C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation

In ovarian cancer, the mechanism of chemoresistance is a key question. Here, the authors demonstrate that C/EBPβ and DOT1L together increase methylation of H3K79, which upregulates expression of oncogenic genes and drives poor platinum response and poor survival in ovarian cancer.

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Detalles Bibliográficos
Autores principales:	Dan Liu, Xiao-Xue Zhang, Meng-Chen Li, Can-Hui Cao, Dong-Yi Wan, Bi-Xin Xi, Jia-Hong Tan, Ji Wang, Zong-Yuan Yang, Xin-Xia Feng, Fei Ye, Gang Chen, Peng Wu, Ling Xi, Hui Wang, Jian-Feng Zhou, Zuo-Hua Feng, Ding Ma, Qing-Lei Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9b30596b94249a2a0f1f7ff2dd6da2e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:c9b30596b94249a2a0f1f7ff2dd6da2e2021-12-02T16:49:50ZC/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation10.1038/s41467-018-03590-52041-1723https://doaj.org/article/c9b30596b94249a2a0f1f7ff2dd6da2e2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03590-5https://doaj.org/toc/2041-1723In ovarian cancer, the mechanism of chemoresistance is a key question. Here, the authors demonstrate that C/EBPβ and DOT1L together increase methylation of H3K79, which upregulates expression of oncogenic genes and drives poor platinum response and poor survival in ovarian cancer.Dan LiuXiao-Xue ZhangMeng-Chen LiCan-Hui CaoDong-Yi WanBi-Xin XiJia-Hong TanJi WangZong-Yuan YangXin-Xia FengFei YeGang ChenPeng WuLing XiHui WangJian-Feng ZhouZuo-Hua FengDing MaQing-Lei GaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dan Liu Xiao-Xue Zhang Meng-Chen Li Can-Hui Cao Dong-Yi Wan Bi-Xin Xi Jia-Hong Tan Ji Wang Zong-Yuan Yang Xin-Xia Feng Fei Ye Gang Chen Peng Wu Ling Xi Hui Wang Jian-Feng Zhou Zuo-Hua Feng Ding Ma Qing-Lei Gao C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation
description	In ovarian cancer, the mechanism of chemoresistance is a key question. Here, the authors demonstrate that C/EBPβ and DOT1L together increase methylation of H3K79, which upregulates expression of oncogenic genes and drives poor platinum response and poor survival in ovarian cancer.
format	article
author	Dan Liu Xiao-Xue Zhang Meng-Chen Li Can-Hui Cao Dong-Yi Wan Bi-Xin Xi Jia-Hong Tan Ji Wang Zong-Yuan Yang Xin-Xia Feng Fei Ye Gang Chen Peng Wu Ling Xi Hui Wang Jian-Feng Zhou Zuo-Hua Feng Ding Ma Qing-Lei Gao
author_facet	Dan Liu Xiao-Xue Zhang Meng-Chen Li Can-Hui Cao Dong-Yi Wan Bi-Xin Xi Jia-Hong Tan Ji Wang Zong-Yuan Yang Xin-Xia Feng Fei Ye Gang Chen Peng Wu Ling Xi Hui Wang Jian-Feng Zhou Zuo-Hua Feng Ding Ma Qing-Lei Gao
author_sort	Dan Liu
title	C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation
title_short	C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation
title_full	C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation
title_fullStr	C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation
title_full_unstemmed	C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation
title_sort	c/ebpβ enhances platinum resistance of ovarian cancer cells by reprogramming h3k79 methylation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c9b30596b94249a2a0f1f7ff2dd6da2e
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C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation

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