Short Communication: Obesity Intervention Resulting in Significant Changes in the Human Gut Viral Composition

Obesity is a health problem of global concern that negatively impacts quality of life. Various studies have implicated obesity in the disruption of the normal microbiome composition. The virome consists of a collection of all the viruses that inhabit a particular niche. However, the study of such vi...

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Autores principales:	Diego Sandoval-Vargas, Nataly D. Concha-Rubio, Paola Navarrete, Matías Castro, Daniel A. Medina
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	obesity human gut microbiome human gut virome viral changes Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c988d924fc6140d797e79450c84d299f
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spelling	oai:doaj.org-article:c988d924fc6140d797e79450c84d299f2021-11-11T15:07:11ZShort Communication: Obesity Intervention Resulting in Significant Changes in the Human Gut Viral Composition10.3390/app1121100392076-3417https://doaj.org/article/c988d924fc6140d797e79450c84d299f2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/10039https://doaj.org/toc/2076-3417Obesity is a health problem of global concern that negatively impacts quality of life. Various studies have implicated obesity in the disruption of the normal microbiome composition. The virome consists of a collection of all the viruses that inhabit a particular niche. However, the study of such viruses that compose the human gut microbiome in the context of obesity has been paid little attention. One interesting aspect of virome study is the description of phages that can specifically interact with the bacterial component of the microbiota and modulate the microbiome’s dynamics. Previous work showed that the microbiota composition changes after obesity treatment and that these changes are country specific. In this work, we perform a quick gut viral composition of the gut microbiota of patients from Denmark, Italy, and Chile before and after obesity intervention using metagenomic sequences previously published and bioinformatics tools. Our results showed that obesity treatment results in significant changes in the human gut viral composition. These results conclude that the virome composition changes after obesity intervention by suggesting that changes can be related to the microbiota rearrangements reported in other works and may be involved in microbial dynamics after treatment.Diego Sandoval-VargasNataly D. Concha-RubioPaola NavarreteMatías CastroDaniel A. MedinaMDPI AGarticleobesityhuman gut microbiomehuman gut viromeviral changesTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10039, p 10039 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity human gut microbiome human gut virome viral changes Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	obesity human gut microbiome human gut virome viral changes Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Diego Sandoval-Vargas Nataly D. Concha-Rubio Paola Navarrete Matías Castro Daniel A. Medina Short Communication: Obesity Intervention Resulting in Significant Changes in the Human Gut Viral Composition
description	Obesity is a health problem of global concern that negatively impacts quality of life. Various studies have implicated obesity in the disruption of the normal microbiome composition. The virome consists of a collection of all the viruses that inhabit a particular niche. However, the study of such viruses that compose the human gut microbiome in the context of obesity has been paid little attention. One interesting aspect of virome study is the description of phages that can specifically interact with the bacterial component of the microbiota and modulate the microbiome’s dynamics. Previous work showed that the microbiota composition changes after obesity treatment and that these changes are country specific. In this work, we perform a quick gut viral composition of the gut microbiota of patients from Denmark, Italy, and Chile before and after obesity intervention using metagenomic sequences previously published and bioinformatics tools. Our results showed that obesity treatment results in significant changes in the human gut viral composition. These results conclude that the virome composition changes after obesity intervention by suggesting that changes can be related to the microbiota rearrangements reported in other works and may be involved in microbial dynamics after treatment.
format	article
author	Diego Sandoval-Vargas Nataly D. Concha-Rubio Paola Navarrete Matías Castro Daniel A. Medina
author_facet	Diego Sandoval-Vargas Nataly D. Concha-Rubio Paola Navarrete Matías Castro Daniel A. Medina
author_sort	Diego Sandoval-Vargas
title	Short Communication: Obesity Intervention Resulting in Significant Changes in the Human Gut Viral Composition
title_short	Short Communication: Obesity Intervention Resulting in Significant Changes in the Human Gut Viral Composition
title_full	Short Communication: Obesity Intervention Resulting in Significant Changes in the Human Gut Viral Composition
title_fullStr	Short Communication: Obesity Intervention Resulting in Significant Changes in the Human Gut Viral Composition
title_full_unstemmed	Short Communication: Obesity Intervention Resulting in Significant Changes in the Human Gut Viral Composition
title_sort	short communication: obesity intervention resulting in significant changes in the human gut viral composition
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c988d924fc6140d797e79450c84d299f
work_keys_str_mv	AT diegosandovalvargas shortcommunicationobesityinterventionresultinginsignificantchangesinthehumangutviralcomposition AT natalydconcharubio shortcommunicationobesityinterventionresultinginsignificantchangesinthehumangutviralcomposition AT paolanavarrete shortcommunicationobesityinterventionresultinginsignificantchangesinthehumangutviralcomposition AT matiascastro shortcommunicationobesityinterventionresultinginsignificantchangesinthehumangutviralcomposition AT danielamedina shortcommunicationobesityinterventionresultinginsignificantchangesinthehumangutviralcomposition
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Short Communication: Obesity Intervention Resulting in Significant Changes in the Human Gut Viral Composition

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