Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
Many genetic variants identified in genome-wide association studies are associated with gene expression. Here, Porcu et al. propose a transcriptome-wide summary statistics-based Mendelian randomization approach (TWMR) that, applied to 43 human traits, uncovers hundreds of previously unreported gene–...
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2019
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oai:doaj.org-article:c983ae75f0ae4e55be76e76f70f6b91a2021-12-02T15:35:59ZMendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits10.1038/s41467-019-10936-02041-1723https://doaj.org/article/c983ae75f0ae4e55be76e76f70f6b91a2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10936-0https://doaj.org/toc/2041-1723Many genetic variants identified in genome-wide association studies are associated with gene expression. Here, Porcu et al. propose a transcriptome-wide summary statistics-based Mendelian randomization approach (TWMR) that, applied to 43 human traits, uncovers hundreds of previously unreported gene–trait associations.Eleonora PorcuSina RüegerKaido LepikeQTLGen ConsortiumBIOS ConsortiumFederico A. SantoniAlexandre ReymondZoltán KutalikNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
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Science Q Eleonora Porcu Sina Rüeger Kaido Lepik eQTLGen Consortium BIOS Consortium Federico A. Santoni Alexandre Reymond Zoltán Kutalik Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits |
description |
Many genetic variants identified in genome-wide association studies are associated with gene expression. Here, Porcu et al. propose a transcriptome-wide summary statistics-based Mendelian randomization approach (TWMR) that, applied to 43 human traits, uncovers hundreds of previously unreported gene–trait associations. |
format |
article |
author |
Eleonora Porcu Sina Rüeger Kaido Lepik eQTLGen Consortium BIOS Consortium Federico A. Santoni Alexandre Reymond Zoltán Kutalik |
author_facet |
Eleonora Porcu Sina Rüeger Kaido Lepik eQTLGen Consortium BIOS Consortium Federico A. Santoni Alexandre Reymond Zoltán Kutalik |
author_sort |
Eleonora Porcu |
title |
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits |
title_short |
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits |
title_full |
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits |
title_fullStr |
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits |
title_full_unstemmed |
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits |
title_sort |
mendelian randomization integrating gwas and eqtl data reveals genetic determinants of complex and clinical traits |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/c983ae75f0ae4e55be76e76f70f6b91a |
work_keys_str_mv |
AT eleonoraporcu mendelianrandomizationintegratinggwasandeqtldatarevealsgeneticdeterminantsofcomplexandclinicaltraits AT sinarueger mendelianrandomizationintegratinggwasandeqtldatarevealsgeneticdeterminantsofcomplexandclinicaltraits AT kaidolepik mendelianrandomizationintegratinggwasandeqtldatarevealsgeneticdeterminantsofcomplexandclinicaltraits AT eqtlgenconsortium mendelianrandomizationintegratinggwasandeqtldatarevealsgeneticdeterminantsofcomplexandclinicaltraits AT biosconsortium mendelianrandomizationintegratinggwasandeqtldatarevealsgeneticdeterminantsofcomplexandclinicaltraits AT federicoasantoni mendelianrandomizationintegratinggwasandeqtldatarevealsgeneticdeterminantsofcomplexandclinicaltraits AT alexandrereymond mendelianrandomizationintegratinggwasandeqtldatarevealsgeneticdeterminantsofcomplexandclinicaltraits AT zoltankutalik mendelianrandomizationintegratinggwasandeqtldatarevealsgeneticdeterminantsofcomplexandclinicaltraits |
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1718386380763037696 |