Species difference of CD137 ligand signaling in human and murine monocytes.

<h4>Background</h4>Stimulation of CD137 ligand on human monocytes has been shown to induce DC differentiation, and these CD137L-DCs are more potent than classical DCs, in stimulating T cell responses in vitro. To allow an in vivo evaluation of the potency of CD137L-DCs in murine models w...

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Autores principales:	Qianqiao Tang, Dongsheng Jiang, Zhe Shao, Julia M Martínez Gómez, Herbert Schwarz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c99dc1d926af40d2976c0d8fd6277482
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spelling	oai:doaj.org-article:c99dc1d926af40d2976c0d8fd62774822021-11-18T07:00:28ZSpecies difference of CD137 ligand signaling in human and murine monocytes.1932-620310.1371/journal.pone.0016129https://doaj.org/article/c99dc1d926af40d2976c0d8fd62774822011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21264248/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Stimulation of CD137 ligand on human monocytes has been shown to induce DC differentiation, and these CD137L-DCs are more potent than classical DCs, in stimulating T cell responses in vitro. To allow an in vivo evaluation of the potency of CD137L-DCs in murine models we aimed at generating murine CD137L-DCs.<h4>Methodology/principal findings</h4>When stimulated through CD137 ligand murine monocytes responded just as human monocytes with an increased adherence, morphological changes, proliferation and an increase in viable cell numbers. But CD137 ligand signaling did not induce expression of inflammatory cytokines and costimulatory molecules in murine monocytes and these cells had no T cell stimulatory activity. Murine monocytes did not differentiate to inflammatory DCs upon CD137 ligand signaling. Furthermore, while CD137 ligand signaling induces maturation of human immature classical DCs it failed to do so with murine immature classical DCs.<h4>Conclusions/significance</h4>These data demonstrate that both human and murine monocytes become activated by CD137 ligand signaling but only human and not murine monocytes differentiate to inflammatory DCs.Qianqiao TangDongsheng JiangZhe ShaoJulia M Martínez GómezHerbert SchwarzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 1, p e16129 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qianqiao Tang Dongsheng Jiang Zhe Shao Julia M Martínez Gómez Herbert Schwarz Species difference of CD137 ligand signaling in human and murine monocytes.
description	<h4>Background</h4>Stimulation of CD137 ligand on human monocytes has been shown to induce DC differentiation, and these CD137L-DCs are more potent than classical DCs, in stimulating T cell responses in vitro. To allow an in vivo evaluation of the potency of CD137L-DCs in murine models we aimed at generating murine CD137L-DCs.<h4>Methodology/principal findings</h4>When stimulated through CD137 ligand murine monocytes responded just as human monocytes with an increased adherence, morphological changes, proliferation and an increase in viable cell numbers. But CD137 ligand signaling did not induce expression of inflammatory cytokines and costimulatory molecules in murine monocytes and these cells had no T cell stimulatory activity. Murine monocytes did not differentiate to inflammatory DCs upon CD137 ligand signaling. Furthermore, while CD137 ligand signaling induces maturation of human immature classical DCs it failed to do so with murine immature classical DCs.<h4>Conclusions/significance</h4>These data demonstrate that both human and murine monocytes become activated by CD137 ligand signaling but only human and not murine monocytes differentiate to inflammatory DCs.
format	article
author	Qianqiao Tang Dongsheng Jiang Zhe Shao Julia M Martínez Gómez Herbert Schwarz
author_facet	Qianqiao Tang Dongsheng Jiang Zhe Shao Julia M Martínez Gómez Herbert Schwarz
author_sort	Qianqiao Tang
title	Species difference of CD137 ligand signaling in human and murine monocytes.
title_short	Species difference of CD137 ligand signaling in human and murine monocytes.
title_full	Species difference of CD137 ligand signaling in human and murine monocytes.
title_fullStr	Species difference of CD137 ligand signaling in human and murine monocytes.
title_full_unstemmed	Species difference of CD137 ligand signaling in human and murine monocytes.
title_sort	species difference of cd137 ligand signaling in human and murine monocytes.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/c99dc1d926af40d2976c0d8fd6277482
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_version_	1718424070420168704

Species difference of CD137 ligand signaling in human and murine monocytes.

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