Prevalence and clinical characteristics of metabolically unhealthy obesity in an Iranian adult population

Karamatollah Rahmanian,1 Mohammad Shojaei,2 Abdolreza Sotoodeh Jahromi21Research Center for Social Determinants of Health, Community Medicine Department, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran; 2Research Center for Non-communicable Diseases, Internal Diseases Depart...

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Autores principales:	Rahmanian K, Shojaei M, Sotoodeh Jahromi A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Metabolically Healthy Metabolically Unhealthy Obesity Overweight Prevalence Iran Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c9a444e8119142d3bf89892088219454
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spelling	oai:doaj.org-article:c9a444e8119142d3bf898920882194542021-12-02T05:42:27ZPrevalence and clinical characteristics of metabolically unhealthy obesity in an Iranian adult population1178-7007https://doaj.org/article/c9a444e8119142d3bf898920882194542019-08-01T00:00:00Zhttps://www.dovepress.com/prevalence-and-clinical-characteristics-of-metabolically-unhealthy-obe-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Karamatollah Rahmanian,1 Mohammad Shojaei,2 Abdolreza Sotoodeh Jahromi21Research Center for Social Determinants of Health, Community Medicine Department, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran; 2Research Center for Non-communicable Diseases, Internal Diseases Department, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, IranPurpose: The incidence of obesity is globally increasing and it is a predisposing factor for morbidity and mortality. This study assessed the prevalence of metabolically unhealthy (MU) individuals and its determinants according to body mass index (BMI).Materials and method: In our cross-sectional study, 891 persons aged 30 years or older participated. Participants were classified as obese (BMI ≥30 kg/m2), overweight (BMI 25–<30 kg/m2 and normal weight (BMI <25 kg/m2). Metabolic health status was defined using four existing cardio-metabolic abnormalities (elevated blood pressure, elevated serum concentrations of triglyceride and fasting glucose and a low serum concentration of high density lipoprotein cholesterol). Then, two phenotypes were defined: healthy (existence of 0–1 cardio-metabolic abnormalities) and unhealthy (presence of 2 or more cardio-metabolic abnormalities).Result: Overall, 10.9% (95% confidence interval (CI): 8.8–13.0) and 7.2% (95% CI: 5.5–8.9) of participants were MU obese and metabolically healthy obese, respectively. The prevalence of MU was higher in overweight (55.6%; 95% CI: 50.6–60.6, p<0.001) and obese (60.2%; 95% CI: 52.8–67.6, p=0.001) subjects than in individuals with a normal weight (37.5%; 95% CI: 29.4–42.6). Multiple logistic regression analysis showed an association of a MU state with age and dyslipidaemia in the BMI subgroups and with female sex in the normal weight individuals.Conclusion: The prevalence of a MU state increased with increasing BMI. Ageing and dyslipidaemia were associated with an unhealthy metabolic state in normal weight, overweight and obese subjects and with the female sex in normal weight subjects.Keywords: metabolically healthy, metabolically unhealthy, obesity, overweight, prevalence, IranRahmanian KShojaei MSotoodeh Jahromi ADove Medical PressarticleMetabolically HealthyMetabolically UnhealthyObesityOverweightPrevalenceIranSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1387-1395 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Metabolically Healthy Metabolically Unhealthy Obesity Overweight Prevalence Iran Specialties of internal medicine RC581-951
spellingShingle	Metabolically Healthy Metabolically Unhealthy Obesity Overweight Prevalence Iran Specialties of internal medicine RC581-951 Rahmanian K Shojaei M Sotoodeh Jahromi A Prevalence and clinical characteristics of metabolically unhealthy obesity in an Iranian adult population
description	Karamatollah Rahmanian,1 Mohammad Shojaei,2 Abdolreza Sotoodeh Jahromi21Research Center for Social Determinants of Health, Community Medicine Department, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran; 2Research Center for Non-communicable Diseases, Internal Diseases Department, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, IranPurpose: The incidence of obesity is globally increasing and it is a predisposing factor for morbidity and mortality. This study assessed the prevalence of metabolically unhealthy (MU) individuals and its determinants according to body mass index (BMI).Materials and method: In our cross-sectional study, 891 persons aged 30 years or older participated. Participants were classified as obese (BMI ≥30 kg/m2), overweight (BMI 25–<30 kg/m2 and normal weight (BMI <25 kg/m2). Metabolic health status was defined using four existing cardio-metabolic abnormalities (elevated blood pressure, elevated serum concentrations of triglyceride and fasting glucose and a low serum concentration of high density lipoprotein cholesterol). Then, two phenotypes were defined: healthy (existence of 0–1 cardio-metabolic abnormalities) and unhealthy (presence of 2 or more cardio-metabolic abnormalities).Result: Overall, 10.9% (95% confidence interval (CI): 8.8–13.0) and 7.2% (95% CI: 5.5–8.9) of participants were MU obese and metabolically healthy obese, respectively. The prevalence of MU was higher in overweight (55.6%; 95% CI: 50.6–60.6, p<0.001) and obese (60.2%; 95% CI: 52.8–67.6, p=0.001) subjects than in individuals with a normal weight (37.5%; 95% CI: 29.4–42.6). Multiple logistic regression analysis showed an association of a MU state with age and dyslipidaemia in the BMI subgroups and with female sex in the normal weight individuals.Conclusion: The prevalence of a MU state increased with increasing BMI. Ageing and dyslipidaemia were associated with an unhealthy metabolic state in normal weight, overweight and obese subjects and with the female sex in normal weight subjects.Keywords: metabolically healthy, metabolically unhealthy, obesity, overweight, prevalence, Iran
format	article
author	Rahmanian K Shojaei M Sotoodeh Jahromi A
author_facet	Rahmanian K Shojaei M Sotoodeh Jahromi A
author_sort	Rahmanian K
title	Prevalence and clinical characteristics of metabolically unhealthy obesity in an Iranian adult population
title_short	Prevalence and clinical characteristics of metabolically unhealthy obesity in an Iranian adult population
title_full	Prevalence and clinical characteristics of metabolically unhealthy obesity in an Iranian adult population
title_fullStr	Prevalence and clinical characteristics of metabolically unhealthy obesity in an Iranian adult population
title_full_unstemmed	Prevalence and clinical characteristics of metabolically unhealthy obesity in an Iranian adult population
title_sort	prevalence and clinical characteristics of metabolically unhealthy obesity in an iranian adult population
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/c9a444e8119142d3bf89892088219454
work_keys_str_mv	AT rahmaniank prevalenceandclinicalcharacteristicsofmetabolicallyunhealthyobesityinaniranianadultpopulation AT shojaeim prevalenceandclinicalcharacteristicsofmetabolicallyunhealthyobesityinaniranianadultpopulation AT sotoodehjahromia prevalenceandclinicalcharacteristicsofmetabolicallyunhealthyobesityinaniranianadultpopulation
_version_	1718400257317928960

Prevalence and clinical characteristics of metabolically unhealthy obesity in an Iranian adult population

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