Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses.

Investigating the complex systems dynamics of the aging process requires integration of a broad range of cellular processes describing damage and functional decline co-existing with adaptive and protective regulatory mechanisms. We evolve an integrated generic cell network to represent the connectiv...

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Autores principales: Andres Kriete, William J Bosl, Glenn Booker
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/c9b0d1145bcc48f8a85cd12cb540420b
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