Compatibility between an overnight fasting and random cholesterol tests in Asians

Abstract Recent Western guidelines recommend non-fasting lipid profiles to manage dyslipidaemia. We explored its applicability to an Asian population. We determined the differences between an overnight fasting and non-fasting cholesterol profiles of patients with type-2 diabetes mellitus (T2DM) in S...

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Autores principales:	Ian Kwong Yun Phoon, Yi Ling Eileen Koh, Xiaoxuan Guo, Sankari Usha, Ngiap Chuan Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c98b6a09f21048b29ba7f826b626b50b
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spelling	oai:doaj.org-article:c98b6a09f21048b29ba7f826b626b50b2021-12-02T13:17:49ZCompatibility between an overnight fasting and random cholesterol tests in Asians10.1038/s41598-021-85914-y2045-2322https://doaj.org/article/c98b6a09f21048b29ba7f826b626b50b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85914-yhttps://doaj.org/toc/2045-2322Abstract Recent Western guidelines recommend non-fasting lipid profiles to manage dyslipidaemia. We explored its applicability to an Asian population. We determined the differences between an overnight fasting and non-fasting cholesterol profiles of patients with type-2 diabetes mellitus (T2DM) in Singapore. We studied 470 multi-ethnic Asian adult patients with T2DM and dyslipidaemia from 2 primary care clinics in Singapore. Non-fasting blood specimens were collected within 6 h after their last meal and within 14 days of a fasting specimen. The intraclass correlation coefficient (ICC) was used to compare the intraindividual lipid profiles. An ICC value > 0.75 implies good correlation. The mean age and T2DM duration of the study population were 62.5 years and 9.8 years respectively. Their mean non-fasting period was 2.46 h. The mean differences between non-fasting and fasting total cholesterol (TC), high-density lipoprotein (HDL-C), triglyceride (TG), low-density lipoprotein (LDL-C), and non HDL-C were + 0.04 mmol/l, − 0.001 mmol/l, + 0.48 mmol/l, − 0.15 mmol/l, and − 0.05 mmol/l respectively. The ICC (95% CI) for TC, HDL-C, TG, LDL-C and non-HDL-C were 0.820 (0.788–0.847), 0.873 (0.850–0.893), 0.579 (0.516–0.636), 0.764 (0.723–0.799), and 0.825 (0.794–0.852) respectively. The fasting and non-fasting lipid profiles were similar in our local Asian patients with T2DM taking statin. Their non-fasting lipid profile can be used to assess their cholesterol treatment status.Ian Kwong Yun PhoonYi Ling Eileen KohXiaoxuan GuoSankari UshaNgiap Chuan TanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ian Kwong Yun Phoon Yi Ling Eileen Koh Xiaoxuan Guo Sankari Usha Ngiap Chuan Tan Compatibility between an overnight fasting and random cholesterol tests in Asians
description	Abstract Recent Western guidelines recommend non-fasting lipid profiles to manage dyslipidaemia. We explored its applicability to an Asian population. We determined the differences between an overnight fasting and non-fasting cholesterol profiles of patients with type-2 diabetes mellitus (T2DM) in Singapore. We studied 470 multi-ethnic Asian adult patients with T2DM and dyslipidaemia from 2 primary care clinics in Singapore. Non-fasting blood specimens were collected within 6 h after their last meal and within 14 days of a fasting specimen. The intraclass correlation coefficient (ICC) was used to compare the intraindividual lipid profiles. An ICC value > 0.75 implies good correlation. The mean age and T2DM duration of the study population were 62.5 years and 9.8 years respectively. Their mean non-fasting period was 2.46 h. The mean differences between non-fasting and fasting total cholesterol (TC), high-density lipoprotein (HDL-C), triglyceride (TG), low-density lipoprotein (LDL-C), and non HDL-C were + 0.04 mmol/l, − 0.001 mmol/l, + 0.48 mmol/l, − 0.15 mmol/l, and − 0.05 mmol/l respectively. The ICC (95% CI) for TC, HDL-C, TG, LDL-C and non-HDL-C were 0.820 (0.788–0.847), 0.873 (0.850–0.893), 0.579 (0.516–0.636), 0.764 (0.723–0.799), and 0.825 (0.794–0.852) respectively. The fasting and non-fasting lipid profiles were similar in our local Asian patients with T2DM taking statin. Their non-fasting lipid profile can be used to assess their cholesterol treatment status.
format	article
author	Ian Kwong Yun Phoon Yi Ling Eileen Koh Xiaoxuan Guo Sankari Usha Ngiap Chuan Tan
author_facet	Ian Kwong Yun Phoon Yi Ling Eileen Koh Xiaoxuan Guo Sankari Usha Ngiap Chuan Tan
author_sort	Ian Kwong Yun Phoon
title	Compatibility between an overnight fasting and random cholesterol tests in Asians
title_short	Compatibility between an overnight fasting and random cholesterol tests in Asians
title_full	Compatibility between an overnight fasting and random cholesterol tests in Asians
title_fullStr	Compatibility between an overnight fasting and random cholesterol tests in Asians
title_full_unstemmed	Compatibility between an overnight fasting and random cholesterol tests in Asians
title_sort	compatibility between an overnight fasting and random cholesterol tests in asians
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c98b6a09f21048b29ba7f826b626b50b
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Compatibility between an overnight fasting and random cholesterol tests in Asians

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