Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview

The present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides. However, regardless of the differences in the l...

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Autores principales:	Lestanova Z., Bacova Z., Bakos Jan
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	oxytocin neurite outgrowth phosphatidylinositol-calcium system cdc42 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/c9c2d3d1123d49bcbeb59f26b3892854
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spelling	oai:doaj.org-article:c9c2d3d1123d49bcbeb59f26b38928542021-12-02T19:10:34ZMechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview1336-032910.1515/enr-2016-0011https://doaj.org/article/c9c2d3d1123d49bcbeb59f26b38928542016-04-01T00:00:00Zhttps://doi.org/10.1515/enr-2016-0011https://doaj.org/toc/1336-0329The present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides. However, regardless of the differences in the local responses elicited by neuropeptides, there exist certain functional similarities in the effects of neuropeptides, mediated by their receptors. In the present review, data of the relevant studies, focused on G protein-coupled receptors activated by neuropeptides, are summarized. Particularly, receptors that activate phosphatidylinositol-calcium system and protein kinase C pathways, resulting in the reorganization of the neuronal cytoskeleton and changes in the neuronal morphology, are discussed. Based on our data received, we are showing that oxytocin increases the gene expression of GTPase cell division cycle protein 42 (Cdc42), implicated in many aspects of the neuronal growth and morphology. We are also paying a special attention to neurite extension and retraction in the context of neuropeptide regulation.Lestanova Z.Bacova Z.Bakos JanSciendoarticleoxytocinneurite outgrowthphosphatidylinositol-calcium systemcdc42Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 50, Iss 2, Pp 72-82 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxytocin neurite outgrowth phosphatidylinositol-calcium system cdc42 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	oxytocin neurite outgrowth phosphatidylinositol-calcium system cdc42 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Lestanova Z. Bacova Z. Bakos Jan Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview
description	The present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides. However, regardless of the differences in the local responses elicited by neuropeptides, there exist certain functional similarities in the effects of neuropeptides, mediated by their receptors. In the present review, data of the relevant studies, focused on G protein-coupled receptors activated by neuropeptides, are summarized. Particularly, receptors that activate phosphatidylinositol-calcium system and protein kinase C pathways, resulting in the reorganization of the neuronal cytoskeleton and changes in the neuronal morphology, are discussed. Based on our data received, we are showing that oxytocin increases the gene expression of GTPase cell division cycle protein 42 (Cdc42), implicated in many aspects of the neuronal growth and morphology. We are also paying a special attention to neurite extension and retraction in the context of neuropeptide regulation.
format	article
author	Lestanova Z. Bacova Z. Bakos Jan
author_facet	Lestanova Z. Bacova Z. Bakos Jan
author_sort	Lestanova Z.
title	Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview
title_short	Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview
title_full	Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview
title_fullStr	Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview
title_full_unstemmed	Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview
title_sort	mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/c9c2d3d1123d49bcbeb59f26b3892854
work_keys_str_mv	AT lestanovaz mechanismsinvolvedintheregulationofneuropeptidemediatedneuriteoutgrowthaminireview AT bacovaz mechanismsinvolvedintheregulationofneuropeptidemediatedneuriteoutgrowthaminireview AT bakosjan mechanismsinvolvedintheregulationofneuropeptidemediatedneuriteoutgrowthaminireview
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Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview

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