Graphene-based nanovehicles for photodynamic medical therapy

Yan Li,1 Haiqing Dong,1 Yongyong Li,1 Donglu Shi1,2 1Shanghai East Hospital, The Institute for Biomedical Engineering and Nano Science (iNANO), Tongji University School of Medicine, Shanghai, People’s Republic of China; 2The Materials Science and Engineering Program, Department of Mechan...

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Autores principales:	Li Y, Dong H, Shi D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c9b33348e2a64942a5b8b8d97aa36d3b
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spelling	oai:doaj.org-article:c9b33348e2a64942a5b8b8d97aa36d3b2021-12-02T05:10:45ZGraphene-based nanovehicles for photodynamic medical therapy1178-2013https://doaj.org/article/c9b33348e2a64942a5b8b8d97aa36d3b2015-03-01T00:00:00Zhttp://www.dovepress.com/graphene-based-nanovehicles-for-photodynamic-medical-therapy-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Yan Li,1 Haiqing Dong,1 Yongyong Li,1 Donglu Shi1,2 1Shanghai East Hospital, The Institute for Biomedical Engineering and Nano Science (iNANO), Tongji University School of Medicine, Shanghai, People’s Republic of China; 2The Materials Science and Engineering Program, Department of Mechanical and Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH, USA Abstract: Graphene and its derivatives such as graphene oxide (GO) have been widely explored as promising drug delivery vehicles for improved cancer treatment. In this review, we focus on their applications in photodynamic therapy. The large specific surface area of GO facilitates efficient loading of the photosensitizers and biological molecules via various surface functional groups. By incorporation of targeting ligands or activatable agents responsive to specific biological stimulations, smart nanovehicles are established, enabling tumor-triggering release or tumor-selective accumulation of photosensitizer for effective therapy with minimum side effects. Graphene-based nanosystems have been shown to improve the stability, bioavailability, and photodynamic efficiency of organic photosensitizer molecules. They have also been shown to behave as electron sinks for enhanced visible-light photodynamic activities. Owing to its intrinsic near infrared absorption properties, GO can be designed to combine both photodynamic and photothermal hyperthermia for optimum therapeutic efficiency. Critical issues and future aspects of photodynamic therapy research are addressed in this review. Keywords: graphene, nanovehicle, photodynamic therapy, photosensitizer, hyperthermiaLi YDong HLi YShi DDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 2451-2459 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Li Y Dong H Li Y Shi D Graphene-based nanovehicles for photodynamic medical therapy
description	Yan Li,1 Haiqing Dong,1 Yongyong Li,1 Donglu Shi1,2 1Shanghai East Hospital, The Institute for Biomedical Engineering and Nano Science (iNANO), Tongji University School of Medicine, Shanghai, People’s Republic of China; 2The Materials Science and Engineering Program, Department of Mechanical and Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH, USA Abstract: Graphene and its derivatives such as graphene oxide (GO) have been widely explored as promising drug delivery vehicles for improved cancer treatment. In this review, we focus on their applications in photodynamic therapy. The large specific surface area of GO facilitates efficient loading of the photosensitizers and biological molecules via various surface functional groups. By incorporation of targeting ligands or activatable agents responsive to specific biological stimulations, smart nanovehicles are established, enabling tumor-triggering release or tumor-selective accumulation of photosensitizer for effective therapy with minimum side effects. Graphene-based nanosystems have been shown to improve the stability, bioavailability, and photodynamic efficiency of organic photosensitizer molecules. They have also been shown to behave as electron sinks for enhanced visible-light photodynamic activities. Owing to its intrinsic near infrared absorption properties, GO can be designed to combine both photodynamic and photothermal hyperthermia for optimum therapeutic efficiency. Critical issues and future aspects of photodynamic therapy research are addressed in this review. Keywords: graphene, nanovehicle, photodynamic therapy, photosensitizer, hyperthermia
format	article
author	Li Y Dong H Li Y Shi D
author_facet	Li Y Dong H Li Y Shi D
author_sort	Li Y
title	Graphene-based nanovehicles for photodynamic medical therapy
title_short	Graphene-based nanovehicles for photodynamic medical therapy
title_full	Graphene-based nanovehicles for photodynamic medical therapy
title_fullStr	Graphene-based nanovehicles for photodynamic medical therapy
title_full_unstemmed	Graphene-based nanovehicles for photodynamic medical therapy
title_sort	graphene-based nanovehicles for photodynamic medical therapy
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/c9b33348e2a64942a5b8b8d97aa36d3b
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Graphene-based nanovehicles for photodynamic medical therapy

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