Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer

Only a subset of triple negative breast cancer patients respond to immunotherapy. Here, the authors analysed spatial immune contextures, which can be captured by a gene classifier, in relation to genomic alterations, mechanisms of T cell evasion and response to anti-PD1 treatment.

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Autores principales:	Dora Hammerl, John W. M. Martens, Mieke Timmermans, Marcel Smid, Anita M. Trapman-Jansen, Renée Foekens, Olga I. Isaeva, Leonie Voorwerk, Hayri E. Balcioglu, Rebecca Wijers, Iris Nederlof, Roberto Salgado, Hugo Horlings, Marleen Kok, Reno Debets
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c987387dc5c94a1b93ac3cb4c523d2fd
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spelling	oai:doaj.org-article:c987387dc5c94a1b93ac3cb4c523d2fd2021-12-02T17:37:41ZSpatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer10.1038/s41467-021-25962-02041-1723https://doaj.org/article/c987387dc5c94a1b93ac3cb4c523d2fd2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25962-0https://doaj.org/toc/2041-1723Only a subset of triple negative breast cancer patients respond to immunotherapy. Here, the authors analysed spatial immune contextures, which can be captured by a gene classifier, in relation to genomic alterations, mechanisms of T cell evasion and response to anti-PD1 treatment.Dora HammerlJohn W. M. MartensMieke TimmermansMarcel SmidAnita M. Trapman-JansenRenée FoekensOlga I. IsaevaLeonie VoorwerkHayri E. BalciogluRebecca WijersIris NederlofRoberto SalgadoHugo HorlingsMarleen KokReno DebetsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dora Hammerl John W. M. Martens Mieke Timmermans Marcel Smid Anita M. Trapman-Jansen Renée Foekens Olga I. Isaeva Leonie Voorwerk Hayri E. Balcioglu Rebecca Wijers Iris Nederlof Roberto Salgado Hugo Horlings Marleen Kok Reno Debets Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer
description	Only a subset of triple negative breast cancer patients respond to immunotherapy. Here, the authors analysed spatial immune contextures, which can be captured by a gene classifier, in relation to genomic alterations, mechanisms of T cell evasion and response to anti-PD1 treatment.
format	article
author	Dora Hammerl John W. M. Martens Mieke Timmermans Marcel Smid Anita M. Trapman-Jansen Renée Foekens Olga I. Isaeva Leonie Voorwerk Hayri E. Balcioglu Rebecca Wijers Iris Nederlof Roberto Salgado Hugo Horlings Marleen Kok Reno Debets
author_facet	Dora Hammerl John W. M. Martens Mieke Timmermans Marcel Smid Anita M. Trapman-Jansen Renée Foekens Olga I. Isaeva Leonie Voorwerk Hayri E. Balcioglu Rebecca Wijers Iris Nederlof Roberto Salgado Hugo Horlings Marleen Kok Reno Debets
author_sort	Dora Hammerl
title	Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer
title_short	Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer
title_full	Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer
title_fullStr	Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer
title_full_unstemmed	Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer
title_sort	spatial immunophenotypes predict response to anti-pd1 treatment and capture distinct paths of t cell evasion in triple negative breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c987387dc5c94a1b93ac3cb4c523d2fd
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Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer

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