The Association Between Hyperlipidemia and In-Hospital Outcomes in Takotsubo Cardiomyopathy

Pengyang Li,1,* Xiaojia Lu,2,* Catherine Teng,3 Michelle Hadley,4 Peng Cai,5 Qiying Dai,5 Bin Wang2,6 1Department of Medicine, Saint Vincent Hospital, Worcester, MA 01608, USA; 2Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041,...

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Autores principales:	Li P, Lu X, Teng C, Hadley M, Cai P, Dai Q, Wang B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	takotsubo cardiomyopathy hyperlipidemia mortality Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c9b1e31be5ac4cb5bd9f40e31d19eb35
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spelling	oai:doaj.org-article:c9b1e31be5ac4cb5bd9f40e31d19eb352021-12-02T12:48:53ZThe Association Between Hyperlipidemia and In-Hospital Outcomes in Takotsubo Cardiomyopathy1178-7007https://doaj.org/article/c9b1e31be5ac4cb5bd9f40e31d19eb352021-01-01T00:00:00Zhttps://www.dovepress.com/the-association-between-hyperlipidemia-and-in-hospital-outcomes-in-tak-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Pengyang Li,1,* Xiaojia Lu,2,* Catherine Teng,3 Michelle Hadley,4 Peng Cai,5 Qiying Dai,5 Bin Wang2,6 1Department of Medicine, Saint Vincent Hospital, Worcester, MA 01608, USA; 2Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, People’s Republic of China; 3Department of Medicine, Yale New Haven Health-Greenwich Hospital, Greenwich, CT 06830, USA; 4Division of Cardiology, Saint Vincent Hospital, Worcester, MA 01608, USA; 5Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA 01609, USA; 6Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bin WangDepartment of Cardiology, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, Shantou, Guangdong 515041, People’s Republic of ChinaTel +86-75488905399Fax +86 75488259850Email wangbin_pku@126.comPurpose: Hyperlipidemia (HLD) is one of the most common cardiovascular risk factors and is prevalent in patients with takotsubo cardiomyopathy (TCM), but the association between HLD and TCM patients’ outcomes is unclear. We investigated the impact of HLD on the in-hospital outcomes of TCM patients.Patients and Methods: Our retrospective cohort study used the latest available data from the National Inpatient Sample (2016– 2017). Using the ICD-10 code, we identified 3139 patients with a primary diagnosis of TCM, 1530 of whom had HLD. We compared in-hospital outcomes between HLD and non-HLD groups before and after propensity score matching.Results: In the unmatched cohort, the HLD group had lower incidences of cardiac arrest, cardiogenic shock, and acute respiratory failure (ARF); shorter length of stay (LOS); and lower total charges (All p< 0.05). In-hospital mortality (p=0.102) and ventricular arrhythmia (p=0.235) rates did not differ. After propensity score matching, the HLD group had lower rates of in-hospital mortality (1.1% vs 2.4%, p=0.027), ARF (9.1% vs 12.1%, p = 0.022) and cardiogenic shock (3.4% vs 5.6%, p=0.012), shorter LOS (3.20 ± 3.27 days vs 3.57 ± 3.14 days, p=0.005), and lower total charges (p=0.013). The matched groups did not differ significantly regarding cardiac arrest (p=0.141), ventricular arrhythmia (p=0.662) or acute kidney injury (AKI) (p = 0.167).Conclusion: Counterintuitively, HLD was associated with better in-hospital outcomes in both the unmatched and propensity-matched cohorts of hospitalized TCM patients. Further studies are needed to investigate the mechanisms that may contribute to the association in TCM patients with HLD.Keywords: takotsubo cardiomyopathy, hyperlipidemia, mortalityLi PLu XTeng CHadley MCai PDai QWang BDove Medical Pressarticletakotsubo cardiomyopathyhyperlipidemiamortalitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 117-126 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	takotsubo cardiomyopathy hyperlipidemia mortality Specialties of internal medicine RC581-951
spellingShingle	takotsubo cardiomyopathy hyperlipidemia mortality Specialties of internal medicine RC581-951 Li P Lu X Teng C Hadley M Cai P Dai Q Wang B The Association Between Hyperlipidemia and In-Hospital Outcomes in Takotsubo Cardiomyopathy
description	Pengyang Li,1,* Xiaojia Lu,2,* Catherine Teng,3 Michelle Hadley,4 Peng Cai,5 Qiying Dai,5 Bin Wang2,6 1Department of Medicine, Saint Vincent Hospital, Worcester, MA 01608, USA; 2Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, People’s Republic of China; 3Department of Medicine, Yale New Haven Health-Greenwich Hospital, Greenwich, CT 06830, USA; 4Division of Cardiology, Saint Vincent Hospital, Worcester, MA 01608, USA; 5Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA 01609, USA; 6Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bin WangDepartment of Cardiology, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, Shantou, Guangdong 515041, People’s Republic of ChinaTel +86-75488905399Fax +86 75488259850Email wangbin_pku@126.comPurpose: Hyperlipidemia (HLD) is one of the most common cardiovascular risk factors and is prevalent in patients with takotsubo cardiomyopathy (TCM), but the association between HLD and TCM patients’ outcomes is unclear. We investigated the impact of HLD on the in-hospital outcomes of TCM patients.Patients and Methods: Our retrospective cohort study used the latest available data from the National Inpatient Sample (2016– 2017). Using the ICD-10 code, we identified 3139 patients with a primary diagnosis of TCM, 1530 of whom had HLD. We compared in-hospital outcomes between HLD and non-HLD groups before and after propensity score matching.Results: In the unmatched cohort, the HLD group had lower incidences of cardiac arrest, cardiogenic shock, and acute respiratory failure (ARF); shorter length of stay (LOS); and lower total charges (All p< 0.05). In-hospital mortality (p=0.102) and ventricular arrhythmia (p=0.235) rates did not differ. After propensity score matching, the HLD group had lower rates of in-hospital mortality (1.1% vs 2.4%, p=0.027), ARF (9.1% vs 12.1%, p = 0.022) and cardiogenic shock (3.4% vs 5.6%, p=0.012), shorter LOS (3.20 ± 3.27 days vs 3.57 ± 3.14 days, p=0.005), and lower total charges (p=0.013). The matched groups did not differ significantly regarding cardiac arrest (p=0.141), ventricular arrhythmia (p=0.662) or acute kidney injury (AKI) (p = 0.167).Conclusion: Counterintuitively, HLD was associated with better in-hospital outcomes in both the unmatched and propensity-matched cohorts of hospitalized TCM patients. Further studies are needed to investigate the mechanisms that may contribute to the association in TCM patients with HLD.Keywords: takotsubo cardiomyopathy, hyperlipidemia, mortality
format	article
author	Li P Lu X Teng C Hadley M Cai P Dai Q Wang B
author_facet	Li P Lu X Teng C Hadley M Cai P Dai Q Wang B
author_sort	Li P
title	The Association Between Hyperlipidemia and In-Hospital Outcomes in Takotsubo Cardiomyopathy
title_short	The Association Between Hyperlipidemia and In-Hospital Outcomes in Takotsubo Cardiomyopathy
title_full	The Association Between Hyperlipidemia and In-Hospital Outcomes in Takotsubo Cardiomyopathy
title_fullStr	The Association Between Hyperlipidemia and In-Hospital Outcomes in Takotsubo Cardiomyopathy
title_full_unstemmed	The Association Between Hyperlipidemia and In-Hospital Outcomes in Takotsubo Cardiomyopathy
title_sort	association between hyperlipidemia and in-hospital outcomes in takotsubo cardiomyopathy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c9b1e31be5ac4cb5bd9f40e31d19eb35
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The Association Between Hyperlipidemia and In-Hospital Outcomes in Takotsubo Cardiomyopathy

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