Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth

Abstract The musculoskeletal system provides the body with correct posture, support, stability, and mobility. It is composed of the bones, muscles, cartilage, tendons, ligaments, joints, and other connective tissues. Without effective countermeasures, prolonged spaceflight under microgravity results...

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Autores principales:	Satoshi Furukawa, Masahiro Chatani, Atsushi Higashitani, Akira Higashibata, Fuminori Kawano, Takeshi Nikawa, Takuro Numaga-Tomita, Toshihiko Ogura, Fuminori Sato, Atsuko Sehara-Fujisawa, Masahiro Shinohara, Toru Shimazu, Satoru Takahashi, Haruko Watanabe-Takano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/c9842190ac0643259e0945e92529a6dc
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spelling	oai:doaj.org-article:c9842190ac0643259e0945e92529a6dc2021-12-02T16:53:08ZFindings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth10.1038/s41526-021-00145-92373-8065https://doaj.org/article/c9842190ac0643259e0945e92529a6dc2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41526-021-00145-9https://doaj.org/toc/2373-8065Abstract The musculoskeletal system provides the body with correct posture, support, stability, and mobility. It is composed of the bones, muscles, cartilage, tendons, ligaments, joints, and other connective tissues. Without effective countermeasures, prolonged spaceflight under microgravity results in marked muscle and bone atrophy. The molecular and physiological mechanisms of this atrophy under unloaded conditions are gradually being revealed through spaceflight experiments conducted by the Japan Aerospace Exploration Agency using a variety of model organisms, including both aquatic and terrestrial animals, and terrestrial experiments conducted under the Living in Space project of the Japan Ministry of Education, Culture, Sports, Science, and Technology. Increasing our knowledge in this field will lead not only to an understanding of how to prevent muscle and bone atrophy in humans undergoing long-term space voyages but also to an understanding of countermeasures against age-related locomotive syndrome in the elderly.Satoshi FurukawaMasahiro ChataniAtsushi HigashitaniAkira HigashibataFuminori KawanoTakeshi NikawaTakuro Numaga-TomitaToshihiko OguraFuminori SatoAtsuko Sehara-FujisawaMasahiro ShinoharaToru ShimazuSatoru TakahashiHaruko Watanabe-TakanoNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Satoshi Furukawa Masahiro Chatani Atsushi Higashitani Akira Higashibata Fuminori Kawano Takeshi Nikawa Takuro Numaga-Tomita Toshihiko Ogura Fuminori Sato Atsuko Sehara-Fujisawa Masahiro Shinohara Toru Shimazu Satoru Takahashi Haruko Watanabe-Takano Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth
description	Abstract The musculoskeletal system provides the body with correct posture, support, stability, and mobility. It is composed of the bones, muscles, cartilage, tendons, ligaments, joints, and other connective tissues. Without effective countermeasures, prolonged spaceflight under microgravity results in marked muscle and bone atrophy. The molecular and physiological mechanisms of this atrophy under unloaded conditions are gradually being revealed through spaceflight experiments conducted by the Japan Aerospace Exploration Agency using a variety of model organisms, including both aquatic and terrestrial animals, and terrestrial experiments conducted under the Living in Space project of the Japan Ministry of Education, Culture, Sports, Science, and Technology. Increasing our knowledge in this field will lead not only to an understanding of how to prevent muscle and bone atrophy in humans undergoing long-term space voyages but also to an understanding of countermeasures against age-related locomotive syndrome in the elderly.
format	article
author	Satoshi Furukawa Masahiro Chatani Atsushi Higashitani Akira Higashibata Fuminori Kawano Takeshi Nikawa Takuro Numaga-Tomita Toshihiko Ogura Fuminori Sato Atsuko Sehara-Fujisawa Masahiro Shinohara Toru Shimazu Satoru Takahashi Haruko Watanabe-Takano
author_facet	Satoshi Furukawa Masahiro Chatani Atsushi Higashitani Akira Higashibata Fuminori Kawano Takeshi Nikawa Takuro Numaga-Tomita Toshihiko Ogura Fuminori Sato Atsuko Sehara-Fujisawa Masahiro Shinohara Toru Shimazu Satoru Takahashi Haruko Watanabe-Takano
author_sort	Satoshi Furukawa
title	Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth
title_short	Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth
title_full	Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth
title_fullStr	Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth
title_full_unstemmed	Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth
title_sort	findings from recent studies by the japan aerospace exploration agency examining musculoskeletal atrophy in space and on earth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9842190ac0643259e0945e92529a6dc
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Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth

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