Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies

Luc&iacute;a Mart&iacute;n-Banderas,1 Josefa &Aacute;lvarez-Fuentes,1 Matilde Dur&aacute;n-Lobato,1 Jos&eacute; Prados,2 Consolaci&oacute;n Melguizo,2 Mercedes Fern&aacute;ndez-Ar&eacute;valo,1 M&ordf; &Aacute;ngeles Hol...

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Autores principales:	Prados J, Melguizo C, Holgado M&Aacute;, Fern&aacute;ndez-Ar&eacute;valo M, Dur&aacute;n-Lobato M, &Aacute;lvarez-Fuentes J, Mart&iacute;n-Banderas L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c981da4f4e864f6fa24e36f5448c44e1
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spelling	oai:doaj.org-article:c981da4f4e864f6fa24e36f5448c44e12021-12-02T06:00:45ZCannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies1176-91141178-2013https://doaj.org/article/c981da4f4e864f6fa24e36f5448c44e12012-11-01T00:00:00Zhttp://www.dovepress.com/cannabinoid-derivate-loaded-plga-nanocarriers-for-oral-administration--a11595https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Luc&iacute;a Mart&iacute;n-Banderas,1 Josefa &Aacute;lvarez-Fuentes,1 Matilde Dur&aacute;n-Lobato,1 Jos&eacute; Prados,2 Consolaci&oacute;n Melguizo,2 Mercedes Fern&aacute;ndez-Ar&eacute;valo,1 M&ordf; &Aacute;ngeles Holgado11Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain; 2Institute of Biopathology and Regenerative Medicine (IBIMER), School of Medicine, University of Granada, Granada, SpainAbstract: CB13 (1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanone)-loaded poly(lactic-co-glycolic acid nanoparticles (NPs) were produced by nanoprecipitation and tested for their in vitro release behavior and in vitro cytotoxicity assays. The effects of several formulation parameters such as polymer type, surfactant concentration, and initial drug amount were studied. NPs had a particle size 90&ndash;300 nm in diameter. Results obtained show that the main influence on particle size was the type of polymer employed during the particle production: the greater the hydrophobicity, the smaller the particle size. In terms of encapsulation efficiency (%), high values were achieved (~68%&ndash;90%) for all formulations prepared due to the poor solubility of CB13 in the external aqueous phase. Moreover, an inverse relationship between release rate and NP size was found. On the other hand, low molecular weight and low lactide content resulted in a less hydrophobic polymer with increased rates of water absorption, hydrolysis, and erosion. NPs showed no cytotoxicity and may be considered to be appropriate for drug-delivery purposes.Keywords: neuropathic pain, CB13, nanoprecipitationPrados JMelguizo CHolgado M&Aacute;Fern&aacute;ndez-Ar&eacute;valo MDur&aacute;n-Lobato M&Aacute;lvarez-Fuentes JMart&iacute;n-Banderas LDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5793-5806 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Prados J Melguizo C Holgado M&Aacute; Fern&aacute;ndez-Ar&eacute;valo M Dur&aacute;n-Lobato M &Aacute;lvarez-Fuentes J Mart&iacute;n-Banderas L Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies
description	Luc&iacute;a Mart&iacute;n-Banderas,1 Josefa &Aacute;lvarez-Fuentes,1 Matilde Dur&aacute;n-Lobato,1 Jos&eacute; Prados,2 Consolaci&oacute;n Melguizo,2 Mercedes Fern&aacute;ndez-Ar&eacute;valo,1 M&ordf; &Aacute;ngeles Holgado11Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain; 2Institute of Biopathology and Regenerative Medicine (IBIMER), School of Medicine, University of Granada, Granada, SpainAbstract: CB13 (1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanone)-loaded poly(lactic-co-glycolic acid nanoparticles (NPs) were produced by nanoprecipitation and tested for their in vitro release behavior and in vitro cytotoxicity assays. The effects of several formulation parameters such as polymer type, surfactant concentration, and initial drug amount were studied. NPs had a particle size 90&ndash;300 nm in diameter. Results obtained show that the main influence on particle size was the type of polymer employed during the particle production: the greater the hydrophobicity, the smaller the particle size. In terms of encapsulation efficiency (%), high values were achieved (~68%&ndash;90%) for all formulations prepared due to the poor solubility of CB13 in the external aqueous phase. Moreover, an inverse relationship between release rate and NP size was found. On the other hand, low molecular weight and low lactide content resulted in a less hydrophobic polymer with increased rates of water absorption, hydrolysis, and erosion. NPs showed no cytotoxicity and may be considered to be appropriate for drug-delivery purposes.Keywords: neuropathic pain, CB13, nanoprecipitation
format	article
author	Prados J Melguizo C Holgado M&Aacute; Fern&aacute;ndez-Ar&eacute;valo M Dur&aacute;n-Lobato M &Aacute;lvarez-Fuentes J Mart&iacute;n-Banderas L
author_facet	Prados J Melguizo C Holgado M&Aacute; Fern&aacute;ndez-Ar&eacute;valo M Dur&aacute;n-Lobato M &Aacute;lvarez-Fuentes J Mart&iacute;n-Banderas L
author_sort	Prados J
title	Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies
title_short	Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies
title_full	Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies
title_fullStr	Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies
title_full_unstemmed	Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies
title_sort	cannabinoid derivate-loaded plga nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/c981da4f4e864f6fa24e36f5448c44e1
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Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies

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