Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

Aging is associated with impaired pancreatic islet function, increased risk of type 2 diabetes, and changes in DNA methylation. Here the authors find blood-based biomarkers that reflect age-associated DNA methylation changes in human pancreatic islets associated with insulin secretion and diabetes.

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Main Authors:	Karl Bacos, Linn Gillberg, Petr Volkov, Anders H Olsson, Torben Hansen, Oluf Pedersen, Anette Prior Gjesing, Hans Eiberg, Tiinamaija Tuomi, Peter Almgren, Leif Groop, Lena Eliasson, Allan Vaag, Tasnim Dayeh, Charlotte Ling
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/c99faccee14345d89d7f5d0eb1cd3eb0
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spelling	oai:doaj.org-article:c99faccee14345d89d7f5d0eb1cd3eb02021-12-02T14:40:12ZBlood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes10.1038/ncomms110892041-1723https://doaj.org/article/c99faccee14345d89d7f5d0eb1cd3eb02016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11089https://doaj.org/toc/2041-1723Aging is associated with impaired pancreatic islet function, increased risk of type 2 diabetes, and changes in DNA methylation. Here the authors find blood-based biomarkers that reflect age-associated DNA methylation changes in human pancreatic islets associated with insulin secretion and diabetes.Karl BacosLinn GillbergPetr VolkovAnders H OlssonTorben HansenOluf PedersenAnette Prior GjesingHans EibergTiinamaija TuomiPeter AlmgrenLeif GroopLena EliassonAllan VaagTasnim DayehCharlotte LingNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karl Bacos Linn Gillberg Petr Volkov Anders H Olsson Torben Hansen Oluf Pedersen Anette Prior Gjesing Hans Eiberg Tiinamaija Tuomi Peter Almgren Leif Groop Lena Eliasson Allan Vaag Tasnim Dayeh Charlotte Ling Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
description	Aging is associated with impaired pancreatic islet function, increased risk of type 2 diabetes, and changes in DNA methylation. Here the authors find blood-based biomarkers that reflect age-associated DNA methylation changes in human pancreatic islets associated with insulin secretion and diabetes.
format	article
author	Karl Bacos Linn Gillberg Petr Volkov Anders H Olsson Torben Hansen Oluf Pedersen Anette Prior Gjesing Hans Eiberg Tiinamaija Tuomi Peter Almgren Leif Groop Lena Eliasson Allan Vaag Tasnim Dayeh Charlotte Ling
author_facet	Karl Bacos Linn Gillberg Petr Volkov Anders H Olsson Torben Hansen Oluf Pedersen Anette Prior Gjesing Hans Eiberg Tiinamaija Tuomi Peter Almgren Leif Groop Lena Eliasson Allan Vaag Tasnim Dayeh Charlotte Ling
author_sort	Karl Bacos
title	Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
title_short	Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
title_full	Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
title_fullStr	Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
title_full_unstemmed	Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
title_sort	blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c99faccee14345d89d7f5d0eb1cd3eb0
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Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

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