Use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies

Barry A SchechterCornea and Cataract Service, Florida Eye Microsurgical Institute, Boynton Beach, FL, USAAbstract: Topical ophthalmic nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat postoperative inflammation and pain following cataract surgery and for treatment and prophyla...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Schechter BA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	bromfenac clinical studies ocular inflammation pain safety Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c99162c1e0de4c70bfd03d76bcb45647
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c99162c1e0de4c70bfd03d76bcb45647
record_format	dspace
spelling	oai:doaj.org-article:c99162c1e0de4c70bfd03d76bcb456472021-12-02T07:05:50ZUse of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies1177-5483https://doaj.org/article/c99162c1e0de4c70bfd03d76bcb456472019-08-01T00:00:00Zhttps://www.dovepress.com/use-of-topical-bromfenac-for-treating-ocular-pain-and-inflammation-bey-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Barry A SchechterCornea and Cataract Service, Florida Eye Microsurgical Institute, Boynton Beach, FL, USAAbstract: Topical ophthalmic nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat postoperative inflammation and pain following cataract surgery and for treatment and prophylaxis of pseudophakic cystoid macular edema (CME). Bromfenac is a brominated NSAID with strong in vitro anti-inflammatory potency. Like other ophthalmic NSAIDs, bromfenac is often used outside of the cataract surgery setting. This paper provides an overview of bromfenac’s preclinical ocular pharmacology and pharmacokinetics, followed by a review of 23 published clinical studies in which various marketed bromfenac formulations were used for conditions other than cataract surgery or pseudophakic CME. These include: post-refractive eye surgery; macular edema associated with diabetes, uveitis, or retinal vein occlusion; inflammation associated with age-related macular degeneration; pain related to intravitreal injections; and other ocular anterior segment and surface disorders with an inflammatory component. The published evidence reviewed supports the safety and effectiveness of bromfenac in these additional ophthalmic indications. Bromfenac was well tolerated when given alone or in combination with intravitreal anti-vascular endothelial growth factor agents, topical corticosteroids, or topical mast-cell stabilizers. The most common adverse event reported was ocular irritation. No serious adverse events (ie, corneal epithelial disorders) were reported, although the majority of studies did not systematically evaluate potential side effects. Corneal complications, such as melts reported with diclofenac and ketorolac, were not observed with bromfenac in the studies. In summary, published study data support the clinical utility of bromfenac in various ocular disorders beyond post-cataract surgery. Additional studies are warranted to further define the potential role of bromfenac ophthalmic solution in clinical practice.Keywords: bromfenac, clinical studies, ocular inflammation, pain, safetySchechter BADove Medical Pressarticlebromfenacclinical studiesocular inflammationpainsafetyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1439-1460 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	bromfenac clinical studies ocular inflammation pain safety Ophthalmology RE1-994
spellingShingle	bromfenac clinical studies ocular inflammation pain safety Ophthalmology RE1-994 Schechter BA Use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies
description	Barry A SchechterCornea and Cataract Service, Florida Eye Microsurgical Institute, Boynton Beach, FL, USAAbstract: Topical ophthalmic nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat postoperative inflammation and pain following cataract surgery and for treatment and prophylaxis of pseudophakic cystoid macular edema (CME). Bromfenac is a brominated NSAID with strong in vitro anti-inflammatory potency. Like other ophthalmic NSAIDs, bromfenac is often used outside of the cataract surgery setting. This paper provides an overview of bromfenac’s preclinical ocular pharmacology and pharmacokinetics, followed by a review of 23 published clinical studies in which various marketed bromfenac formulations were used for conditions other than cataract surgery or pseudophakic CME. These include: post-refractive eye surgery; macular edema associated with diabetes, uveitis, or retinal vein occlusion; inflammation associated with age-related macular degeneration; pain related to intravitreal injections; and other ocular anterior segment and surface disorders with an inflammatory component. The published evidence reviewed supports the safety and effectiveness of bromfenac in these additional ophthalmic indications. Bromfenac was well tolerated when given alone or in combination with intravitreal anti-vascular endothelial growth factor agents, topical corticosteroids, or topical mast-cell stabilizers. The most common adverse event reported was ocular irritation. No serious adverse events (ie, corneal epithelial disorders) were reported, although the majority of studies did not systematically evaluate potential side effects. Corneal complications, such as melts reported with diclofenac and ketorolac, were not observed with bromfenac in the studies. In summary, published study data support the clinical utility of bromfenac in various ocular disorders beyond post-cataract surgery. Additional studies are warranted to further define the potential role of bromfenac ophthalmic solution in clinical practice.Keywords: bromfenac, clinical studies, ocular inflammation, pain, safety
format	article
author	Schechter BA
author_facet	Schechter BA
author_sort	Schechter BA
title	Use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies
title_short	Use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies
title_full	Use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies
title_fullStr	Use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies
title_full_unstemmed	Use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies
title_sort	use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/c99162c1e0de4c70bfd03d76bcb45647
work_keys_str_mv	AT schechterba useoftopicalbromfenacfortreatingocularpainandinflammationbeyondcataractsurgeryareviewofpublishedstudies
_version_	1718399602257821696

Use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies

Ejemplares similares