ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress

ATRX is a chromatin remodeling protein, which loss has been associated to replication stress, DNA damage, and DNA repair failures that drive genome instability. Here the authors reveal that ATRX protects genomic integrity at G4-containing regions by maintaining these regions in a closed heterochroma...

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Autores principales: Yu-Ching Teng, Aishwarya Sundaresan, Ryan O’Hara, Vincent U. Gant, Minhua Li, Sara Martire, Jane N. Warshaw, Amrita Basu, Laura A. Banaszynski
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c9b46c0c43fd49e8b61774788526fb9b
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spelling oai:doaj.org-article:c9b46c0c43fd49e8b61774788526fb9b2021-12-02T17:44:52ZATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress10.1038/s41467-021-24206-52041-1723https://doaj.org/article/c9b46c0c43fd49e8b61774788526fb9b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24206-5https://doaj.org/toc/2041-1723ATRX is a chromatin remodeling protein, which loss has been associated to replication stress, DNA damage, and DNA repair failures that drive genome instability. Here the authors reveal that ATRX protects genomic integrity at G4-containing regions by maintaining these regions in a closed heterochromatic state.Yu-Ching TengAishwarya SundaresanRyan O’HaraVincent U. GantMinhua LiSara MartireJane N. WarshawAmrita BasuLaura A. BanaszynskiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yu-Ching Teng
Aishwarya Sundaresan
Ryan O’Hara
Vincent U. Gant
Minhua Li
Sara Martire
Jane N. Warshaw
Amrita Basu
Laura A. Banaszynski
ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
description ATRX is a chromatin remodeling protein, which loss has been associated to replication stress, DNA damage, and DNA repair failures that drive genome instability. Here the authors reveal that ATRX protects genomic integrity at G4-containing regions by maintaining these regions in a closed heterochromatic state.
format article
author Yu-Ching Teng
Aishwarya Sundaresan
Ryan O’Hara
Vincent U. Gant
Minhua Li
Sara Martire
Jane N. Warshaw
Amrita Basu
Laura A. Banaszynski
author_facet Yu-Ching Teng
Aishwarya Sundaresan
Ryan O’Hara
Vincent U. Gant
Minhua Li
Sara Martire
Jane N. Warshaw
Amrita Basu
Laura A. Banaszynski
author_sort Yu-Ching Teng
title ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
title_short ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
title_full ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
title_fullStr ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
title_full_unstemmed ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
title_sort atrx promotes heterochromatin formation to protect cells from g-quadruplex dna-mediated stress
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c9b46c0c43fd49e8b61774788526fb9b
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