Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing

Information on immune receptor repertoire provides important insights on disease progression and therapy development, but can be expensive and time-consuming to obtain. Here the authors report ImReP, a computational method that can extract detailed immune repertoire information from existing tissue-...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Igor Mandric, Jeremy Rotman, Harry Taegyun Yang, Nicolas Strauli, Dennis J. Montoya, William Van Der Wey, Jiem R. Ronas, Benjamin Statz, Douglas Yao, Velislava Petrova, Alex Zelikovsky, Roberto Spreafico, Sagiv Shifman, Noah Zaitlen, Maura Rossetti, K. Mark Ansel, Eleazar Eskin, Serghei Mangul
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c97227d196d24e78bdaa9613ff7b0b70
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c97227d196d24e78bdaa9613ff7b0b70
record_format	dspace
spelling	oai:doaj.org-article:c97227d196d24e78bdaa9613ff7b0b702021-12-02T17:40:05ZProfiling immunoglobulin repertoires across multiple human tissues using RNA sequencing10.1038/s41467-020-16857-72041-1723https://doaj.org/article/c97227d196d24e78bdaa9613ff7b0b702020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16857-7https://doaj.org/toc/2041-1723Information on immune receptor repertoire provides important insights on disease progression and therapy development, but can be expensive and time-consuming to obtain. Here the authors report ImReP, a computational method that can extract detailed immune repertoire information from existing tissue-specific RNA sequencing data.Igor MandricJeremy RotmanHarry Taegyun YangNicolas StrauliDennis J. MontoyaWilliam Van Der WeyJiem R. RonasBenjamin StatzDouglas YaoVelislava PetrovaAlex ZelikovskyRoberto SpreaficoSagiv ShifmanNoah ZaitlenMaura RossettiK. Mark AnselEleazar EskinSerghei MangulNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Igor Mandric Jeremy Rotman Harry Taegyun Yang Nicolas Strauli Dennis J. Montoya William Van Der Wey Jiem R. Ronas Benjamin Statz Douglas Yao Velislava Petrova Alex Zelikovsky Roberto Spreafico Sagiv Shifman Noah Zaitlen Maura Rossetti K. Mark Ansel Eleazar Eskin Serghei Mangul Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing
description	Information on immune receptor repertoire provides important insights on disease progression and therapy development, but can be expensive and time-consuming to obtain. Here the authors report ImReP, a computational method that can extract detailed immune repertoire information from existing tissue-specific RNA sequencing data.
format	article
author	Igor Mandric Jeremy Rotman Harry Taegyun Yang Nicolas Strauli Dennis J. Montoya William Van Der Wey Jiem R. Ronas Benjamin Statz Douglas Yao Velislava Petrova Alex Zelikovsky Roberto Spreafico Sagiv Shifman Noah Zaitlen Maura Rossetti K. Mark Ansel Eleazar Eskin Serghei Mangul
author_facet	Igor Mandric Jeremy Rotman Harry Taegyun Yang Nicolas Strauli Dennis J. Montoya William Van Der Wey Jiem R. Ronas Benjamin Statz Douglas Yao Velislava Petrova Alex Zelikovsky Roberto Spreafico Sagiv Shifman Noah Zaitlen Maura Rossetti K. Mark Ansel Eleazar Eskin Serghei Mangul
author_sort	Igor Mandric
title	Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing
title_short	Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing
title_full	Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing
title_fullStr	Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing
title_full_unstemmed	Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing
title_sort	profiling immunoglobulin repertoires across multiple human tissues using rna sequencing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c97227d196d24e78bdaa9613ff7b0b70
work_keys_str_mv	AT igormandric profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT jeremyrotman profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT harrytaegyunyang profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT nicolasstrauli profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT dennisjmontoya profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT williamvanderwey profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT jiemrronas profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT benjaminstatz profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT douglasyao profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT velislavapetrova profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT alexzelikovsky profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT robertospreafico profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT sagivshifman profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT noahzaitlen profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT maurarossetti profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT kmarkansel profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT eleazareskin profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing AT sergheimangul profilingimmunoglobulinrepertoiresacrossmultiplehumantissuesusingrnasequencing
_version_	1718379789610385408

Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing

Ejemplares similares