Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions

It is unknown how endocardium growth is coordinated with that of the myocardium in the zebrafish. Here, the authors show that myocardial chamber volume expansion causes increased endocardial tissue tension, which in turn triggers Hippo signaling-mediated proliferation within the endocardium.

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Autores principales:	Dorothee Bornhorst, Peng Xia, Hiroyuki Nakajima, Chaitanya Dingare, Wiebke Herzog, Virginie Lecaudey, Naoki Mochizuki, Carl-Philipp Heisenberg, Deborah Yelon, Salim Abdelilah-Seyfried
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9a01fbb92ac4026a8b8af2a31775f44
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spelling	oai:doaj.org-article:c9a01fbb92ac4026a8b8af2a31775f442021-12-02T14:39:58ZBiomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions10.1038/s41467-019-12068-x2041-1723https://doaj.org/article/c9a01fbb92ac4026a8b8af2a31775f442019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12068-xhttps://doaj.org/toc/2041-1723It is unknown how endocardium growth is coordinated with that of the myocardium in the zebrafish. Here, the authors show that myocardial chamber volume expansion causes increased endocardial tissue tension, which in turn triggers Hippo signaling-mediated proliferation within the endocardium.Dorothee BornhorstPeng XiaHiroyuki NakajimaChaitanya DingareWiebke HerzogVirginie LecaudeyNaoki MochizukiCarl-Philipp HeisenbergDeborah YelonSalim Abdelilah-SeyfriedNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dorothee Bornhorst Peng Xia Hiroyuki Nakajima Chaitanya Dingare Wiebke Herzog Virginie Lecaudey Naoki Mochizuki Carl-Philipp Heisenberg Deborah Yelon Salim Abdelilah-Seyfried Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions
description	It is unknown how endocardium growth is coordinated with that of the myocardium in the zebrafish. Here, the authors show that myocardial chamber volume expansion causes increased endocardial tissue tension, which in turn triggers Hippo signaling-mediated proliferation within the endocardium.
format	article
author	Dorothee Bornhorst Peng Xia Hiroyuki Nakajima Chaitanya Dingare Wiebke Herzog Virginie Lecaudey Naoki Mochizuki Carl-Philipp Heisenberg Deborah Yelon Salim Abdelilah-Seyfried
author_facet	Dorothee Bornhorst Peng Xia Hiroyuki Nakajima Chaitanya Dingare Wiebke Herzog Virginie Lecaudey Naoki Mochizuki Carl-Philipp Heisenberg Deborah Yelon Salim Abdelilah-Seyfried
author_sort	Dorothee Bornhorst
title	Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions
title_short	Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions
title_full	Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions
title_fullStr	Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions
title_full_unstemmed	Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions
title_sort	biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c9a01fbb92ac4026a8b8af2a31775f44
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Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions

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