Symptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections—Upper Silesia pilot study

Abstract In the DECODE project, data were collected from 3,114 surveys filled by symptomatic patients RT-qPCR tested for SARS-CoV-2 in a single university centre in March-September 2020. The population demonstrated balanced sex and age with 759 SARS-CoV-2( +) patients. The most discriminative sympto...

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Autores principales:	Justyna Mika, Joanna Tobiasz, Joanna Zyla, Anna Papiez, Małgorzata Bach, Aleksandra Werner, Michał Kozielski, Mateusz Kania, Aleksandra Gruca, Damian Piotrowski, Barbara Sobala-Szczygieł, Bożena Włostowska, Paweł Foszner, Marek Sikora, Joanna Polanska, Jerzy Jaroszewicz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9873397e3a945eeae1a622bdf8cc0c7
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spelling	oai:doaj.org-article:c9873397e3a945eeae1a622bdf8cc0c72021-12-02T14:34:03ZSymptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections—Upper Silesia pilot study10.1038/s41598-021-93046-62045-2322https://doaj.org/article/c9873397e3a945eeae1a622bdf8cc0c72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93046-6https://doaj.org/toc/2045-2322Abstract In the DECODE project, data were collected from 3,114 surveys filled by symptomatic patients RT-qPCR tested for SARS-CoV-2 in a single university centre in March-September 2020. The population demonstrated balanced sex and age with 759 SARS-CoV-2( +) patients. The most discriminative symptoms in SARS-CoV-2( +) patients at early infection stage were loss of taste/smell (OR = 3.33, p < 0.0001), body temperature above 38℃ (OR = 1.67, p < 0.0001), muscle aches (OR = 1.30, p = 0.0242), headache (OR = 1.27, p = 0.0405), cough (OR = 1.26, p = 0.0477). Dyspnea was more often reported among SARS-CoV-2(-) (OR = 0.55, p < 0.0001). Cough and dyspnea were 3.5 times more frequent among SARS-CoV-2(-) (OR = 0.28, p < 0.0001). Co-occurrence of cough, muscle aches, headache, loss of taste/smell (OR = 4.72, p = 0.0015) appeared significant, although co-occurrence of two symptoms only, cough and loss of smell or taste, means OR = 2.49 (p < 0.0001). Temperature > 38℃ with cough was most frequent in men (20%), while loss of taste/smell with cough in women (17%). For younger people, taste/smell impairment is sufficient to characterise infection, whereas in older patients co-occurrence of fever and cough is necessary. The presented study objectifies the single symptoms and interactions significance in COVID-19 diagnoses and demonstrates diverse symptomatology in patient groups.Justyna MikaJoanna TobiaszJoanna ZylaAnna PapiezMałgorzata BachAleksandra WernerMichał KozielskiMateusz KaniaAleksandra GrucaDamian PiotrowskiBarbara Sobala-SzczygiełBożena WłostowskaPaweł FosznerMarek SikoraJoanna PolanskaJerzy JaroszewiczNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Justyna Mika Joanna Tobiasz Joanna Zyla Anna Papiez Małgorzata Bach Aleksandra Werner Michał Kozielski Mateusz Kania Aleksandra Gruca Damian Piotrowski Barbara Sobala-Szczygieł Bożena Włostowska Paweł Foszner Marek Sikora Joanna Polanska Jerzy Jaroszewicz Symptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections—Upper Silesia pilot study
description	Abstract In the DECODE project, data were collected from 3,114 surveys filled by symptomatic patients RT-qPCR tested for SARS-CoV-2 in a single university centre in March-September 2020. The population demonstrated balanced sex and age with 759 SARS-CoV-2( +) patients. The most discriminative symptoms in SARS-CoV-2( +) patients at early infection stage were loss of taste/smell (OR = 3.33, p < 0.0001), body temperature above 38℃ (OR = 1.67, p < 0.0001), muscle aches (OR = 1.30, p = 0.0242), headache (OR = 1.27, p = 0.0405), cough (OR = 1.26, p = 0.0477). Dyspnea was more often reported among SARS-CoV-2(-) (OR = 0.55, p < 0.0001). Cough and dyspnea were 3.5 times more frequent among SARS-CoV-2(-) (OR = 0.28, p < 0.0001). Co-occurrence of cough, muscle aches, headache, loss of taste/smell (OR = 4.72, p = 0.0015) appeared significant, although co-occurrence of two symptoms only, cough and loss of smell or taste, means OR = 2.49 (p < 0.0001). Temperature > 38℃ with cough was most frequent in men (20%), while loss of taste/smell with cough in women (17%). For younger people, taste/smell impairment is sufficient to characterise infection, whereas in older patients co-occurrence of fever and cough is necessary. The presented study objectifies the single symptoms and interactions significance in COVID-19 diagnoses and demonstrates diverse symptomatology in patient groups.
format	article
author	Justyna Mika Joanna Tobiasz Joanna Zyla Anna Papiez Małgorzata Bach Aleksandra Werner Michał Kozielski Mateusz Kania Aleksandra Gruca Damian Piotrowski Barbara Sobala-Szczygieł Bożena Włostowska Paweł Foszner Marek Sikora Joanna Polanska Jerzy Jaroszewicz
author_facet	Justyna Mika Joanna Tobiasz Joanna Zyla Anna Papiez Małgorzata Bach Aleksandra Werner Michał Kozielski Mateusz Kania Aleksandra Gruca Damian Piotrowski Barbara Sobala-Szczygieł Bożena Włostowska Paweł Foszner Marek Sikora Joanna Polanska Jerzy Jaroszewicz
author_sort	Justyna Mika
title	Symptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections—Upper Silesia pilot study
title_short	Symptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections—Upper Silesia pilot study
title_full	Symptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections—Upper Silesia pilot study
title_fullStr	Symptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections—Upper Silesia pilot study
title_full_unstemmed	Symptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections—Upper Silesia pilot study
title_sort	symptom-based early-stage differentiation between sars-cov-2 versus other respiratory tract infections—upper silesia pilot study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9873397e3a945eeae1a622bdf8cc0c7
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Symptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections—Upper Silesia pilot study

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