PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

Antibody mediated immune responses to Streptococcus pneumoniae are crucial for the immune response to infection. Here the authors show hyper-activation of PI3Kδ promotes development of a subset of B cells that exacerbate infection in an antibody-independent manner and can be reversed by therapeutic...

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Autores principales:	Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, Rafeah Alam, Valentina Carbonaro, Jonathan Clark, Srividya Sriskantharajah, Glyn Bradley, Alex G. Richter, Edward Banham-Hall, Menna R. Clatworthy, Sergey Nejentsev, J. Nicole Hamblin, Edith M. Hessel, Alison M. Condliffe, Klaus Okkenhaug
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9aa4017c3b04e369742fcdb03fa2a6c
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spelling	oai:doaj.org-article:c9aa4017c3b04e369742fcdb03fa2a6c2021-12-02T16:50:09ZPI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner10.1038/s41467-018-05674-82041-1723https://doaj.org/article/c9aa4017c3b04e369742fcdb03fa2a6c2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05674-8https://doaj.org/toc/2041-1723Antibody mediated immune responses to Streptococcus pneumoniae are crucial for the immune response to infection. Here the authors show hyper-activation of PI3Kδ promotes development of a subset of B cells that exacerbate infection in an antibody-independent manner and can be reversed by therapeutic targeting in vivo.Anne-Katrien StarkAnita ChandraKrishnendu ChakrabortyRafeah AlamValentina CarbonaroJonathan ClarkSrividya SriskantharajahGlyn BradleyAlex G. RichterEdward Banham-HallMenna R. ClatworthySergey NejentsevJ. Nicole HamblinEdith M. HesselAlison M. CondliffeKlaus OkkenhaugNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anne-Katrien Stark Anita Chandra Krishnendu Chakraborty Rafeah Alam Valentina Carbonaro Jonathan Clark Srividya Sriskantharajah Glyn Bradley Alex G. Richter Edward Banham-Hall Menna R. Clatworthy Sergey Nejentsev J. Nicole Hamblin Edith M. Hessel Alison M. Condliffe Klaus Okkenhaug PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
description	Antibody mediated immune responses to Streptococcus pneumoniae are crucial for the immune response to infection. Here the authors show hyper-activation of PI3Kδ promotes development of a subset of B cells that exacerbate infection in an antibody-independent manner and can be reversed by therapeutic targeting in vivo.
format	article
author	Anne-Katrien Stark Anita Chandra Krishnendu Chakraborty Rafeah Alam Valentina Carbonaro Jonathan Clark Srividya Sriskantharajah Glyn Bradley Alex G. Richter Edward Banham-Hall Menna R. Clatworthy Sergey Nejentsev J. Nicole Hamblin Edith M. Hessel Alison M. Condliffe Klaus Okkenhaug
author_facet	Anne-Katrien Stark Anita Chandra Krishnendu Chakraborty Rafeah Alam Valentina Carbonaro Jonathan Clark Srividya Sriskantharajah Glyn Bradley Alex G. Richter Edward Banham-Hall Menna R. Clatworthy Sergey Nejentsev J. Nicole Hamblin Edith M. Hessel Alison M. Condliffe Klaus Okkenhaug
author_sort	Anne-Katrien Stark
title	PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
title_short	PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
title_full	PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
title_fullStr	PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
title_full_unstemmed	PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
title_sort	pi3kδ hyper-activation promotes development of b cells that exacerbate streptococcus pneumoniae infection in an antibody-independent manner
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c9aa4017c3b04e369742fcdb03fa2a6c
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PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

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