ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress

ATRX is a chromatin remodeling protein, which loss has been associated to replication stress, DNA damage, and DNA repair failures that drive genome instability. Here the authors reveal that ATRX protects genomic integrity at G4-containing regions by maintaining these regions in a closed heterochroma...

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Autores principales: Yu-Ching Teng, Aishwarya Sundaresan, Ryan O’Hara, Vincent U. Gant, Minhua Li, Sara Martire, Jane N. Warshaw, Amrita Basu, Laura A. Banaszynski
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c9b46c0c43fd49e8b61774788526fb9b
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Sumario:ATRX is a chromatin remodeling protein, which loss has been associated to replication stress, DNA damage, and DNA repair failures that drive genome instability. Here the authors reveal that ATRX protects genomic integrity at G4-containing regions by maintaining these regions in a closed heterochromatic state.