Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study

We aimed to examine the association between metabolic syndrome and the risk of kidney stone development in a large-scale community-based cohort. A total of 121,579 participants enrolled in the Taiwan Biobank were analyzed. They were divided into two groups on the basis of presence of metabolic syndr...

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Autores principales:	Che-Wei Chang, Hung-Lung Ke, Jia-In Lee, Yung-Chin Lee, Jhen-Hao Jhan, Hsun-Shuan Wang, Jung-Tsung Shen, Yao-Hsuan Tsao, Shu-Pin Huang, Jiun-Hung Geng
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	epidemiologic study longitudinal study kidney stone metabolic syndrome risk factors diabetes mellitus Medicine R
Acceso en línea:	https://doaj.org/article/c9779d06ef5042d3b12e6a6f4df08c06
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spelling	oai:doaj.org-article:c9779d06ef5042d3b12e6a6f4df08c062021-11-25T18:07:36ZMetabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study10.3390/jpm111111542075-4426https://doaj.org/article/c9779d06ef5042d3b12e6a6f4df08c062021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1154https://doaj.org/toc/2075-4426We aimed to examine the association between metabolic syndrome and the risk of kidney stone development in a large-scale community-based cohort. A total of 121,579 participants enrolled in the Taiwan Biobank were analyzed. They were divided into two groups on the basis of presence of metabolic syndrome. The presence of kidney stone disease was defined by self-reported history of kidney stones. The mean age of participants was 50 years old, and self-reported kidney stones were observed in 3446 (10%) and 4292 (5%) participants with metabolic syndrome and without metabolic syndrome, respectively. Higher prevalence of kidney stone disease was found in participants with metabolic syndrome compared to those without metabolic syndrome (odds ratio (OR), 1.32; 95% confidence interval (95% CI), 1.25 to 1.39). In addition, the risk of incident kidney stone development was analyzed in a longitudinal cohort of 25,263 participants without kidney stones at baseline during a mean follow-up of 47 months. Multivariable Cox regression analysis revealed that the risk for incident kidney stone disease was higher in participants with metabolic syndrome than those without metabolic syndrome (hazard ratio, 1.24; 95% CI, 1.04 to 1.49). Our study suggests that metabolic syndrome does increase the risk of kidney stones.Che-Wei ChangHung-Lung KeJia-In LeeYung-Chin LeeJhen-Hao JhanHsun-Shuan WangJung-Tsung ShenYao-Hsuan TsaoShu-Pin HuangJiun-Hung GengMDPI AGarticleepidemiologic studylongitudinal studykidney stonemetabolic syndromerisk factorsdiabetes mellitusMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1154, p 1154 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epidemiologic study longitudinal study kidney stone metabolic syndrome risk factors diabetes mellitus Medicine R
spellingShingle	epidemiologic study longitudinal study kidney stone metabolic syndrome risk factors diabetes mellitus Medicine R Che-Wei Chang Hung-Lung Ke Jia-In Lee Yung-Chin Lee Jhen-Hao Jhan Hsun-Shuan Wang Jung-Tsung Shen Yao-Hsuan Tsao Shu-Pin Huang Jiun-Hung Geng Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study
description	We aimed to examine the association between metabolic syndrome and the risk of kidney stone development in a large-scale community-based cohort. A total of 121,579 participants enrolled in the Taiwan Biobank were analyzed. They were divided into two groups on the basis of presence of metabolic syndrome. The presence of kidney stone disease was defined by self-reported history of kidney stones. The mean age of participants was 50 years old, and self-reported kidney stones were observed in 3446 (10%) and 4292 (5%) participants with metabolic syndrome and without metabolic syndrome, respectively. Higher prevalence of kidney stone disease was found in participants with metabolic syndrome compared to those without metabolic syndrome (odds ratio (OR), 1.32; 95% confidence interval (95% CI), 1.25 to 1.39). In addition, the risk of incident kidney stone development was analyzed in a longitudinal cohort of 25,263 participants without kidney stones at baseline during a mean follow-up of 47 months. Multivariable Cox regression analysis revealed that the risk for incident kidney stone disease was higher in participants with metabolic syndrome than those without metabolic syndrome (hazard ratio, 1.24; 95% CI, 1.04 to 1.49). Our study suggests that metabolic syndrome does increase the risk of kidney stones.
format	article
author	Che-Wei Chang Hung-Lung Ke Jia-In Lee Yung-Chin Lee Jhen-Hao Jhan Hsun-Shuan Wang Jung-Tsung Shen Yao-Hsuan Tsao Shu-Pin Huang Jiun-Hung Geng
author_facet	Che-Wei Chang Hung-Lung Ke Jia-In Lee Yung-Chin Lee Jhen-Hao Jhan Hsun-Shuan Wang Jung-Tsung Shen Yao-Hsuan Tsao Shu-Pin Huang Jiun-Hung Geng
author_sort	Che-Wei Chang
title	Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study
title_short	Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study
title_full	Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study
title_fullStr	Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study
title_full_unstemmed	Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study
title_sort	metabolic syndrome increases the risk of kidney stone disease: a cross-sectional and longitudinal cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c9779d06ef5042d3b12e6a6f4df08c06
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Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study

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