Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy

Abstract To study the alterations of sleep quality and circadian rhythm genes expressions upon elderly thyroid nodule patients, the risk factors associated with thyroid malignancies, and the potential relationship involved. The elderly people enrolled in our study were divided into three groups acco...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xudan Lou, Haidong Wang, Yanyuan Tu, Wen Tan, Cuiping Jiang, Jiao Sun, Zhijun Bao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c99270da16fc41a3b36a7b2730266102
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c99270da16fc41a3b36a7b2730266102
record_format	dspace
spelling	oai:doaj.org-article:c99270da16fc41a3b36a7b27302661022021-12-02T14:34:01ZAlterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy10.1038/s41598-021-93106-x2045-2322https://doaj.org/article/c99270da16fc41a3b36a7b27302661022021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93106-xhttps://doaj.org/toc/2045-2322Abstract To study the alterations of sleep quality and circadian rhythm genes expressions upon elderly thyroid nodule patients, the risk factors associated with thyroid malignancies, and the potential relationship involved. The elderly people enrolled in our study were divided into three groups according to the thyroid histopathology: malignant nodule group, benign nodule group, and normal group, and the clinical data and sleep quality were collected. Among the patients of surgery, 56 fresh thyroid tissues were collected for real-time PCR, immunohistochemistry and western blotting analysis of CLOCK, BMAL1, CRYs and PERs. Poor sleep quality, sleep latency and daytime dysfunction were the independent risk factors of malignant nodule after adjusted by other impacts. The expression levels of CLOCK, BMAL1 and PER2 in thyroid malignant group were significantly higher than benign and normal groups, while CRY2 was decreased, p < 0.05. In addition, CLOCK and BMAL1 protein levels were positively correlated with PSQI of corresponding patients and CRY2 was negatively correlated. Circadian rhythm genes mainly altered in malignant nodules, and sleep disorders may be involved in the occurrence of elderly thyroid malignancy through the high expressions of CLOCK and BMAL1, and low expression of CRY2.Xudan LouHaidong WangYanyuan TuWen TanCuiping JiangJiao SunZhijun BaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xudan Lou Haidong Wang Yanyuan Tu Wen Tan Cuiping Jiang Jiao Sun Zhijun Bao Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy
description	Abstract To study the alterations of sleep quality and circadian rhythm genes expressions upon elderly thyroid nodule patients, the risk factors associated with thyroid malignancies, and the potential relationship involved. The elderly people enrolled in our study were divided into three groups according to the thyroid histopathology: malignant nodule group, benign nodule group, and normal group, and the clinical data and sleep quality were collected. Among the patients of surgery, 56 fresh thyroid tissues were collected for real-time PCR, immunohistochemistry and western blotting analysis of CLOCK, BMAL1, CRYs and PERs. Poor sleep quality, sleep latency and daytime dysfunction were the independent risk factors of malignant nodule after adjusted by other impacts. The expression levels of CLOCK, BMAL1 and PER2 in thyroid malignant group were significantly higher than benign and normal groups, while CRY2 was decreased, p < 0.05. In addition, CLOCK and BMAL1 protein levels were positively correlated with PSQI of corresponding patients and CRY2 was negatively correlated. Circadian rhythm genes mainly altered in malignant nodules, and sleep disorders may be involved in the occurrence of elderly thyroid malignancy through the high expressions of CLOCK and BMAL1, and low expression of CRY2.
format	article
author	Xudan Lou Haidong Wang Yanyuan Tu Wen Tan Cuiping Jiang Jiao Sun Zhijun Bao
author_facet	Xudan Lou Haidong Wang Yanyuan Tu Wen Tan Cuiping Jiang Jiao Sun Zhijun Bao
author_sort	Xudan Lou
title	Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy
title_short	Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy
title_full	Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy
title_fullStr	Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy
title_full_unstemmed	Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy
title_sort	alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c99270da16fc41a3b36a7b2730266102
work_keys_str_mv	AT xudanlou alterationsofsleepqualityandcircadianrhythmgenesexpressioninelderlythyroidnodulepatientsandrisksassociatedwiththyroidmalignancy AT haidongwang alterationsofsleepqualityandcircadianrhythmgenesexpressioninelderlythyroidnodulepatientsandrisksassociatedwiththyroidmalignancy AT yanyuantu alterationsofsleepqualityandcircadianrhythmgenesexpressioninelderlythyroidnodulepatientsandrisksassociatedwiththyroidmalignancy AT wentan alterationsofsleepqualityandcircadianrhythmgenesexpressioninelderlythyroidnodulepatientsandrisksassociatedwiththyroidmalignancy AT cuipingjiang alterationsofsleepqualityandcircadianrhythmgenesexpressioninelderlythyroidnodulepatientsandrisksassociatedwiththyroidmalignancy AT jiaosun alterationsofsleepqualityandcircadianrhythmgenesexpressioninelderlythyroidnodulepatientsandrisksassociatedwiththyroidmalignancy AT zhijunbao alterationsofsleepqualityandcircadianrhythmgenesexpressioninelderlythyroidnodulepatientsandrisksassociatedwiththyroidmalignancy
_version_	1718391158249357312

Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy

Ejemplares similares