Structural basis of ribosomal RNA transcription regulation

Ribosomal RNA (rRNA) expression is regulated at the initiation stage of RNA synthesis. Here, the authors report cryo-EM structures of E. coli RNA polymerase and rRNA promoter complex with DksA/ppGpp on the way to open complex formation, identifying key steps in promoter recognition and opening.

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Autores principales:	Yeonoh Shin, M. Zuhaib Qayyum, Danil Pupov, Daria Esyunina, Andrey Kulbachinskiy, Katsuhiko S. Murakami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c99ba2ef42594e0db946ed135fb5c245
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spelling	oai:doaj.org-article:c99ba2ef42594e0db946ed135fb5c2452021-12-02T13:57:11ZStructural basis of ribosomal RNA transcription regulation10.1038/s41467-020-20776-y2041-1723https://doaj.org/article/c99ba2ef42594e0db946ed135fb5c2452021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20776-yhttps://doaj.org/toc/2041-1723Ribosomal RNA (rRNA) expression is regulated at the initiation stage of RNA synthesis. Here, the authors report cryo-EM structures of E. coli RNA polymerase and rRNA promoter complex with DksA/ppGpp on the way to open complex formation, identifying key steps in promoter recognition and opening.Yeonoh ShinM. Zuhaib QayyumDanil PupovDaria EsyuninaAndrey KulbachinskiyKatsuhiko S. MurakamiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yeonoh Shin M. Zuhaib Qayyum Danil Pupov Daria Esyunina Andrey Kulbachinskiy Katsuhiko S. Murakami Structural basis of ribosomal RNA transcription regulation
description	Ribosomal RNA (rRNA) expression is regulated at the initiation stage of RNA synthesis. Here, the authors report cryo-EM structures of E. coli RNA polymerase and rRNA promoter complex with DksA/ppGpp on the way to open complex formation, identifying key steps in promoter recognition and opening.
format	article
author	Yeonoh Shin M. Zuhaib Qayyum Danil Pupov Daria Esyunina Andrey Kulbachinskiy Katsuhiko S. Murakami
author_facet	Yeonoh Shin M. Zuhaib Qayyum Danil Pupov Daria Esyunina Andrey Kulbachinskiy Katsuhiko S. Murakami
author_sort	Yeonoh Shin
title	Structural basis of ribosomal RNA transcription regulation
title_short	Structural basis of ribosomal RNA transcription regulation
title_full	Structural basis of ribosomal RNA transcription regulation
title_fullStr	Structural basis of ribosomal RNA transcription regulation
title_full_unstemmed	Structural basis of ribosomal RNA transcription regulation
title_sort	structural basis of ribosomal rna transcription regulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c99ba2ef42594e0db946ed135fb5c245
work_keys_str_mv	AT yeonohshin structuralbasisofribosomalrnatranscriptionregulation AT mzuhaibqayyum structuralbasisofribosomalrnatranscriptionregulation AT danilpupov structuralbasisofribosomalrnatranscriptionregulation AT dariaesyunina structuralbasisofribosomalrnatranscriptionregulation AT andreykulbachinskiy structuralbasisofribosomalrnatranscriptionregulation AT katsuhikosmurakami structuralbasisofribosomalrnatranscriptionregulation
_version_	1718392346803961856

Structural basis of ribosomal RNA transcription regulation

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