Characterization of the targeting signal in mitochondrial β-barrel proteins

Mitochondrial β-barrel proteins are synthesized in the cytosol before being targeted to the organelle. Here, Jores et al.show that a specialized hydrophobic β-hairpin motif is the previously undefined targeting sequence and is recognized by the mitochondrial outer membrane translocase.

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Autores principales:	Tobias Jores, Anna Klinger, Lucia E. Groß, Shin Kawano, Nadine Flinner, Elke Duchardt-Ferner, Jens Wöhnert, Hubert Kalbacher, Toshiya Endo, Enrico Schleiff, Doron Rapaport
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9998c7467d44b55904de822a28f1633
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spelling	oai:doaj.org-article:c9998c7467d44b55904de822a28f16332021-12-02T14:40:10ZCharacterization of the targeting signal in mitochondrial β-barrel proteins10.1038/ncomms120362041-1723https://doaj.org/article/c9998c7467d44b55904de822a28f16332016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12036https://doaj.org/toc/2041-1723Mitochondrial β-barrel proteins are synthesized in the cytosol before being targeted to the organelle. Here, Jores et al.show that a specialized hydrophobic β-hairpin motif is the previously undefined targeting sequence and is recognized by the mitochondrial outer membrane translocase.Tobias JoresAnna KlingerLucia E. GroßShin KawanoNadine FlinnerElke Duchardt-FernerJens WöhnertHubert KalbacherToshiya EndoEnrico SchleiffDoron RapaportNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tobias Jores Anna Klinger Lucia E. Groß Shin Kawano Nadine Flinner Elke Duchardt-Ferner Jens Wöhnert Hubert Kalbacher Toshiya Endo Enrico Schleiff Doron Rapaport Characterization of the targeting signal in mitochondrial β-barrel proteins
description	Mitochondrial β-barrel proteins are synthesized in the cytosol before being targeted to the organelle. Here, Jores et al.show that a specialized hydrophobic β-hairpin motif is the previously undefined targeting sequence and is recognized by the mitochondrial outer membrane translocase.
format	article
author	Tobias Jores Anna Klinger Lucia E. Groß Shin Kawano Nadine Flinner Elke Duchardt-Ferner Jens Wöhnert Hubert Kalbacher Toshiya Endo Enrico Schleiff Doron Rapaport
author_facet	Tobias Jores Anna Klinger Lucia E. Groß Shin Kawano Nadine Flinner Elke Duchardt-Ferner Jens Wöhnert Hubert Kalbacher Toshiya Endo Enrico Schleiff Doron Rapaport
author_sort	Tobias Jores
title	Characterization of the targeting signal in mitochondrial β-barrel proteins
title_short	Characterization of the targeting signal in mitochondrial β-barrel proteins
title_full	Characterization of the targeting signal in mitochondrial β-barrel proteins
title_fullStr	Characterization of the targeting signal in mitochondrial β-barrel proteins
title_full_unstemmed	Characterization of the targeting signal in mitochondrial β-barrel proteins
title_sort	characterization of the targeting signal in mitochondrial β-barrel proteins
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c9998c7467d44b55904de822a28f1633
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Characterization of the targeting signal in mitochondrial β-barrel proteins

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