Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

In breast cancer, dormant cancer cells may develop into bone metastases. Here, the authors demonstrate that microenvironmental IL1β stimulates metastatic breast cancer cell colonisation in the bone via IL1β-NFKB/CREB-Wnt pathway activation and cancer stem cell colony formation

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Autores principales:	Rachel Eyre, Denis G. Alférez, Angélica Santiago-Gómez, Kath Spence, James C. McConnell, Claire Hart, Bruno M. Simões, Diane Lefley, Claudia Tulotta, Joanna Storer, Austin Gurney, Noel Clarke, Mick Brown, Sacha J. Howell, Andrew H. Sims, Gillian Farnie, Penelope D. Ottewell, Robert B. Clarke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9b7748a363e46eb80d945fea7c4be66
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spelling	oai:doaj.org-article:c9b7748a363e46eb80d945fea7c4be662021-12-02T17:02:07ZMicroenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling10.1038/s41467-019-12807-02041-1723https://doaj.org/article/c9b7748a363e46eb80d945fea7c4be662019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12807-0https://doaj.org/toc/2041-1723In breast cancer, dormant cancer cells may develop into bone metastases. Here, the authors demonstrate that microenvironmental IL1β stimulates metastatic breast cancer cell colonisation in the bone via IL1β-NFKB/CREB-Wnt pathway activation and cancer stem cell colony formationRachel EyreDenis G. AlférezAngélica Santiago-GómezKath SpenceJames C. McConnellClaire HartBruno M. SimõesDiane LefleyClaudia TulottaJoanna StorerAustin GurneyNoel ClarkeMick BrownSacha J. HowellAndrew H. SimsGillian FarniePenelope D. OttewellRobert B. ClarkeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rachel Eyre Denis G. Alférez Angélica Santiago-Gómez Kath Spence James C. McConnell Claire Hart Bruno M. Simões Diane Lefley Claudia Tulotta Joanna Storer Austin Gurney Noel Clarke Mick Brown Sacha J. Howell Andrew H. Sims Gillian Farnie Penelope D. Ottewell Robert B. Clarke Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
description	In breast cancer, dormant cancer cells may develop into bone metastases. Here, the authors demonstrate that microenvironmental IL1β stimulates metastatic breast cancer cell colonisation in the bone via IL1β-NFKB/CREB-Wnt pathway activation and cancer stem cell colony formation
format	article
author	Rachel Eyre Denis G. Alférez Angélica Santiago-Gómez Kath Spence James C. McConnell Claire Hart Bruno M. Simões Diane Lefley Claudia Tulotta Joanna Storer Austin Gurney Noel Clarke Mick Brown Sacha J. Howell Andrew H. Sims Gillian Farnie Penelope D. Ottewell Robert B. Clarke
author_facet	Rachel Eyre Denis G. Alférez Angélica Santiago-Gómez Kath Spence James C. McConnell Claire Hart Bruno M. Simões Diane Lefley Claudia Tulotta Joanna Storer Austin Gurney Noel Clarke Mick Brown Sacha J. Howell Andrew H. Sims Gillian Farnie Penelope D. Ottewell Robert B. Clarke
author_sort	Rachel Eyre
title	Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
title_short	Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
title_full	Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
title_fullStr	Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
title_full_unstemmed	Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
title_sort	microenvironmental il1β promotes breast cancer metastatic colonisation in the bone via activation of wnt signalling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c9b7748a363e46eb80d945fea7c4be66
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Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

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