Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish

The neural crest (NC) is a multipotent cell population in vertebrate embryos with extraordinary migratory capacity. The NC is crucial for vertebrate development and forms a myriad of cell derivatives throughout the body, including pigment cells, neuronal cells of the peripheral nervous system, cardi...

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Autores principales:	Gemma Sutton, Robert N. Kelsh, Steffen Scholpp
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Wnt/β-catenin signalling neural crest gene regulatory network NC induction NC specification pigment cells Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c9c3d23e287d4381b5046650243157d8
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spelling	oai:doaj.org-article:c9c3d23e287d4381b5046650243157d82021-12-01T13:41:00ZReview: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish2296-634X10.3389/fcell.2021.782445https://doaj.org/article/c9c3d23e287d4381b5046650243157d82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.782445/fullhttps://doaj.org/toc/2296-634XThe neural crest (NC) is a multipotent cell population in vertebrate embryos with extraordinary migratory capacity. The NC is crucial for vertebrate development and forms a myriad of cell derivatives throughout the body, including pigment cells, neuronal cells of the peripheral nervous system, cardiomyocytes and skeletogenic cells in craniofacial tissue. NC induction occurs at the end of gastrulation when the multipotent population of NC progenitors emerges in the ectodermal germ layer in the neural plate border region. In the process of NC fate specification, fate-specific markers are expressed in multipotent progenitors, which subsequently adopt a specific fate. Thus, NC cells delaminate from the neural plate border and migrate extensively throughout the embryo until they differentiate into various cell derivatives. Multiple signalling pathways regulate the processes of NC induction and specification. This review explores the ongoing role of the Wnt/β-catenin signalling pathway during NC development, focusing on research undertaken in the Teleost model organism, zebrafish (Danio rerio). We discuss the function of the Wnt/β-catenin signalling pathway in inducing the NC within the neural plate border and the specification of melanocytes from the NC. The current understanding of NC development suggests a continual role of Wnt/β-catenin signalling in activating and maintaining the gene regulatory network during NC induction and pigment cell specification. We relate this to emerging models and hypotheses on NC fate restriction. Finally, we highlight the ongoing challenges facing NC research, current gaps in knowledge, and this field’s potential future directions.Gemma SuttonRobert N. KelshSteffen ScholppFrontiers Media S.A.articleWnt/β-catenin signallingneural crestgene regulatory networkNC inductionNC specificationpigment cellsBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Wnt/β-catenin signalling neural crest gene regulatory network NC induction NC specification pigment cells Biology (General) QH301-705.5
spellingShingle	Wnt/β-catenin signalling neural crest gene regulatory network NC induction NC specification pigment cells Biology (General) QH301-705.5 Gemma Sutton Robert N. Kelsh Steffen Scholpp Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
description	The neural crest (NC) is a multipotent cell population in vertebrate embryos with extraordinary migratory capacity. The NC is crucial for vertebrate development and forms a myriad of cell derivatives throughout the body, including pigment cells, neuronal cells of the peripheral nervous system, cardiomyocytes and skeletogenic cells in craniofacial tissue. NC induction occurs at the end of gastrulation when the multipotent population of NC progenitors emerges in the ectodermal germ layer in the neural plate border region. In the process of NC fate specification, fate-specific markers are expressed in multipotent progenitors, which subsequently adopt a specific fate. Thus, NC cells delaminate from the neural plate border and migrate extensively throughout the embryo until they differentiate into various cell derivatives. Multiple signalling pathways regulate the processes of NC induction and specification. This review explores the ongoing role of the Wnt/β-catenin signalling pathway during NC development, focusing on research undertaken in the Teleost model organism, zebrafish (Danio rerio). We discuss the function of the Wnt/β-catenin signalling pathway in inducing the NC within the neural plate border and the specification of melanocytes from the NC. The current understanding of NC development suggests a continual role of Wnt/β-catenin signalling in activating and maintaining the gene regulatory network during NC induction and pigment cell specification. We relate this to emerging models and hypotheses on NC fate restriction. Finally, we highlight the ongoing challenges facing NC research, current gaps in knowledge, and this field’s potential future directions.
format	article
author	Gemma Sutton Robert N. Kelsh Steffen Scholpp
author_facet	Gemma Sutton Robert N. Kelsh Steffen Scholpp
author_sort	Gemma Sutton
title	Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
title_short	Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
title_full	Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
title_fullStr	Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
title_full_unstemmed	Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
title_sort	review: the role of wnt/β-catenin signalling in neural crest development in zebrafish
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c9c3d23e287d4381b5046650243157d8
work_keys_str_mv	AT gemmasutton reviewtheroleofwntbcateninsignallinginneuralcrestdevelopmentinzebrafish AT robertnkelsh reviewtheroleofwntbcateninsignallinginneuralcrestdevelopmentinzebrafish AT steffenscholpp reviewtheroleofwntbcateninsignallinginneuralcrestdevelopmentinzebrafish
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Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish

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