Jason C. Kwan
author_sort	Jason C. Kwan
title	The Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery
title_short	The Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery
title_full	The Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery
title_fullStr	The Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery
title_full_unstemmed	The Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery
title_sort	who, why, and how of small-molecule production in invertebrate microbiomes: basic insights fueling drug discovery
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/c96c812df2684acdade47691a0ef47cc
work_keys_str_mv	AT jasonckwan thewhowhyandhowofsmallmoleculeproductionininvertebratemicrobiomesbasicinsightsfuelingdrugdiscovery AT jasonckwan whowhyandhowofsmallmoleculeproductionininvertebratemicrobiomesbasicinsightsfuelingdrugdiscovery
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The Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery

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