Pre-diagnosis Cruciferous Vegetables and Isothiocyanates Intake and Ovarian Cancer Survival: A Prospective Cohort Study
Background: The associations of the consumption of cruciferous vegetables (CVs) and their bioactive components, isothiocyanates (ITCs), with ovarian cancer (OC) mortality have been unclear, owing to limited studies and inconsistent findings. To date, no studies have evaluated these associations amon...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:c9b0dac3dba44556b923a56b9c0a17052021-11-30T18:46:33ZPre-diagnosis Cruciferous Vegetables and Isothiocyanates Intake and Ovarian Cancer Survival: A Prospective Cohort Study2296-861X10.3389/fnut.2021.778031https://doaj.org/article/c9b0dac3dba44556b923a56b9c0a17052021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.778031/fullhttps://doaj.org/toc/2296-861XBackground: The associations of the consumption of cruciferous vegetables (CVs) and their bioactive components, isothiocyanates (ITCs), with ovarian cancer (OC) mortality have been unclear, owing to limited studies and inconsistent findings. To date, no studies have evaluated these associations among Chinese patients with OC. This study aims to provide more evidence indicating the relationships of pre-diagnosis CVs and ITC intake with OC survival.Methods: We examined the associations of pre-diagnosis CV and ITC intake with OC mortality in a hospital-based cohort (n = 853) of Chinese patients with epithelial OC between 2015 and 2020. Pre-diagnosis dietary information was evaluated with a validated food frequency questionnaire. Deaths were ascertained until March 31, 2021 via medical records and active follow-up. The associations were examined with the Cox proportional hazards model, adjusted for potential confounders, and stratified by menopausal status, residual lesions, histological type, and body mass index (BMI).Results: During a median follow-up of 37.2 months (interquartile: 24.7–50.2 months), we observed 130 deaths. The highest tertile of total CV intake was associated with better survival than the lowest tertile intake [hazard ratio (HR) = 0.57, 95% confidence interval (CI) = 0.33–0.98, p trend < 0.05]. In addition, higher intake of ITCs from CVs was associated with better survival (HRT3VS.T1 = 0.59, 95% CI = 0.36–0.99, p trend = 0.06). Significant inverse associations were also observed for subgroup analyses stratified by menopausal status, residual lesions, histological type, and BMI, although not all associations showed statistical significance.Conclusion: Increasing pre-diagnosis consumption of CVs and ITCs was strongly associated with better survival in patients with OC.Yi-Fan WeiYi-Fan WeiYing-Ying HaoSong GaoXiu-Qin LiFang-Hua LiuFang-Hua LiuZhao-Yan WenZhao-Yan WenHan-Yuan WangHan-Yuan WangShuang ZhangShuang ZhangShi YanShi YanMeng LuanMeng LuanMeng LuanYu-Hong ZhaoYu-Hong ZhaoTing-Ting GongQi-Jun WuQi-Jun WuFrontiers Media S.A.articlecohortcruciferous vegetablesisothiocyanatesovarian cancerprognosissurvivalNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021) |
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cohort cruciferous vegetables isothiocyanates ovarian cancer prognosis survival Nutrition. Foods and food supply TX341-641 |
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cohort cruciferous vegetables isothiocyanates ovarian cancer prognosis survival Nutrition. Foods and food supply TX341-641 Yi-Fan Wei Yi-Fan Wei Ying-Ying Hao Song Gao Xiu-Qin Li Fang-Hua Liu Fang-Hua Liu Zhao-Yan Wen Zhao-Yan Wen Han-Yuan Wang Han-Yuan Wang Shuang Zhang Shuang Zhang Shi Yan Shi Yan Meng Luan Meng Luan Meng Luan Yu-Hong Zhao Yu-Hong Zhao Ting-Ting Gong Qi-Jun Wu Qi-Jun Wu Pre-diagnosis Cruciferous Vegetables and Isothiocyanates Intake and Ovarian Cancer Survival: A Prospective Cohort Study |
| description |
Background: The associations of the consumption of cruciferous vegetables (CVs) and their bioactive components, isothiocyanates (ITCs), with ovarian cancer (OC) mortality have been unclear, owing to limited studies and inconsistent findings. To date, no studies have evaluated these associations among Chinese patients with OC. This study aims to provide more evidence indicating the relationships of pre-diagnosis CVs and ITC intake with OC survival.Methods: We examined the associations of pre-diagnosis CV and ITC intake with OC mortality in a hospital-based cohort (n = 853) of Chinese patients with epithelial OC between 2015 and 2020. Pre-diagnosis dietary information was evaluated with a validated food frequency questionnaire. Deaths were ascertained until March 31, 2021 via medical records and active follow-up. The associations were examined with the Cox proportional hazards model, adjusted for potential confounders, and stratified by menopausal status, residual lesions, histological type, and body mass index (BMI).Results: During a median follow-up of 37.2 months (interquartile: 24.7–50.2 months), we observed 130 deaths. The highest tertile of total CV intake was associated with better survival than the lowest tertile intake [hazard ratio (HR) = 0.57, 95% confidence interval (CI) = 0.33–0.98, p trend < 0.05]. In addition, higher intake of ITCs from CVs was associated with better survival (HRT3VS.T1 = 0.59, 95% CI = 0.36–0.99, p trend = 0.06). Significant inverse associations were also observed for subgroup analyses stratified by menopausal status, residual lesions, histological type, and BMI, although not all associations showed statistical significance.Conclusion: Increasing pre-diagnosis consumption of CVs and ITCs was strongly associated with better survival in patients with OC. |
| format |
article |
| author |
Yi-Fan Wei Yi-Fan Wei Ying-Ying Hao Song Gao Xiu-Qin Li Fang-Hua Liu Fang-Hua Liu Zhao-Yan Wen Zhao-Yan Wen Han-Yuan Wang Han-Yuan Wang Shuang Zhang Shuang Zhang Shi Yan Shi Yan Meng Luan Meng Luan Meng Luan Yu-Hong Zhao Yu-Hong Zhao Ting-Ting Gong Qi-Jun Wu Qi-Jun Wu |
| author_facet |
Yi-Fan Wei Yi-Fan Wei Ying-Ying Hao Song Gao Xiu-Qin Li Fang-Hua Liu Fang-Hua Liu Zhao-Yan Wen Zhao-Yan Wen Han-Yuan Wang Han-Yuan Wang Shuang Zhang Shuang Zhang Shi Yan Shi Yan Meng Luan Meng Luan Meng Luan Yu-Hong Zhao Yu-Hong Zhao Ting-Ting Gong Qi-Jun Wu Qi-Jun Wu |
| author_sort |
Yi-Fan Wei |
| title |
Pre-diagnosis Cruciferous Vegetables and Isothiocyanates Intake and Ovarian Cancer Survival: A Prospective Cohort Study |
| title_short |
Pre-diagnosis Cruciferous Vegetables and Isothiocyanates Intake and Ovarian Cancer Survival: A Prospective Cohort Study |
| title_full |
Pre-diagnosis Cruciferous Vegetables and Isothiocyanates Intake and Ovarian Cancer Survival: A Prospective Cohort Study |
| title_fullStr |
Pre-diagnosis Cruciferous Vegetables and Isothiocyanates Intake and Ovarian Cancer Survival: A Prospective Cohort Study |
| title_full_unstemmed |
Pre-diagnosis Cruciferous Vegetables and Isothiocyanates Intake and Ovarian Cancer Survival: A Prospective Cohort Study |
| title_sort |
pre-diagnosis cruciferous vegetables and isothiocyanates intake and ovarian cancer survival: a prospective cohort study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/c9b0dac3dba44556b923a56b9c0a1705 |
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