Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity

Adipose tissue expresses all the renin-angiotensin system (RAS) components that play an important role in the adipogenesis, lipid and glucose metabolism regulation in an auto/paracrine manner. The classical RAS has been found to be over-activated during the adipose tissue enlargement, thus elevated...

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Autores principales:	Slamkova M, Zorad S, Krskova K
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	angiotensin-(1-7) mas receptor (pro)renin receptor angiotensin iv adipose tissue obesity insulin resistance Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/c9772e1bc23f4e25a8f307121827b75c
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spelling	oai:doaj.org-article:c9772e1bc23f4e25a8f307121827b75c2021-12-02T15:29:47ZAlternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity1336-032910.1515/enr-2016-0025https://doaj.org/article/c9772e1bc23f4e25a8f307121827b75c2016-10-01T00:00:00Zhttps://doi.org/10.1515/enr-2016-0025https://doaj.org/toc/1336-0329Adipose tissue expresses all the renin-angiotensin system (RAS) components that play an important role in the adipogenesis, lipid and glucose metabolism regulation in an auto/paracrine manner. The classical RAS has been found to be over-activated during the adipose tissue enlargement, thus elevated generation of angiotensin II (Ang II) may contribute to the obesity pathogenesis. The contemporary view on the RAS has become more complex with the discovery of alternative pathways, including angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor, (pro)renin receptor, as well as angiotensin IV(Ang IV)/AT4 receptor. Ang-(1-7) via Mas receptor counteracts with most of the deleterious effects of the Ang II-mediated by AT1 receptor implying its beneficial role in the glucose and lipid metabolism, oxidative stress, inflammation, and insulin resistance. Pro(renin) receptor may play a role (at least partial) in the pathogenesis of the obesity by increasing the local production of Ang II in adipose tissue as well as triggering signal transduction independently of Ang II. In this review, modulation of alternative RAS pathways in adipose tissue during obesity is discussed and the involvement of Ang-(1-7), (pro)renin and AT4 receptors in the regulation of adipose tissue homeostasis and insulin resistance is summarized.Slamkova MZorad SKrskova KSciendoarticleangiotensin-(1-7)mas receptor(pro)renin receptorangiotensin ivadipose tissueobesityinsulin resistanceDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 50, Iss 4, Pp 229-240 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	angiotensin-(1-7) mas receptor (pro)renin receptor angiotensin iv adipose tissue obesity insulin resistance Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	angiotensin-(1-7) mas receptor (pro)renin receptor angiotensin iv adipose tissue obesity insulin resistance Diseases of the endocrine glands. Clinical endocrinology RC648-665 Slamkova M Zorad S Krskova K Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity
description	Adipose tissue expresses all the renin-angiotensin system (RAS) components that play an important role in the adipogenesis, lipid and glucose metabolism regulation in an auto/paracrine manner. The classical RAS has been found to be over-activated during the adipose tissue enlargement, thus elevated generation of angiotensin II (Ang II) may contribute to the obesity pathogenesis. The contemporary view on the RAS has become more complex with the discovery of alternative pathways, including angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor, (pro)renin receptor, as well as angiotensin IV(Ang IV)/AT4 receptor. Ang-(1-7) via Mas receptor counteracts with most of the deleterious effects of the Ang II-mediated by AT1 receptor implying its beneficial role in the glucose and lipid metabolism, oxidative stress, inflammation, and insulin resistance. Pro(renin) receptor may play a role (at least partial) in the pathogenesis of the obesity by increasing the local production of Ang II in adipose tissue as well as triggering signal transduction independently of Ang II. In this review, modulation of alternative RAS pathways in adipose tissue during obesity is discussed and the involvement of Ang-(1-7), (pro)renin and AT4 receptors in the regulation of adipose tissue homeostasis and insulin resistance is summarized.
format	article
author	Slamkova M Zorad S Krskova K
author_facet	Slamkova M Zorad S Krskova K
author_sort	Slamkova M
title	Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity
title_short	Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity
title_full	Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity
title_fullStr	Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity
title_full_unstemmed	Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity
title_sort	alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/c9772e1bc23f4e25a8f307121827b75c
work_keys_str_mv	AT slamkovam alternativereninangiotensinsystempathwaysinadiposetissueandtheirroleinthepathogenesisofobesity AT zorads alternativereninangiotensinsystempathwaysinadiposetissueandtheirroleinthepathogenesisofobesity AT krskovak alternativereninangiotensinsystempathwaysinadiposetissueandtheirroleinthepathogenesisofobesity
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Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity

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