METTL3-dependent m6A modification programs T follicular helper cell differentiation

METTL3-dependent m6A modification programs T follicular helper cell differentiation

T follicular helper (TFH) cells are specialized effector CD4+ T cells that are critical in humoral immunity, but the function of post-transcriptional regulation is not clearly defined. Here, the authors demonstrate that RNA methylation is important for TFH effector differentiation and subsequent ant...

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Autores principales: Yingpeng Yao, Ying Yang, Wenhui Guo, Lifan Xu, Menghao You, Yi-Chang Zhang, Zhen Sun, Xiao Cui, Guotao Yu, Zhihong Qi, Jingjing Liu, Fang Wang, Juanjuan Liu, Tianyan Zhao, Lilin Ye, Yun-Gui Yang, Shuyang Yu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c9bcc1a4d92f4f9192c2a0c829e54fdb
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spelling oai:doaj.org-article:c9bcc1a4d92f4f9192c2a0c829e54fdb2021-12-02T13:33:01ZMETTL3-dependent m6A modification programs T follicular helper cell differentiation10.1038/s41467-021-21594-62041-1723https://doaj.org/article/c9bcc1a4d92f4f9192c2a0c829e54fdb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21594-6https://doaj.org/toc/2041-1723T follicular helper (TFH) cells are specialized effector CD4+ T cells that are critical in humoral immunity, but the function of post-transcriptional regulation is not clearly defined. Here, the authors demonstrate that RNA methylation is important for TFH effector differentiation and subsequent antibody formation through stabilization of Tcf7 transcripts.Yingpeng YaoYing YangWenhui GuoLifan XuMenghao YouYi-Chang ZhangZhen SunXiao CuiGuotao YuZhihong QiJingjing LiuFang WangJuanjuan LiuTianyan ZhaoLilin YeYun-Gui YangShuyang YuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yingpeng Yao
Ying Yang
Wenhui Guo
Lifan Xu
Menghao You
Yi-Chang Zhang
Zhen Sun
Xiao Cui
Guotao Yu
Zhihong Qi
Jingjing Liu
Fang Wang
Juanjuan Liu
Tianyan Zhao
Lilin Ye
Yun-Gui Yang
Shuyang Yu
METTL3-dependent m6A modification programs T follicular helper cell differentiation
description T follicular helper (TFH) cells are specialized effector CD4+ T cells that are critical in humoral immunity, but the function of post-transcriptional regulation is not clearly defined. Here, the authors demonstrate that RNA methylation is important for TFH effector differentiation and subsequent antibody formation through stabilization of Tcf7 transcripts.
format article
author Yingpeng Yao
Ying Yang
Wenhui Guo
Lifan Xu
Menghao You
Yi-Chang Zhang
Zhen Sun
Xiao Cui
Guotao Yu
Zhihong Qi
Jingjing Liu
Fang Wang
Juanjuan Liu
Tianyan Zhao
Lilin Ye
Yun-Gui Yang
Shuyang Yu
author_facet Yingpeng Yao
Ying Yang
Wenhui Guo
Lifan Xu
Menghao You
Yi-Chang Zhang
Zhen Sun
Xiao Cui
Guotao Yu
Zhihong Qi
Jingjing Liu
Fang Wang
Juanjuan Liu
Tianyan Zhao
Lilin Ye
Yun-Gui Yang
Shuyang Yu
author_sort Yingpeng Yao
title METTL3-dependent m6A modification programs T follicular helper cell differentiation
title_short METTL3-dependent m6A modification programs T follicular helper cell differentiation
title_full METTL3-dependent m6A modification programs T follicular helper cell differentiation
title_fullStr METTL3-dependent m6A modification programs T follicular helper cell differentiation
title_full_unstemmed METTL3-dependent m6A modification programs T follicular helper cell differentiation
title_sort mettl3-dependent m6a modification programs t follicular helper cell differentiation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c9bcc1a4d92f4f9192c2a0c829e54fdb
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