Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase.

The APOBEC3 proteins form a multigene family of cytidine deaminases with inhibitory activity against viruses and retrotransposons. In contrast to APOBEC3G (A3G), APOBEC3A (A3A) has no effect on lentiviruses but dramatically inhibits replication of the parvovirus adeno-associated virus (AAV). To stud...

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Autores principales: Iñigo Narvaiza, Daniel C Linfesty, Benjamin N Greener, Yoshiyuki Hakata, David J Pintel, Eric Logue, Nathaniel R Landau, Matthew D Weitzman
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
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Acceso en línea:https://doaj.org/article/c9be6e30441e4dc4b3b23d56c804e04b
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