Linking obesity with type 2 diabetes: the role of T-bet

Jibran A Wali,1,2 Helen E Thomas,1,2 Andrew PR Sutherland1 1Immunology and Diabetes Unit, St Vincent's Institute, 2Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia Abstract: Obesity is a major predisposing factor for the developme...

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Autores principales:	Wali JA, Thomas HE, Sutherl, APR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c97d28937cf640169300b4825124a9d9
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spelling	oai:doaj.org-article:c97d28937cf640169300b4825124a9d92021-12-02T01:58:00ZLinking obesity with type 2 diabetes: the role of T-bet1178-7007https://doaj.org/article/c97d28937cf640169300b4825124a9d92014-07-01T00:00:00Zhttp://www.dovepress.com/linking-obesity-with-type-2-diabetes-the-role-of-t-bet-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007 Jibran A Wali,1,2 Helen E Thomas,1,2 Andrew PR Sutherland1 1Immunology and Diabetes Unit, St Vincent's Institute, 2Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia Abstract: Obesity is a major predisposing factor for the development of type 2 diabetes (T2D) and is an escalating public health issue around the world. The transition from obesity to T2D is preceded by the induction of a state of insulin resistance, which occurs in response to genetic factors and environmental influences, such as diet. Recent advances have implicated inflammatory immune cells and cytokines as critical pathogenic mediators of insulin resistance and T2D. In particular proinflammatory T helper (Th)1 cells and M1 macrophages are recruited to adipose tissue in response to high fat diet and directly promote the development of insulin resistance. The function of these two cell types is linked by the actions of the cytokine interferon (IFN)γ and one of its major transcriptional regulators T-bet. Recent studies in animal models of T2D demonstrate that T-bet is critical for the development of insulin resistance in response to high fat diet as T-bet-deficient animals are protected from the development of insulin resistance. These data indicate that T-bet and type 1 immunity may constitute novel sites of therapeutic intervention for the treatment of insulin resistance and T2D, in obese human patients. Keywords: type 2 diabetes, obesity, insulin resistance, immune system, T-bet, Th1, IFNγWali JAThomas HESutherlAPRDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2014, Iss default, Pp 331-340 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Wali JA Thomas HE Sutherl APR Linking obesity with type 2 diabetes: the role of T-bet
description	Jibran A Wali,1,2 Helen E Thomas,1,2 Andrew PR Sutherland1 1Immunology and Diabetes Unit, St Vincent's Institute, 2Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia Abstract: Obesity is a major predisposing factor for the development of type 2 diabetes (T2D) and is an escalating public health issue around the world. The transition from obesity to T2D is preceded by the induction of a state of insulin resistance, which occurs in response to genetic factors and environmental influences, such as diet. Recent advances have implicated inflammatory immune cells and cytokines as critical pathogenic mediators of insulin resistance and T2D. In particular proinflammatory T helper (Th)1 cells and M1 macrophages are recruited to adipose tissue in response to high fat diet and directly promote the development of insulin resistance. The function of these two cell types is linked by the actions of the cytokine interferon (IFN)γ and one of its major transcriptional regulators T-bet. Recent studies in animal models of T2D demonstrate that T-bet is critical for the development of insulin resistance in response to high fat diet as T-bet-deficient animals are protected from the development of insulin resistance. These data indicate that T-bet and type 1 immunity may constitute novel sites of therapeutic intervention for the treatment of insulin resistance and T2D, in obese human patients. Keywords: type 2 diabetes, obesity, insulin resistance, immune system, T-bet, Th1, IFNγ
format	article
author	Wali JA Thomas HE Sutherl APR
author_facet	Wali JA Thomas HE Sutherl APR
author_sort	Wali JA
title	Linking obesity with type 2 diabetes: the role of T-bet
title_short	Linking obesity with type 2 diabetes: the role of T-bet
title_full	Linking obesity with type 2 diabetes: the role of T-bet
title_fullStr	Linking obesity with type 2 diabetes: the role of T-bet
title_full_unstemmed	Linking obesity with type 2 diabetes: the role of T-bet
title_sort	linking obesity with type 2 diabetes: the role of t-bet
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/c97d28937cf640169300b4825124a9d9
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Linking obesity with type 2 diabetes: the role of T-bet

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