NEW ASPECTS OF ASSESSMENT THE ACTIVITY OF BLOOD PHAGOCYTES IN PULMONARY TUBERCULOSIS

Abstract. The phagocytosis is the key mechanism of organism protection from Mycobacterium tuberculosis. The aim of the study is to assess the phagocytal activity of cells in lung tuberculosis by the flowing cytofluorometric method. Overall 39 patients were examined including 14 patients with infiltr...

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Autores principales:	S. N. Skornyakov, I. D. Medvinsky, O. V. Berdyugina, A. V. Ershova, V. A. Pavlov, E. V. Sabadash, I. A. Tuzankina, K. A. Berdyugin
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	tuberculosis activity of blood phagocytes Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/c9afe326c3ad4940b37ea655603c6047
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spelling	oai:doaj.org-article:c9afe326c3ad4940b37ea655603c60472021-11-22T07:09:46ZNEW ASPECTS OF ASSESSMENT THE ACTIVITY OF BLOOD PHAGOCYTES IN PULMONARY TUBERCULOSIS2220-76192313-739810.15789/2220-7619-2012-4-723-728https://doaj.org/article/c9afe326c3ad4940b37ea655603c60472014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/109https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The phagocytosis is the key mechanism of organism protection from Mycobacterium tuberculosis. The aim of the study is to assess the phagocytal activity of cells in lung tuberculosis by the flowing cytofluorometric method. Overall 39 patients were examined including 14 patients with infiltrative lung tuberculosis, 15 patients with tuberculoma, 10 healthy persons. The patient testing was provided by the machine COULTER®Epics®XL, reagents Phagotest® (Orpegen Pharma), BurstTestKit (Glycotope Biotechnology) and monoclonal antibodies to detect subpopulation of lymphocytes. All obtained data were statistically processed by the software STATISTICА. It was established that the assessment of phagocytal activity of cells is the important criteria of detection of tuberculosis activity in the early stages of observation as well as during the treatment. The flowing cytometria allows rapidly, accurately and objectively assess the phagocytal cells of blood. It was determined that markers of early activation of cells could reflect the activity of pathological process and it can be used for prognosis of clinical course of lung tuberculosis.S. N. SkornyakovI. D. MedvinskyO. V. BerdyuginaA. V. ErshovaV. A. PavlovE. V. SabadashI. A. TuzankinaK. A. BerdyuginSankt-Peterburg : NIIÈM imeni Pasteraarticletuberculosisactivity of blood phagocytesInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 2, Iss 4, Pp 723-728 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis activity of blood phagocytes Infectious and parasitic diseases RC109-216
spellingShingle	tuberculosis activity of blood phagocytes Infectious and parasitic diseases RC109-216 S. N. Skornyakov I. D. Medvinsky O. V. Berdyugina A. V. Ershova V. A. Pavlov E. V. Sabadash I. A. Tuzankina K. A. Berdyugin NEW ASPECTS OF ASSESSMENT THE ACTIVITY OF BLOOD PHAGOCYTES IN PULMONARY TUBERCULOSIS
description	Abstract. The phagocytosis is the key mechanism of organism protection from Mycobacterium tuberculosis. The aim of the study is to assess the phagocytal activity of cells in lung tuberculosis by the flowing cytofluorometric method. Overall 39 patients were examined including 14 patients with infiltrative lung tuberculosis, 15 patients with tuberculoma, 10 healthy persons. The patient testing was provided by the machine COULTER®Epics®XL, reagents Phagotest® (Orpegen Pharma), BurstTestKit (Glycotope Biotechnology) and monoclonal antibodies to detect subpopulation of lymphocytes. All obtained data were statistically processed by the software STATISTICА. It was established that the assessment of phagocytal activity of cells is the important criteria of detection of tuberculosis activity in the early stages of observation as well as during the treatment. The flowing cytometria allows rapidly, accurately and objectively assess the phagocytal cells of blood. It was determined that markers of early activation of cells could reflect the activity of pathological process and it can be used for prognosis of clinical course of lung tuberculosis.
format	article
author	S. N. Skornyakov I. D. Medvinsky O. V. Berdyugina A. V. Ershova V. A. Pavlov E. V. Sabadash I. A. Tuzankina K. A. Berdyugin
author_facet	S. N. Skornyakov I. D. Medvinsky O. V. Berdyugina A. V. Ershova V. A. Pavlov E. V. Sabadash I. A. Tuzankina K. A. Berdyugin
author_sort	S. N. Skornyakov
title	NEW ASPECTS OF ASSESSMENT THE ACTIVITY OF BLOOD PHAGOCYTES IN PULMONARY TUBERCULOSIS
title_short	NEW ASPECTS OF ASSESSMENT THE ACTIVITY OF BLOOD PHAGOCYTES IN PULMONARY TUBERCULOSIS
title_full	NEW ASPECTS OF ASSESSMENT THE ACTIVITY OF BLOOD PHAGOCYTES IN PULMONARY TUBERCULOSIS
title_fullStr	NEW ASPECTS OF ASSESSMENT THE ACTIVITY OF BLOOD PHAGOCYTES IN PULMONARY TUBERCULOSIS
title_full_unstemmed	NEW ASPECTS OF ASSESSMENT THE ACTIVITY OF BLOOD PHAGOCYTES IN PULMONARY TUBERCULOSIS
title_sort	new aspects of assessment the activity of blood phagocytes in pulmonary tuberculosis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/c9afe326c3ad4940b37ea655603c6047
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NEW ASPECTS OF ASSESSMENT THE ACTIVITY OF BLOOD PHAGOCYTES IN PULMONARY TUBERCULOSIS

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