An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload

Abstract Right ventricular (RV) remodeling and longitudinal fiber reorientation in the setting of pulmonary hypertension (PH) affects ventricular structure and function, eventually leading to RV failure. Characterizing the kinematics of myocardial fibers helps better understanding the underlying mec...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Danial Sharifi Kia, Ronald Fortunato, Spandan Maiti, Marc A. Simon, Kang Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9714d700c5a4254b8ab72da748b3845
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c9714d700c5a4254b8ab72da748b3845
record_format	dspace
spelling	oai:doaj.org-article:c9714d700c5a4254b8ab72da748b38452021-12-02T14:27:02ZAn exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload10.1038/s41598-021-83154-82045-2322https://doaj.org/article/c9714d700c5a4254b8ab72da748b38452021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83154-8https://doaj.org/toc/2045-2322Abstract Right ventricular (RV) remodeling and longitudinal fiber reorientation in the setting of pulmonary hypertension (PH) affects ventricular structure and function, eventually leading to RV failure. Characterizing the kinematics of myocardial fibers helps better understanding the underlying mechanisms of fiber realignment in PH. In the current work, high-frequency ultrasound imaging and structurally-informed finite element (FE) models were employed for an exploratory evaluation of the stretch-induced kinematics of RV fibers. Image-based experimental evaluation of fiber kinematics in porcine myocardium revealed the capability of affine assumptions to effectively approximate myofiber realignment in the RV free wall. The developed imaging framework provides a noninvasive modality to quantify transmural RV myofiber kinematics in large animal models. FE modeling results demonstrated that chronic pressure overload, but not solely an acute rise in pressures, results in kinematic shift of RV fibers towards the longitudinal direction. Additionally, FE simulations suggest a potential protective role for concentric hypertrophy (increased wall thickness) against fiber reorientation, while eccentric hypertrophy (RV dilation) resulted in longitudinal fiber realignment. Our study improves the current understanding of the role of different remodeling events involved in transmural myofiber reorientation in PH. Future experimentations are warranted to test the model-generated hypotheses.Danial Sharifi KiaRonald FortunatoSpandan MaitiMarc A. SimonKang KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Danial Sharifi Kia Ronald Fortunato Spandan Maiti Marc A. Simon Kang Kim An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload
description	Abstract Right ventricular (RV) remodeling and longitudinal fiber reorientation in the setting of pulmonary hypertension (PH) affects ventricular structure and function, eventually leading to RV failure. Characterizing the kinematics of myocardial fibers helps better understanding the underlying mechanisms of fiber realignment in PH. In the current work, high-frequency ultrasound imaging and structurally-informed finite element (FE) models were employed for an exploratory evaluation of the stretch-induced kinematics of RV fibers. Image-based experimental evaluation of fiber kinematics in porcine myocardium revealed the capability of affine assumptions to effectively approximate myofiber realignment in the RV free wall. The developed imaging framework provides a noninvasive modality to quantify transmural RV myofiber kinematics in large animal models. FE modeling results demonstrated that chronic pressure overload, but not solely an acute rise in pressures, results in kinematic shift of RV fibers towards the longitudinal direction. Additionally, FE simulations suggest a potential protective role for concentric hypertrophy (increased wall thickness) against fiber reorientation, while eccentric hypertrophy (RV dilation) resulted in longitudinal fiber realignment. Our study improves the current understanding of the role of different remodeling events involved in transmural myofiber reorientation in PH. Future experimentations are warranted to test the model-generated hypotheses.
format	article
author	Danial Sharifi Kia Ronald Fortunato Spandan Maiti Marc A. Simon Kang Kim
author_facet	Danial Sharifi Kia Ronald Fortunato Spandan Maiti Marc A. Simon Kang Kim
author_sort	Danial Sharifi Kia
title	An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload
title_short	An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload
title_full	An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload
title_fullStr	An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload
title_full_unstemmed	An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload
title_sort	exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9714d700c5a4254b8ab72da748b3845
work_keys_str_mv	AT danialsharifikia anexploratoryassessmentofstretchinducedtransmuralmyocardialfiberkinematicsinrightventricularpressureoverload AT ronaldfortunato anexploratoryassessmentofstretchinducedtransmuralmyocardialfiberkinematicsinrightventricularpressureoverload AT spandanmaiti anexploratoryassessmentofstretchinducedtransmuralmyocardialfiberkinematicsinrightventricularpressureoverload AT marcasimon anexploratoryassessmentofstretchinducedtransmuralmyocardialfiberkinematicsinrightventricularpressureoverload AT kangkim anexploratoryassessmentofstretchinducedtransmuralmyocardialfiberkinematicsinrightventricularpressureoverload AT danialsharifikia exploratoryassessmentofstretchinducedtransmuralmyocardialfiberkinematicsinrightventricularpressureoverload AT ronaldfortunato exploratoryassessmentofstretchinducedtransmuralmyocardialfiberkinematicsinrightventricularpressureoverload AT spandanmaiti exploratoryassessmentofstretchinducedtransmuralmyocardialfiberkinematicsinrightventricularpressureoverload AT marcasimon exploratoryassessmentofstretchinducedtransmuralmyocardialfiberkinematicsinrightventricularpressureoverload AT kangkim exploratoryassessmentofstretchinducedtransmuralmyocardialfiberkinematicsinrightventricularpressureoverload
_version_	1718391337955360768

An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload

Ejemplares similares