Genome-wide association study of trypanosome prevalence and morphometric traits in purebred and crossbred Baoulé cattle of Burkina Faso.

In this study, single-SNP GWAS analyses were conducted to find regions affecting tolerance against trypanosomosis and morphometrics traits in purebred and crossbred Baoulé cattle of Burkina Faso. The trypanosomosis status (positive and negative) and a wide set of morphological traits were recorded f...

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Autores principales:	Bernadette Yougbaré, Albert Soudré, Dominique Ouédraogo, Bienvenue L Zoma, Arnaud S R Tapsoba, Moumouni Sanou, Salifou Ouédraogo-Koné, Pamela A Burger, Maria Wurzinger, Negar Khayatzadeh, Hamidou H Tamboura, Okeyo Ally Mwai, Amadou Traoré, Johann Sölkner, Gábor Mészáros
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9a5e289797149dbbcd22db27a220b09
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spelling	oai:doaj.org-article:c9a5e289797149dbbcd22db27a220b092021-12-02T20:15:13ZGenome-wide association study of trypanosome prevalence and morphometric traits in purebred and crossbred Baoulé cattle of Burkina Faso.1932-620310.1371/journal.pone.0255089https://doaj.org/article/c9a5e289797149dbbcd22db27a220b092021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255089https://doaj.org/toc/1932-6203In this study, single-SNP GWAS analyses were conducted to find regions affecting tolerance against trypanosomosis and morphometrics traits in purebred and crossbred Baoulé cattle of Burkina Faso. The trypanosomosis status (positive and negative) and a wide set of morphological traits were recorded for purebred Baoulé and crossbred Zebu x Baoulé cattle, and genotyped with the Illumina Bovine SNP50 BeadChip. After quality control, 36,203 SNPs and 619 animals including 343 purebred Baoulé and 279 crossbreds were used for the GWAS analyses. Several important genes were found that can influence morphological parameters. Although there were no genes identified with a reported strong connection to size traits, many of them were previously identified in various growth-related studies. A re-occurring theme for the genes residing in the regions identified by the most significant SNPs was pleiotropic effect on growth of the body and the cardiovascular system. Regarding trypanosomosis tolerance, two potentially important regions were identified in purebred Baoulé on chromosomes 16 and 24, containing the CFH, CRBN, TRNT1 and, IL5RA genes, and one additional genomic region in Baoulé, x Zebu crossbreds on chromosome 5, containing MGAT4C and NTS. Almost all of these regions and genes were previously related to the trait of interest, while the CRBN gene was to our knowledge presented in the context of trypanosomiasis tolerance for the first time.Bernadette YougbaréAlbert SoudréDominique OuédraogoBienvenue L ZomaArnaud S R TapsobaMoumouni SanouSalifou Ouédraogo-KonéPamela A BurgerMaria WurzingerNegar KhayatzadehHamidou H TambouraOkeyo Ally MwaiAmadou TraoréJohann SölknerGábor MészárosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255089 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bernadette Yougbaré Albert Soudré Dominique Ouédraogo Bienvenue L Zoma Arnaud S R Tapsoba Moumouni Sanou Salifou Ouédraogo-Koné Pamela A Burger Maria Wurzinger Negar Khayatzadeh Hamidou H Tamboura Okeyo Ally Mwai Amadou Traoré Johann Sölkner Gábor Mészáros Genome-wide association study of trypanosome prevalence and morphometric traits in purebred and crossbred Baoulé cattle of Burkina Faso.
description	In this study, single-SNP GWAS analyses were conducted to find regions affecting tolerance against trypanosomosis and morphometrics traits in purebred and crossbred Baoulé cattle of Burkina Faso. The trypanosomosis status (positive and negative) and a wide set of morphological traits were recorded for purebred Baoulé and crossbred Zebu x Baoulé cattle, and genotyped with the Illumina Bovine SNP50 BeadChip. After quality control, 36,203 SNPs and 619 animals including 343 purebred Baoulé and 279 crossbreds were used for the GWAS analyses. Several important genes were found that can influence morphological parameters. Although there were no genes identified with a reported strong connection to size traits, many of them were previously identified in various growth-related studies. A re-occurring theme for the genes residing in the regions identified by the most significant SNPs was pleiotropic effect on growth of the body and the cardiovascular system. Regarding trypanosomosis tolerance, two potentially important regions were identified in purebred Baoulé on chromosomes 16 and 24, containing the CFH, CRBN, TRNT1 and, IL5RA genes, and one additional genomic region in Baoulé, x Zebu crossbreds on chromosome 5, containing MGAT4C and NTS. Almost all of these regions and genes were previously related to the trait of interest, while the CRBN gene was to our knowledge presented in the context of trypanosomiasis tolerance for the first time.
format	article
author	Bernadette Yougbaré Albert Soudré Dominique Ouédraogo Bienvenue L Zoma Arnaud S R Tapsoba Moumouni Sanou Salifou Ouédraogo-Koné Pamela A Burger Maria Wurzinger Negar Khayatzadeh Hamidou H Tamboura Okeyo Ally Mwai Amadou Traoré Johann Sölkner Gábor Mészáros
author_facet	Bernadette Yougbaré Albert Soudré Dominique Ouédraogo Bienvenue L Zoma Arnaud S R Tapsoba Moumouni Sanou Salifou Ouédraogo-Koné Pamela A Burger Maria Wurzinger Negar Khayatzadeh Hamidou H Tamboura Okeyo Ally Mwai Amadou Traoré Johann Sölkner Gábor Mészáros
author_sort	Bernadette Yougbaré
title	Genome-wide association study of trypanosome prevalence and morphometric traits in purebred and crossbred Baoulé cattle of Burkina Faso.
title_short	Genome-wide association study of trypanosome prevalence and morphometric traits in purebred and crossbred Baoulé cattle of Burkina Faso.
title_full	Genome-wide association study of trypanosome prevalence and morphometric traits in purebred and crossbred Baoulé cattle of Burkina Faso.
title_fullStr	Genome-wide association study of trypanosome prevalence and morphometric traits in purebred and crossbred Baoulé cattle of Burkina Faso.
title_full_unstemmed	Genome-wide association study of trypanosome prevalence and morphometric traits in purebred and crossbred Baoulé cattle of Burkina Faso.
title_sort	genome-wide association study of trypanosome prevalence and morphometric traits in purebred and crossbred baoulé cattle of burkina faso.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c9a5e289797149dbbcd22db27a220b09
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Genome-wide association study of trypanosome prevalence and morphometric traits in purebred and crossbred Baoulé cattle of Burkina Faso.

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