Assessment of Chaenomeles Maulei Fruit Juice Effects in Tests for Depression and Anxiety

Depression and anxiety are prevalent chronic psychiatric disorders affecting many people worldwide. Over the past decades, much attention has been drawn to herbal psychopharmacology, offering fewer adverse reactions. The main bioactive compounds in Chaenomeles maulei fruits are polyphenols known for...

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Autores principales:	Borisova V., Eftimov M., Valcheva-Kuzmanova S.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2019
Materias:	anxiety depression forced swim test chaenomeles maulei polyphenols Medicine R
Acceso en línea:	https://doaj.org/article/c99dd66d9c154a2685770e659f809e3a
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spelling	oai:doaj.org-article:c99dd66d9c154a2685770e659f809e3a2021-12-02T19:11:32ZAssessment of Chaenomeles Maulei Fruit Juice Effects in Tests for Depression and Anxiety0324-175010.2478/amb-2019-0006https://doaj.org/article/c99dd66d9c154a2685770e659f809e3a2019-02-01T00:00:00Zhttps://doi.org/10.2478/amb-2019-0006https://doaj.org/toc/0324-1750Depression and anxiety are prevalent chronic psychiatric disorders affecting many people worldwide. Over the past decades, much attention has been drawn to herbal psychopharmacology, offering fewer adverse reactions. The main bioactive compounds in Chaenomeles maulei fruits are polyphenols known for their behavioral effects. The objective of the present study was to assess Chaenomeles maulei fruit juice (CMFJ) effects in tests for anxiety and depression. The animals used were 32 male healthy Wistar rats treated orally with CMFJ for 16 days. They were divided in four groups of 8 animals. The control group received distilled water and the rest of the groups were treated with CMFJ at 2.5, 5 and 10 ml/kg doses. We assessed the social interaction time as a measure of anxiety and the immobility time in the forced swim test as a measure of behavioral despair. In the social interaction test, the 14 days administration of CMFJ did not produce any significant changes in the time spent in social interaction. After 16 days of administration all doses of CMFJ significantly decreased the immobility time of the rats (p < 0.05) in comparison to the control group. These results allow making the conclusion that CMFJ lacked anxiolytic activity, but showed an antidepressant-like effect.Borisova V.Eftimov M.Valcheva-Kuzmanova S.Sciendoarticleanxietydepressionforced swim testchaenomeles mauleipolyphenolsMedicineRENActa Medica Bulgarica, Vol 46, Iss 1, Pp 34-38 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	anxiety depression forced swim test chaenomeles maulei polyphenols Medicine R
spellingShingle	anxiety depression forced swim test chaenomeles maulei polyphenols Medicine R Borisova V. Eftimov M. Valcheva-Kuzmanova S. Assessment of Chaenomeles Maulei Fruit Juice Effects in Tests for Depression and Anxiety
description	Depression and anxiety are prevalent chronic psychiatric disorders affecting many people worldwide. Over the past decades, much attention has been drawn to herbal psychopharmacology, offering fewer adverse reactions. The main bioactive compounds in Chaenomeles maulei fruits are polyphenols known for their behavioral effects. The objective of the present study was to assess Chaenomeles maulei fruit juice (CMFJ) effects in tests for anxiety and depression. The animals used were 32 male healthy Wistar rats treated orally with CMFJ for 16 days. They were divided in four groups of 8 animals. The control group received distilled water and the rest of the groups were treated with CMFJ at 2.5, 5 and 10 ml/kg doses. We assessed the social interaction time as a measure of anxiety and the immobility time in the forced swim test as a measure of behavioral despair. In the social interaction test, the 14 days administration of CMFJ did not produce any significant changes in the time spent in social interaction. After 16 days of administration all doses of CMFJ significantly decreased the immobility time of the rats (p < 0.05) in comparison to the control group. These results allow making the conclusion that CMFJ lacked anxiolytic activity, but showed an antidepressant-like effect.
format	article
author	Borisova V. Eftimov M. Valcheva-Kuzmanova S.
author_facet	Borisova V. Eftimov M. Valcheva-Kuzmanova S.
author_sort	Borisova V.
title	Assessment of Chaenomeles Maulei Fruit Juice Effects in Tests for Depression and Anxiety
title_short	Assessment of Chaenomeles Maulei Fruit Juice Effects in Tests for Depression and Anxiety
title_full	Assessment of Chaenomeles Maulei Fruit Juice Effects in Tests for Depression and Anxiety
title_fullStr	Assessment of Chaenomeles Maulei Fruit Juice Effects in Tests for Depression and Anxiety
title_full_unstemmed	Assessment of Chaenomeles Maulei Fruit Juice Effects in Tests for Depression and Anxiety
title_sort	assessment of chaenomeles maulei fruit juice effects in tests for depression and anxiety
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/c99dd66d9c154a2685770e659f809e3a
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Assessment of Chaenomeles Maulei Fruit Juice Effects in Tests for Depression and Anxiety

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