C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation

QR Code

C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation

In ovarian cancer, the mechanism of chemoresistance is a key question. Here, the authors demonstrate that C/EBPβ and DOT1L together increase methylation of H3K79, which upregulates expression of oncogenic genes and drives poor platinum response and poor survival in ovarian cancer.

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Dan Liu, Xiao-Xue Zhang, Meng-Chen Li, Can-Hui Cao, Dong-Yi Wan, Bi-Xin Xi, Jia-Hong Tan, Ji Wang, Zong-Yuan Yang, Xin-Xia Feng, Fei Ye, Gang Chen, Peng Wu, Ling Xi, Hui Wang, Jian-Feng Zhou, Zuo-Hua Feng, Ding Ma, Qing-Lei Gao
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/c9b30596b94249a2a0f1f7ff2dd6da2e
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Platinum–copper single atom alloy catalysts with high performance towards glycerol hydrogenolysis
par: Xi Zhang, et autres
Publié: (2019)

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation
par: Laura Godfrey, et autres
Publié: (2019)

CEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1
par: You Jiang, et autres
Publié: (2021)

Long noncoding RNA expression signature to predict platinum-based chemotherapeutic sensitivity of ovarian cancer patients
par: Rong Liu, et autres
Publié: (2017)

Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation
par: Linjiao Zhou, et autres
Publié: (2016)

Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer
par: Ruogu Qi, et autres
Publié: (2017)

Acta No. 79
par: Banco Central de Chile
Publié: (2019)

Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys
par: Hui Peng, et autres
Publié: (2017)

Prediction of Key Candidate Genes for Platinum Resistance in Ovarian Cancer
par: Guo K, et autres
Publié: (2021)

Reprogramming of Histone H3 Lysine Methylation During Plant Sexual Reproduction
par: Huihui Fang, et autres
Publié: (2021)

Author Correction: Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer
par: Ruogu Qi, et autres
Publié: (2020)

Publisher Correction: Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer
par: Ruogu Qi, et autres
Publié: (2018)

The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse
par: Valérie Bégay, et autres
Publié: (2018)

Allele-specific induction of IL-1β expression by C/EBPβ and PU.1 contributes to increased tuberculosis susceptibility.
par: Guoliang Zhang, et autres
Publié: (2014)

CEPAL Review no.79
Publié: (2015)

Phase II trial of cisplatin, gemcitabine and pembrolizumab for platinum-resistant ovarian cancer.
par: Christine S Walsh, et autres
Publié: (2021)

Acetylation of C/EBPα inhibits its granulopoietic function
par: Deepak Bararia, et autres
Publié: (2016)

Oncolytic adenovirus inhibits malignant ascites of advanced ovarian cancer by reprogramming the ascitic immune microenvironment
par: Gang Shi, et autres
Publié: (2021)

Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
par: Hyoung Kim, et autres
Publié: (2020)

The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents
par: Tianzhen Wang, et autres
Publié: (2017)

Combination of gene set signatures correlates with response to nivolumab in platinum-resistant ovarian cancer
par: Ryusuke Murakami, et autres
Publié: (2021)

Common biological phenotypes characterize the acquisition of platinum-resistance in epithelial ovarian cancer cells
par: Maura Sonego, et autres
Publié: (2017)

Toll-like receptor 8: augmentation of innate immunity in platinum resistant ovarian carcinoma
par: Brueseke TJ, et autres
Publié: (2013)

Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects
par: Qin Zhang, et autres
Publié: (2018)

Revista de la CEPAL no.79
Publié: (2015)

PRMT3 promotes tumorigenesis by methylating and stabilizing HIF1α in colorectal cancer
par: Xin Zhang, et autres
Publié: (2021)

The TLR-2/TonEBP signaling pathway regulates 29-kDa fibronectin fragment-dependent expression of matrix metalloproteinases
par: Hyun Sook Hwang, et autres
Publié: (2021)

Analysing the Clinical Features of Pneumomediastinum Associated with Diabetic Ketoacidosis in 79 Cases
par: Zhang W, et autres
Publié: (2020)

C/EBPδ gene targets in human keratinocytes.
par: Serena Borrelli, et autres
Publié: (2010)

FOXF2 reprograms breast cancer cells into bone metastasis seeds
par: Shuo Wang, et autres
Publié: (2019)

Highly Expressed Progesterone Receptor B Isoform Increases Platinum Sensitivity and Survival of Ovarian High-Grade Serous Carcinoma
par: Hao Lin, et autres
Publié: (2021)

RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
par: Huilong Yin, et autres
Publié: (2021)

Molecular basis of AKAP79 regulation by calmodulin
par: Neha Patel, et autres
Publié: (2017)

Resolución 79(VI): Tendencias y perspectivas de la economía = Resolution 79(VI): Economic trends and prospects = Résolution 79(VI): Les tendances et les perspectives de l'économie
Publié: (2014)

Identification of Three Potential Prognostic Genes in Platinum-Resistant Ovarian Cancer via Integrated Bioinformatics Analysis
par: Zhang X, et autres
Publié: (2021)

CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents.
par: Yoshiko Oyama, et autres
Publié: (2021)

Comparison of the Efficacy and Safety of PARP Inhibitors as a Monotherapy for Platinum-Sensitive Recurrent Ovarian Cancer: A Network Meta-Analysis
par: Hongmei Wang, et autres
Publié: (2021)

ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
par: Chi-Lam Au-Yeung, et autres
Publié: (2020)

High Serpin Family A Member 10 Expression Confers Platinum Sensitivity and Is Associated With Survival Benefit in High-Grade Serous Ovarian Cancer: Based on Quantitative Proteomic Analysis
par: Wenwen Guo, et autres
Publié: (2021)

Platinum covalent shell cross-linked micelles designed to deliver doxorubicin for synergistic combination cancer therapy
par: Zhu CY, et autres
Publié: (2017)