Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients

Recent studies have shown the effects of vitamin D on host response to infectious diseases. Some studies detected a high prevalence of hypovitaminosis D in HIV-infected patients, but scarce information exists for HTLV-1 infection. We conducted a cross-sectional study to evaluate the frequency of hyp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elaine Coutinho Netto, Alfredo Carlos Silva, Célia Pedroso, Carlos Brites
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	25(OH)D vitamin D HTLV Calcitriol HAM/TSP Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c9711afeb27f4057acfa027ac2822585
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c9711afeb27f4057acfa027ac2822585
record_format	dspace
spelling	oai:doaj.org-article:c9711afeb27f4057acfa027ac28225852021-11-25T19:13:28ZHypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients10.3390/v131122231999-4915https://doaj.org/article/c9711afeb27f4057acfa027ac28225852021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2223https://doaj.org/toc/1999-4915Recent studies have shown the effects of vitamin D on host response to infectious diseases. Some studies detected a high prevalence of hypovitaminosis D in HIV-infected patients, but scarce information exists for HTLV-1 infection. We conducted a cross-sectional study to evaluate the frequency of hypovitaminosis D in HTLV-1 patients and its relationship with their immune response in HTLV-infected patients and in age- and gender-matched controls at a Brazilian rehabilitation hospital. We compared vitamin D, interleukin-6 (IL-6), tumoral necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) levels across groups. Logistic regression was utilized to assess the association between hypovitaminosis D and cytokine levels. We enrolled 161 HTLV-infected subjects (129 HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, 32 asymptomatic HTLV carriers) and equal number of HTLV-negative controls. We observed a significantly higher prevalence of hypovitaminosis D in patients with HAM/TSP than in HTLV asymptomatic carriers (<i>p</i> < 0.001), or controls (<i>p</i> < 0.001). HAM/TSP patients also had higher levels of IL-6 and IFN-γ than asymptomatic carriers. Patients with HAM/TSP and hypovitaminosis D had higher levels of TNF-α than asymptomatic HTLV carriers. These findings suggest hypovitaminosis D plays a role in HAM/TSP pathogenesis, and it needs to be evaluated in further studies.Elaine Coutinho NettoAlfredo Carlos SilvaCélia PedrosoCarlos BritesMDPI AGarticle25(OH)Dvitamin DHTLVCalcitriolHAM/TSPMicrobiologyQR1-502ENViruses, Vol 13, Iss 2223, p 2223 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	25(OH)D vitamin D HTLV Calcitriol HAM/TSP Microbiology QR1-502
spellingShingle	25(OH)D vitamin D HTLV Calcitriol HAM/TSP Microbiology QR1-502 Elaine Coutinho Netto Alfredo Carlos Silva Célia Pedroso Carlos Brites Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients
description	Recent studies have shown the effects of vitamin D on host response to infectious diseases. Some studies detected a high prevalence of hypovitaminosis D in HIV-infected patients, but scarce information exists for HTLV-1 infection. We conducted a cross-sectional study to evaluate the frequency of hypovitaminosis D in HTLV-1 patients and its relationship with their immune response in HTLV-infected patients and in age- and gender-matched controls at a Brazilian rehabilitation hospital. We compared vitamin D, interleukin-6 (IL-6), tumoral necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) levels across groups. Logistic regression was utilized to assess the association between hypovitaminosis D and cytokine levels. We enrolled 161 HTLV-infected subjects (129 HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, 32 asymptomatic HTLV carriers) and equal number of HTLV-negative controls. We observed a significantly higher prevalence of hypovitaminosis D in patients with HAM/TSP than in HTLV asymptomatic carriers (<i>p</i> < 0.001), or controls (<i>p</i> < 0.001). HAM/TSP patients also had higher levels of IL-6 and IFN-γ than asymptomatic carriers. Patients with HAM/TSP and hypovitaminosis D had higher levels of TNF-α than asymptomatic HTLV carriers. These findings suggest hypovitaminosis D plays a role in HAM/TSP pathogenesis, and it needs to be evaluated in further studies.
format	article
author	Elaine Coutinho Netto Alfredo Carlos Silva Célia Pedroso Carlos Brites
author_facet	Elaine Coutinho Netto Alfredo Carlos Silva Célia Pedroso Carlos Brites
author_sort	Elaine Coutinho Netto
title	Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients
title_short	Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients
title_full	Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients
title_fullStr	Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients
title_full_unstemmed	Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients
title_sort	hypovitaminosis d is associated with higher levels of inflammatory cytokines and with ham/tsp in htlv-infected patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c9711afeb27f4057acfa027ac2822585
work_keys_str_mv	AT elainecoutinhonetto hypovitaminosisdisassociatedwithhigherlevelsofinflammatorycytokinesandwithhamtspinhtlvinfectedpatients AT alfredocarlossilva hypovitaminosisdisassociatedwithhigherlevelsofinflammatorycytokinesandwithhamtspinhtlvinfectedpatients AT celiapedroso hypovitaminosisdisassociatedwithhigherlevelsofinflammatorycytokinesandwithhamtspinhtlvinfectedpatients AT carlosbrites hypovitaminosisdisassociatedwithhigherlevelsofinflammatorycytokinesandwithhamtspinhtlvinfectedpatients
_version_	1718410182839500800

Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients

Ejemplares similares