ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress

ATRX is a chromatin remodeling protein, which loss has been associated to replication stress, DNA damage, and DNA repair failures that drive genome instability. Here the authors reveal that ATRX protects genomic integrity at G4-containing regions by maintaining these regions in a closed heterochroma...

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Main Authors:	Yu-Ching Teng, Aishwarya Sundaresan, Ryan O’Hara, Vincent U. Gant, Minhua Li, Sara Martire, Jane N. Warshaw, Amrita Basu, Laura A. Banaszynski
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/c9b46c0c43fd49e8b61774788526fb9b
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spelling	oai:doaj.org-article:c9b46c0c43fd49e8b61774788526fb9b2021-12-02T17:44:52ZATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress10.1038/s41467-021-24206-52041-1723https://doaj.org/article/c9b46c0c43fd49e8b61774788526fb9b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24206-5https://doaj.org/toc/2041-1723ATRX is a chromatin remodeling protein, which loss has been associated to replication stress, DNA damage, and DNA repair failures that drive genome instability. Here the authors reveal that ATRX protects genomic integrity at G4-containing regions by maintaining these regions in a closed heterochromatic state.Yu-Ching TengAishwarya SundaresanRyan O’HaraVincent U. GantMinhua LiSara MartireJane N. WarshawAmrita BasuLaura A. BanaszynskiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu-Ching Teng Aishwarya Sundaresan Ryan O’Hara Vincent U. Gant Minhua Li Sara Martire Jane N. Warshaw Amrita Basu Laura A. Banaszynski ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
description	ATRX is a chromatin remodeling protein, which loss has been associated to replication stress, DNA damage, and DNA repair failures that drive genome instability. Here the authors reveal that ATRX protects genomic integrity at G4-containing regions by maintaining these regions in a closed heterochromatic state.
format	article
author	Yu-Ching Teng Aishwarya Sundaresan Ryan O’Hara Vincent U. Gant Minhua Li Sara Martire Jane N. Warshaw Amrita Basu Laura A. Banaszynski
author_facet	Yu-Ching Teng Aishwarya Sundaresan Ryan O’Hara Vincent U. Gant Minhua Li Sara Martire Jane N. Warshaw Amrita Basu Laura A. Banaszynski
author_sort	Yu-Ching Teng
title	ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
title_short	ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
title_full	ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
title_fullStr	ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
title_full_unstemmed	ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
title_sort	atrx promotes heterochromatin formation to protect cells from g-quadruplex dna-mediated stress
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9b46c0c43fd49e8b61774788526fb9b
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ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress

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