METTL3-dependent m6A modification programs T follicular helper cell differentiation

METTL3-dependent m6A modification programs T follicular helper cell differentiation

T follicular helper (TFH) cells are specialized effector CD4+ T cells that are critical in humoral immunity, but the function of post-transcriptional regulation is not clearly defined. Here, the authors demonstrate that RNA methylation is important for TFH effector differentiation and subsequent ant...

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Main Authors: Yingpeng Yao, Ying Yang, Wenhui Guo, Lifan Xu, Menghao You, Yi-Chang Zhang, Zhen Sun, Xiao Cui, Guotao Yu, Zhihong Qi, Jingjing Liu, Fang Wang, Juanjuan Liu, Tianyan Zhao, Lilin Ye, Yun-Gui Yang, Shuyang Yu
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/c9bcc1a4d92f4f9192c2a0c829e54fdb
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Summary:T follicular helper (TFH) cells are specialized effector CD4+ T cells that are critical in humoral immunity, but the function of post-transcriptional regulation is not clearly defined. Here, the authors demonstrate that RNA methylation is important for TFH effector differentiation and subsequent antibody formation through stabilization of Tcf7 transcripts.

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