EFFECT OF EXTRACTION TECHNIQUE OF RUTA <I>GRAVEOLENS</I> ON ANTITYROSINASE ACTIVITY AND CORRELATION AMONGST INHIBITORY ACTIVITY, PHENOLIC COMPOUNDS CONTENT AND CYTOTOXICITY

Skin pigmentation is the consequence of melanin production and dispersion, this pigment is formed by a successive oxidation of L-Tyrosine into L-Dihydroxyphenylalanine (L-DOPA) and dopaquinone by Tyrosinase enzyme. Skin pigmentation irregularities become an aesthetic problem for many people. Therefo...

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Autores principales:	Katalina MUÑOZ D., Julián A. LONDOÑO L., Gabriel J. ARANGO A., Jelver A. SIERRA R., Karent E. BRAVO M.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Cytotoxicity tyrosinase inhibition Ruta graveolens skin lightening agents Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/c999210969204401a79ee8bbae647dba
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spelling	oai:doaj.org-article:c999210969204401a79ee8bbae647dba2021-11-19T04:20:47ZEFFECT OF EXTRACTION TECHNIQUE OF RUTA <I>GRAVEOLENS</I> ON ANTITYROSINASE ACTIVITY AND CORRELATION AMONGST INHIBITORY ACTIVITY, PHENOLIC COMPOUNDS CONTENT AND CYTOTOXICITY0121-40042145-2660https://doaj.org/article/c999210969204401a79ee8bbae647dba2009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/616https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Skin pigmentation is the consequence of melanin production and dispersion, this pigment is formed by a successive oxidation of L-Tyrosine into L-Dihydroxyphenylalanine (L-DOPA) and dopaquinone by Tyrosinase enzyme. Skin pigmentation irregularities become an aesthetic problem for many people. Therefore there is a big interest in research on products with skin lightening properties. In order to find inhibitors of Tyrosinase enzyme from natural product, extracts of Ruta graveolens (R. graveolens) were studied by using different extraction methods. The inhibition of the oxidation of L-Tyrosine catalyzed by mushroom tyrosinase is determined and correlated with cytotoxicity and the content of phenolic compounds, because inhibitory activity on the enzyme has been reported of these kind of compounds. It was found that the extraction method affects strongly the content of phenolic compounds of the extract and the cytotoxicity as well, in contrast with the inhibition of tyrosinase activity which remains almost unaffected. Katalina MUÑOZ D.Julián A. LONDOÑO L.Gabriel J. ARANGO A.Jelver A. SIERRA R.Karent E. BRAVO M.Universidad de AntioquiaarticleCytotoxicitytyrosinase inhibitionRuta graveolensskin lightening agentsFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 14, Iss 2 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytotoxicity tyrosinase inhibition Ruta graveolens skin lightening agents Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Cytotoxicity tyrosinase inhibition Ruta graveolens skin lightening agents Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Katalina MUÑOZ D. Julián A. LONDOÑO L. Gabriel J. ARANGO A. Jelver A. SIERRA R. Karent E. BRAVO M. EFFECT OF EXTRACTION TECHNIQUE OF RUTA <I>GRAVEOLENS</I> ON ANTITYROSINASE ACTIVITY AND CORRELATION AMONGST INHIBITORY ACTIVITY, PHENOLIC COMPOUNDS CONTENT AND CYTOTOXICITY
description	Skin pigmentation is the consequence of melanin production and dispersion, this pigment is formed by a successive oxidation of L-Tyrosine into L-Dihydroxyphenylalanine (L-DOPA) and dopaquinone by Tyrosinase enzyme. Skin pigmentation irregularities become an aesthetic problem for many people. Therefore there is a big interest in research on products with skin lightening properties. In order to find inhibitors of Tyrosinase enzyme from natural product, extracts of Ruta graveolens (R. graveolens) were studied by using different extraction methods. The inhibition of the oxidation of L-Tyrosine catalyzed by mushroom tyrosinase is determined and correlated with cytotoxicity and the content of phenolic compounds, because inhibitory activity on the enzyme has been reported of these kind of compounds. It was found that the extraction method affects strongly the content of phenolic compounds of the extract and the cytotoxicity as well, in contrast with the inhibition of tyrosinase activity which remains almost unaffected.
format	article
author	Katalina MUÑOZ D. Julián A. LONDOÑO L. Gabriel J. ARANGO A. Jelver A. SIERRA R. Karent E. BRAVO M.
author_facet	Katalina MUÑOZ D. Julián A. LONDOÑO L. Gabriel J. ARANGO A. Jelver A. SIERRA R. Karent E. BRAVO M.
author_sort	Katalina MUÑOZ D.
title	EFFECT OF EXTRACTION TECHNIQUE OF RUTA <I>GRAVEOLENS</I> ON ANTITYROSINASE ACTIVITY AND CORRELATION AMONGST INHIBITORY ACTIVITY, PHENOLIC COMPOUNDS CONTENT AND CYTOTOXICITY
title_short	EFFECT OF EXTRACTION TECHNIQUE OF RUTA <I>GRAVEOLENS</I> ON ANTITYROSINASE ACTIVITY AND CORRELATION AMONGST INHIBITORY ACTIVITY, PHENOLIC COMPOUNDS CONTENT AND CYTOTOXICITY
title_full	EFFECT OF EXTRACTION TECHNIQUE OF RUTA <I>GRAVEOLENS</I> ON ANTITYROSINASE ACTIVITY AND CORRELATION AMONGST INHIBITORY ACTIVITY, PHENOLIC COMPOUNDS CONTENT AND CYTOTOXICITY
title_fullStr	EFFECT OF EXTRACTION TECHNIQUE OF RUTA <I>GRAVEOLENS</I> ON ANTITYROSINASE ACTIVITY AND CORRELATION AMONGST INHIBITORY ACTIVITY, PHENOLIC COMPOUNDS CONTENT AND CYTOTOXICITY
title_full_unstemmed	EFFECT OF EXTRACTION TECHNIQUE OF RUTA <I>GRAVEOLENS</I> ON ANTITYROSINASE ACTIVITY AND CORRELATION AMONGST INHIBITORY ACTIVITY, PHENOLIC COMPOUNDS CONTENT AND CYTOTOXICITY
title_sort	effect of extraction technique of ruta <i>graveolens</i> on antityrosinase activity and correlation amongst inhibitory activity, phenolic compounds content and cytotoxicity
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/c999210969204401a79ee8bbae647dba
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EFFECT OF EXTRACTION TECHNIQUE OF RUTA <I>GRAVEOLENS</I> ON ANTITYROSINASE ACTIVITY AND CORRELATION AMONGST INHIBITORY ACTIVITY, PHENOLIC COMPOUNDS CONTENT AND CYTOTOXICITY

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