Alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol

Abstract In recent years there has been a growing demand for the development of agrochemical controlled release (CR) technologies. In the present study, we aimed to create a novel agricultural CR device using two polymeric systems that have been predominantly employed in biomedical applications: bea...

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Autores principales:	Alexandra Mun, Haneen Simaan Yameen, Giora Edelbaum, Dror Seliktar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9aed348db1d43c7a4188369ca58357e
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spelling	oai:doaj.org-article:c9aed348db1d43c7a4188369ca58357e2021-12-02T16:53:00ZAlginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol10.1038/s41598-021-90338-92045-2322https://doaj.org/article/c9aed348db1d43c7a4188369ca58357e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90338-9https://doaj.org/toc/2045-2322Abstract In recent years there has been a growing demand for the development of agrochemical controlled release (CR) technologies. In the present study, we aimed to create a novel agricultural CR device using two polymeric systems that have been predominantly employed in biomedical applications: beads of alginate hydrogel embedded with drug-bearing Polycaprolactone (PCL) microspheres. The combined device utilizes the advantages of each polymer type for biodegradation and controlled release of Paclobutrazol (PBZ), a common growth retardant in plants. Surface morphology of the alginate beads was characterized by scanning electron microscopy (SEM) and water immersion tests were performed for stability and controlled release measurements. Bioassays were performed both in accelerated laboratory conditions and in field conditions. The results showed a capability to control the size of PBZ-loaded PCL microspheres through modification of homogenization speed and emulsifier concentration. Enlargement of PCL microsphere size had an adverse effect on release of PBZ from the alginate device. The growth of oatmeal plants as a model system was affected by the controlled release of PBZ. The preliminary field experiment observed growth retardation during two consecutive rainy seasons, with results indicating a substantial benefit of the sustained growth inhibition through the controlled release formulation. The final product has the potential to be used as a carrier for different substances in the agrochemical industry.Alexandra MunHaneen Simaan YameenGiora EdelbaumDror SeliktarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexandra Mun Haneen Simaan Yameen Giora Edelbaum Dror Seliktar Alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol
description	Abstract In recent years there has been a growing demand for the development of agrochemical controlled release (CR) technologies. In the present study, we aimed to create a novel agricultural CR device using two polymeric systems that have been predominantly employed in biomedical applications: beads of alginate hydrogel embedded with drug-bearing Polycaprolactone (PCL) microspheres. The combined device utilizes the advantages of each polymer type for biodegradation and controlled release of Paclobutrazol (PBZ), a common growth retardant in plants. Surface morphology of the alginate beads was characterized by scanning electron microscopy (SEM) and water immersion tests were performed for stability and controlled release measurements. Bioassays were performed both in accelerated laboratory conditions and in field conditions. The results showed a capability to control the size of PBZ-loaded PCL microspheres through modification of homogenization speed and emulsifier concentration. Enlargement of PCL microsphere size had an adverse effect on release of PBZ from the alginate device. The growth of oatmeal plants as a model system was affected by the controlled release of PBZ. The preliminary field experiment observed growth retardation during two consecutive rainy seasons, with results indicating a substantial benefit of the sustained growth inhibition through the controlled release formulation. The final product has the potential to be used as a carrier for different substances in the agrochemical industry.
format	article
author	Alexandra Mun Haneen Simaan Yameen Giora Edelbaum Dror Seliktar
author_facet	Alexandra Mun Haneen Simaan Yameen Giora Edelbaum Dror Seliktar
author_sort	Alexandra Mun
title	Alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol
title_short	Alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol
title_full	Alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol
title_fullStr	Alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol
title_full_unstemmed	Alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol
title_sort	alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9aed348db1d43c7a4188369ca58357e
work_keys_str_mv	AT alexandramun alginatehydrogelbeadsembeddedwithdrugbearingpolycaprolactonemicrospheresforsustainedreleaseofpaclobutrazol AT haneensimaanyameen alginatehydrogelbeadsembeddedwithdrugbearingpolycaprolactonemicrospheresforsustainedreleaseofpaclobutrazol AT gioraedelbaum alginatehydrogelbeadsembeddedwithdrugbearingpolycaprolactonemicrospheresforsustainedreleaseofpaclobutrazol AT drorseliktar alginatehydrogelbeadsembeddedwithdrugbearingpolycaprolactonemicrospheresforsustainedreleaseofpaclobutrazol
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Alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol

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