Induction of immunosuppressive functions and NF-κB by FLIP in monocytes

Signaling and transcriptional regulation of MDSC activity remains largely undefined. Here the authors show that monocytic MDSC immunosuppression is triggered by c-FLIP and requires NFκB, implicate this axis in cancer prognosis and response to therapy, and employ ectopic FLIP to treat immunopathology...

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Autores principales:	Alessandra Fiore, Stefano Ugel, Francesco De Sanctis, Sara Sandri, Giulio Fracasso, Rosalinda Trovato, Silvia Sartoris, Samantha Solito, Susanna Mandruzzato, Fulvia Vascotto, Keli L. Hippen, Giada Mondanelli, Ursula Grohmann, Geny Piro, Carmine Carbone, Davide Melisi, Rita T. Lawlor, Aldo Scarpa, Alessia Lamolinara, Manuela Iezzi, Matteo Fassan, Silvio Bicciato, Bruce R. Blazar, Ugur Sahin, Peter J. Murray, Vincenzo Bronte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c988a8bcde8c4a15aa07366b491c041d
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spelling	oai:doaj.org-article:c988a8bcde8c4a15aa07366b491c041d2021-12-02T14:38:52ZInduction of immunosuppressive functions and NF-κB by FLIP in monocytes10.1038/s41467-018-07654-42041-1723https://doaj.org/article/c988a8bcde8c4a15aa07366b491c041d2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07654-4https://doaj.org/toc/2041-1723Signaling and transcriptional regulation of MDSC activity remains largely undefined. Here the authors show that monocytic MDSC immunosuppression is triggered by c-FLIP and requires NFκB, implicate this axis in cancer prognosis and response to therapy, and employ ectopic FLIP to treat immunopathology.Alessandra FioreStefano UgelFrancesco De SanctisSara SandriGiulio FracassoRosalinda TrovatoSilvia SartorisSamantha SolitoSusanna MandruzzatoFulvia VascottoKeli L. HippenGiada MondanelliUrsula GrohmannGeny PiroCarmine CarboneDavide MelisiRita T. LawlorAldo ScarpaAlessia LamolinaraManuela IezziMatteo FassanSilvio BicciatoBruce R. BlazarUgur SahinPeter J. MurrayVincenzo BronteNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandra Fiore Stefano Ugel Francesco De Sanctis Sara Sandri Giulio Fracasso Rosalinda Trovato Silvia Sartoris Samantha Solito Susanna Mandruzzato Fulvia Vascotto Keli L. Hippen Giada Mondanelli Ursula Grohmann Geny Piro Carmine Carbone Davide Melisi Rita T. Lawlor Aldo Scarpa Alessia Lamolinara Manuela Iezzi Matteo Fassan Silvio Bicciato Bruce R. Blazar Ugur Sahin Peter J. Murray Vincenzo Bronte Induction of immunosuppressive functions and NF-κB by FLIP in monocytes
description	Signaling and transcriptional regulation of MDSC activity remains largely undefined. Here the authors show that monocytic MDSC immunosuppression is triggered by c-FLIP and requires NFκB, implicate this axis in cancer prognosis and response to therapy, and employ ectopic FLIP to treat immunopathology.
format	article
author	Alessandra Fiore Stefano Ugel Francesco De Sanctis Sara Sandri Giulio Fracasso Rosalinda Trovato Silvia Sartoris Samantha Solito Susanna Mandruzzato Fulvia Vascotto Keli L. Hippen Giada Mondanelli Ursula Grohmann Geny Piro Carmine Carbone Davide Melisi Rita T. Lawlor Aldo Scarpa Alessia Lamolinara Manuela Iezzi Matteo Fassan Silvio Bicciato Bruce R. Blazar Ugur Sahin Peter J. Murray Vincenzo Bronte
author_facet	Alessandra Fiore Stefano Ugel Francesco De Sanctis Sara Sandri Giulio Fracasso Rosalinda Trovato Silvia Sartoris Samantha Solito Susanna Mandruzzato Fulvia Vascotto Keli L. Hippen Giada Mondanelli Ursula Grohmann Geny Piro Carmine Carbone Davide Melisi Rita T. Lawlor Aldo Scarpa Alessia Lamolinara Manuela Iezzi Matteo Fassan Silvio Bicciato Bruce R. Blazar Ugur Sahin Peter J. Murray Vincenzo Bronte
author_sort	Alessandra Fiore
title	Induction of immunosuppressive functions and NF-κB by FLIP in monocytes
title_short	Induction of immunosuppressive functions and NF-κB by FLIP in monocytes
title_full	Induction of immunosuppressive functions and NF-κB by FLIP in monocytes
title_fullStr	Induction of immunosuppressive functions and NF-κB by FLIP in monocytes
title_full_unstemmed	Induction of immunosuppressive functions and NF-κB by FLIP in monocytes
title_sort	induction of immunosuppressive functions and nf-κb by flip in monocytes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c988a8bcde8c4a15aa07366b491c041d
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Induction of immunosuppressive functions and NF-κB by FLIP in monocytes

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