Correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma.

<h4>Background</h4>Oropharyngeal cancer is an important public health problem. The aim of our study was to correlatep16 immunohistochemistry in oropharynx squamous cell carcinomas(OPSCC) with clinical and epidemiological features.<h4>Material and methods</h4>We conducted acro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chrystiano de C Ferreira, Rozany Dufloth, Ana C de Carvalho, Rui M Reis, Iara Santana, Raiany S Carvalho, Ricardo R Gama
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c984a589b5b74764b267a054be829501
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c984a589b5b74764b267a054be829501
record_format	dspace
spelling	oai:doaj.org-article:c984a589b5b74764b267a054be8295012021-12-02T20:10:27ZCorrelation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma.1932-620310.1371/journal.pone.0253418https://doaj.org/article/c984a589b5b74764b267a054be8295012021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253418https://doaj.org/toc/1932-6203<h4>Background</h4>Oropharyngeal cancer is an important public health problem. The aim of our study was to correlatep16 immunohistochemistry in oropharynx squamous cell carcinomas(OPSCC) with clinical and epidemiological features.<h4>Material and methods</h4>We conducted across-sectional study on patients with OPSCC treated at a single institution from 2014 to 2019. Epidemiological and clinical-pathological data were collected from medical records and a questionnaire was applied to determine alcohol consumption, smoking, and sexual behavior. The HPV status was determined by p16 immunohistochemistry.<h4>Results</h4>A total of 252 patients participated in the study, of these 221 (87.7%) were male. There were 81 (32.14%) p16 positive cases and 171 (67.85%) p16 negative cases. The p16positive group was significantly associated with younger patients (50-59 years), higher education level, lower clinical stage and patients who never drank or smoked. Through univariate logistic regression, we observed that female sex (OR, 3.47; 95% CI, 1.60-7.51) and higher education level (OR, 9.39; 95% CI, 2, 81-31,38) were significantly more likely to be p16 positive. Early clinical stage (AJCC8ed) was more associated with p16 positivity both in univariate (OR, 0.14; 95% CI, 0.07-0.26, p<0.001) and multivariate analysis (OR, 0.18; 95% CI, 0.06-0.49, p = 0.001).<h4>Conclusion</h4>This study showed that drinkers and current smokers were less likely to be p16+. Female sex, higher education level and younger age at diagnosis were associated with a higher probability of being p16+. Additionally, there was a higher proportion of patients with early clinical stage (I or II) in the p16 positive group when compared to the p16 negative group.Chrystiano de C FerreiraRozany DuflothAna C de CarvalhoRui M ReisIara SantanaRaiany S CarvalhoRicardo R GamaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253418 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chrystiano de C Ferreira Rozany Dufloth Ana C de Carvalho Rui M Reis Iara Santana Raiany S Carvalho Ricardo R Gama Correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma.
description	<h4>Background</h4>Oropharyngeal cancer is an important public health problem. The aim of our study was to correlatep16 immunohistochemistry in oropharynx squamous cell carcinomas(OPSCC) with clinical and epidemiological features.<h4>Material and methods</h4>We conducted across-sectional study on patients with OPSCC treated at a single institution from 2014 to 2019. Epidemiological and clinical-pathological data were collected from medical records and a questionnaire was applied to determine alcohol consumption, smoking, and sexual behavior. The HPV status was determined by p16 immunohistochemistry.<h4>Results</h4>A total of 252 patients participated in the study, of these 221 (87.7%) were male. There were 81 (32.14%) p16 positive cases and 171 (67.85%) p16 negative cases. The p16positive group was significantly associated with younger patients (50-59 years), higher education level, lower clinical stage and patients who never drank or smoked. Through univariate logistic regression, we observed that female sex (OR, 3.47; 95% CI, 1.60-7.51) and higher education level (OR, 9.39; 95% CI, 2, 81-31,38) were significantly more likely to be p16 positive. Early clinical stage (AJCC8ed) was more associated with p16 positivity both in univariate (OR, 0.14; 95% CI, 0.07-0.26, p<0.001) and multivariate analysis (OR, 0.18; 95% CI, 0.06-0.49, p = 0.001).<h4>Conclusion</h4>This study showed that drinkers and current smokers were less likely to be p16+. Female sex, higher education level and younger age at diagnosis were associated with a higher probability of being p16+. Additionally, there was a higher proportion of patients with early clinical stage (I or II) in the p16 positive group when compared to the p16 negative group.
format	article
author	Chrystiano de C Ferreira Rozany Dufloth Ana C de Carvalho Rui M Reis Iara Santana Raiany S Carvalho Ricardo R Gama
author_facet	Chrystiano de C Ferreira Rozany Dufloth Ana C de Carvalho Rui M Reis Iara Santana Raiany S Carvalho Ricardo R Gama
author_sort	Chrystiano de C Ferreira
title	Correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma.
title_short	Correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma.
title_full	Correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma.
title_fullStr	Correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma.
title_full_unstemmed	Correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma.
title_sort	correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c984a589b5b74764b267a054be829501
work_keys_str_mv	AT chrystianodecferreira correlationofp16immunohistochemistrywithclinicalandepidemiologicalfeaturesinoropharyngealsquamouscellcarcinoma AT rozanydufloth correlationofp16immunohistochemistrywithclinicalandepidemiologicalfeaturesinoropharyngealsquamouscellcarcinoma AT anacdecarvalho correlationofp16immunohistochemistrywithclinicalandepidemiologicalfeaturesinoropharyngealsquamouscellcarcinoma AT ruimreis correlationofp16immunohistochemistrywithclinicalandepidemiologicalfeaturesinoropharyngealsquamouscellcarcinoma AT iarasantana correlationofp16immunohistochemistrywithclinicalandepidemiologicalfeaturesinoropharyngealsquamouscellcarcinoma AT raianyscarvalho correlationofp16immunohistochemistrywithclinicalandepidemiologicalfeaturesinoropharyngealsquamouscellcarcinoma AT ricardorgama correlationofp16immunohistochemistrywithclinicalandepidemiologicalfeaturesinoropharyngealsquamouscellcarcinoma
_version_	1718375024799252480

Correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma.

Ejemplares similares