Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles

Durable response rate to anti-PD-1/PD-L1 therapy remains relatively low in patients with cancer. Here the authors show that metformin-loaded mannose-modified macrophage-derived microparticles reprogram the tumor immune microenvironment and improve responses to anti-PD-1 therapy.

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Detalles Bibliográficos
Autores principales:	Zhaohan Wei, Xiaoqiong Zhang, Tuying Yong, Nana Bie, Guiting Zhan, Xin Li, Qingle Liang, Jianye Li, Jingjing Yu, Gang Huang, Yuchen Yan, Zelong Zhang, Bixiang Zhang, Lu Gan, Bo Huang, Xiangliang Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c971cb339bd0453ca49a321d5bcad548
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spelling	oai:doaj.org-article:c971cb339bd0453ca49a321d5bcad5482021-12-02T13:56:46ZBoosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles10.1038/s41467-020-20723-x2041-1723https://doaj.org/article/c971cb339bd0453ca49a321d5bcad5482021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20723-xhttps://doaj.org/toc/2041-1723Durable response rate to anti-PD-1/PD-L1 therapy remains relatively low in patients with cancer. Here the authors show that metformin-loaded mannose-modified macrophage-derived microparticles reprogram the tumor immune microenvironment and improve responses to anti-PD-1 therapy.Zhaohan WeiXiaoqiong ZhangTuying YongNana BieGuiting ZhanXin LiQingle LiangJianye LiJingjing YuGang HuangYuchen YanZelong ZhangBixiang ZhangLu GanBo HuangXiangliang YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhaohan Wei Xiaoqiong Zhang Tuying Yong Nana Bie Guiting Zhan Xin Li Qingle Liang Jianye Li Jingjing Yu Gang Huang Yuchen Yan Zelong Zhang Bixiang Zhang Lu Gan Bo Huang Xiangliang Yang Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
description	Durable response rate to anti-PD-1/PD-L1 therapy remains relatively low in patients with cancer. Here the authors show that metformin-loaded mannose-modified macrophage-derived microparticles reprogram the tumor immune microenvironment and improve responses to anti-PD-1 therapy.
format	article
author	Zhaohan Wei Xiaoqiong Zhang Tuying Yong Nana Bie Guiting Zhan Xin Li Qingle Liang Jianye Li Jingjing Yu Gang Huang Yuchen Yan Zelong Zhang Bixiang Zhang Lu Gan Bo Huang Xiangliang Yang
author_facet	Zhaohan Wei Xiaoqiong Zhang Tuying Yong Nana Bie Guiting Zhan Xin Li Qingle Liang Jianye Li Jingjing Yu Gang Huang Yuchen Yan Zelong Zhang Bixiang Zhang Lu Gan Bo Huang Xiangliang Yang
author_sort	Zhaohan Wei
title	Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
title_short	Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
title_full	Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
title_fullStr	Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
title_full_unstemmed	Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
title_sort	boosting anti-pd-1 therapy with metformin-loaded macrophage-derived microparticles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c971cb339bd0453ca49a321d5bcad548
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Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles

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