Network‐based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions

Abstract Background Online repetitive transcranialmagnetic stimulation (rTMS) has been shown to modulate working memory (WM) performance in a site‐specific manner, with behavioral improvements due to stimulation of the dorsolateral prefrontal cortex (DLPFC), and impairment from stimulation to the la...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lysianne Beynel, Moritz Dannhauer, Hannah Palmer, Susan A. Hilbig, Courtney A. Crowell, Joyce E‐H. Wang, Andrew M. Michael, Eleanor A. Wood, Bruce Luber, Sarah H. Lisanby, Angel V. Peterchev, Roberto Cabeza, Simon W. Davis, Lawrence G. Appelbaum
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	DLPFC parietal cortex repetitive transcranial magnetic stimulation working memory Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c98f85b72ba74c2685bd223596e1dac2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c98f85b72ba74c2685bd223596e1dac2
record_format	dspace
spelling	oai:doaj.org-article:c98f85b72ba74c2685bd223596e1dac22021-11-25T06:06:36ZNetwork‐based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions2162-327910.1002/brb3.2361https://doaj.org/article/c98f85b72ba74c2685bd223596e1dac22021-11-01T00:00:00Zhttps://doi.org/10.1002/brb3.2361https://doaj.org/toc/2162-3279Abstract Background Online repetitive transcranialmagnetic stimulation (rTMS) has been shown to modulate working memory (WM) performance in a site‐specific manner, with behavioral improvements due to stimulation of the dorsolateral prefrontal cortex (DLPFC), and impairment from stimulation to the lateral parietal cortex (LPC). Neurobehavioral studies have demonstrated that subprocesses of WM allowing for the maintenance and manipulation of information in the mind involve unique cortical networks. Despite promising evidence of modulatory effects of rTMS on WM, no studies have yet demonstrated distinct modulatory control of these two subprocesses. The current study therefore sought to explore this possibility through site‐specific stimulation during an online task invoking both skills. Methods Twenty‐nine subjects completed a 4‐day protocol, in which active or sham 5Hz rTMS was applied over the DLPFC and LPC in separate blocks of trials while participants performed tasks that required either maintenance alone, or both maintenance and manipulation (alphabetization) of information. Stimulation targets were defined individually based on fMRI activation and structural network properties. Stimulation amplitude was adjusted using electric field modeling to equate induced current in the target region across participants. Results Despite the use of advanced techniques, no significant differences or interactions between active and sham stimulation were found. Exploratory analyses testing stimulation amplitude, fMRI activation, and modal controllability showed nonsignificant but interesting trends with rTMS effects. Conclusion While this study did not reveal any significant behavioral changes in WM, the results may point to parameters that contribute to positive effects, such as stimulation amplitude and functional activation.Lysianne BeynelMoritz DannhauerHannah PalmerSusan A. HilbigCourtney A. CrowellJoyce E‐H. WangAndrew M. MichaelEleanor A. WoodBruce LuberSarah H. LisanbyAngel V. PeterchevRoberto CabezaSimon W. DavisLawrence G. AppelbaumWileyarticleDLPFCparietal cortexrepetitive transcranial magnetic stimulationworking memoryNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain and Behavior, Vol 11, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DLPFC parietal cortex repetitive transcranial magnetic stimulation working memory Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	DLPFC parietal cortex repetitive transcranial magnetic stimulation working memory Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Lysianne Beynel Moritz Dannhauer Hannah Palmer Susan A. Hilbig Courtney A. Crowell Joyce E‐H. Wang Andrew M. Michael Eleanor A. Wood Bruce Luber Sarah H. Lisanby Angel V. Peterchev Roberto Cabeza Simon W. Davis Lawrence G. Appelbaum Network‐based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions
description	Abstract Background Online repetitive transcranialmagnetic stimulation (rTMS) has been shown to modulate working memory (WM) performance in a site‐specific manner, with behavioral improvements due to stimulation of the dorsolateral prefrontal cortex (DLPFC), and impairment from stimulation to the lateral parietal cortex (LPC). Neurobehavioral studies have demonstrated that subprocesses of WM allowing for the maintenance and manipulation of information in the mind involve unique cortical networks. Despite promising evidence of modulatory effects of rTMS on WM, no studies have yet demonstrated distinct modulatory control of these two subprocesses. The current study therefore sought to explore this possibility through site‐specific stimulation during an online task invoking both skills. Methods Twenty‐nine subjects completed a 4‐day protocol, in which active or sham 5Hz rTMS was applied over the DLPFC and LPC in separate blocks of trials while participants performed tasks that required either maintenance alone, or both maintenance and manipulation (alphabetization) of information. Stimulation targets were defined individually based on fMRI activation and structural network properties. Stimulation amplitude was adjusted using electric field modeling to equate induced current in the target region across participants. Results Despite the use of advanced techniques, no significant differences or interactions between active and sham stimulation were found. Exploratory analyses testing stimulation amplitude, fMRI activation, and modal controllability showed nonsignificant but interesting trends with rTMS effects. Conclusion While this study did not reveal any significant behavioral changes in WM, the results may point to parameters that contribute to positive effects, such as stimulation amplitude and functional activation.
format	article
author	Lysianne Beynel Moritz Dannhauer Hannah Palmer Susan A. Hilbig Courtney A. Crowell Joyce E‐H. Wang Andrew M. Michael Eleanor A. Wood Bruce Luber Sarah H. Lisanby Angel V. Peterchev Roberto Cabeza Simon W. Davis Lawrence G. Appelbaum
author_facet	Lysianne Beynel Moritz Dannhauer Hannah Palmer Susan A. Hilbig Courtney A. Crowell Joyce E‐H. Wang Andrew M. Michael Eleanor A. Wood Bruce Luber Sarah H. Lisanby Angel V. Peterchev Roberto Cabeza Simon W. Davis Lawrence G. Appelbaum
author_sort	Lysianne Beynel
title	Network‐based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions
title_short	Network‐based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions
title_full	Network‐based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions
title_fullStr	Network‐based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions
title_full_unstemmed	Network‐based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions
title_sort	network‐based rtms to modulate working memory: the difficult choice of effective parameters for online interventions
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/c98f85b72ba74c2685bd223596e1dac2
work_keys_str_mv	AT lysiannebeynel networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT moritzdannhauer networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT hannahpalmer networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT susanahilbig networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT courtneyacrowell networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT joyceehwang networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT andrewmmichael networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT eleanorawood networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT bruceluber networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT sarahhlisanby networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT angelvpeterchev networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT robertocabeza networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT simonwdavis networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions AT lawrencegappelbaum networkbasedrtmstomodulateworkingmemorythedifficultchoiceofeffectiveparametersforonlineinterventions
_version_	1718414190471806976

Network‐based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions

Ejemplares similares