Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

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Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

In breast cancer, dormant cancer cells may develop into bone metastases. Here, the authors demonstrate that microenvironmental IL1β stimulates metastatic breast cancer cell colonisation in the bone via IL1β-NFKB/CREB-Wnt pathway activation and cancer stem cell colony formation

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Détails bibliographiques
Auteurs principaux:	Rachel Eyre, Denis G. Alférez, Angélica Santiago-Gómez, Kath Spence, James C. McConnell, Claire Hart, Bruno M. Simões, Diane Lefley, Claudia Tulotta, Joanna Storer, Austin Gurney, Noel Clarke, Mick Brown, Sacha J. Howell, Andrew H. Sims, Gillian Farnie, Penelope D. Ottewell, Robert B. Clarke
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/c9b7748a363e46eb80d945fea7c4be66
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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