MYSTERY OF iAMP

Objective: Intrachromosomal amplification of chromosome 21 (iAMP21) is defined as the presence of three or more RUNX1 signals on a single chromosome, or a total of five or more RUNX1 signals per cell. It occurs in 2% of pediatric B-cell acute lymphoblastic leukemia (ALL), but is associated with olde...

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Autores principales:	Fatma Burçin KURTİPEK, Dilek KAÇAR, Ebru TUNÇEZ, Melek IŞIK, Neşe YARALI
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/c9c61f0e417f4c0d8ab14cdbfe8bc9c8
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id	oai:doaj.org-article:c9c61f0e417f4c0d8ab14cdbfe8bc9c8
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spelling	oai:doaj.org-article:c9c61f0e417f4c0d8ab14cdbfe8bc9c82021-11-10T04:33:36ZMYSTERY OF iAMP2531-137910.1016/j.htct.2021.10.994https://doaj.org/article/c9c61f0e417f4c0d8ab14cdbfe8bc9c82021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S253113792101141Xhttps://doaj.org/toc/2531-1379Objective: Intrachromosomal amplification of chromosome 21 (iAMP21) is defined as the presence of three or more RUNX1 signals on a single chromosome, or a total of five or more RUNX1 signals per cell. It occurs in 2% of pediatric B-cell acute lymphoblastic leukemia (ALL), but is associated with older age, low white blood cell count, and high risk of relapse.In our study, it was aimed to review our patients with ALL in terms of possible iAMP21 at the time of diagnosis and to evaluate the clinical features. Methodology: The results of the patients who were diagnosed with B-cell ALL between 2012 and 2019 and whose treatment was completed, and whose signal increase in the RUNX1 region in the t(12;21) FISH analysis were detected, were reviewed together with the medical genetics section in terms of possible i amp. Those with 5 or more signal increases on a single gene in RUNX1 were considered as i amp. Results: In the t(12;21) FISH analysis, signal increases were observed in the RUNX 1 region in 15 (8.3%) of 180 B-cell ALL patients included in the study. Although these signal increases varied between 3-4 in 14 patients, 4-7 signal increases were detected in only 1 patient and were considered as iamp. The patient with iamp was a 6-year-old patient with a white blood cell count of 7600/mm3 at presentation and followed in the intermediate risk group. . Bone marrow relapse developed in 2 years. Conclusion: The presence of iAMP21 is associated with a delay in treatment response and increased recurrence in the late period. Patients should be carefully evaluated for iAMP21.Fatma Burçin KURTİPEKDilek KAÇAREbru TUNÇEZMelek IŞIKNeşe YARALIElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S25-S26 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Fatma Burçin KURTİPEK Dilek KAÇAR Ebru TUNÇEZ Melek IŞIK Neşe YARALI MYSTERY OF iAMP
description	Objective: Intrachromosomal amplification of chromosome 21 (iAMP21) is defined as the presence of three or more RUNX1 signals on a single chromosome, or a total of five or more RUNX1 signals per cell. It occurs in 2% of pediatric B-cell acute lymphoblastic leukemia (ALL), but is associated with older age, low white blood cell count, and high risk of relapse.In our study, it was aimed to review our patients with ALL in terms of possible iAMP21 at the time of diagnosis and to evaluate the clinical features. Methodology: The results of the patients who were diagnosed with B-cell ALL between 2012 and 2019 and whose treatment was completed, and whose signal increase in the RUNX1 region in the t(12;21) FISH analysis were detected, were reviewed together with the medical genetics section in terms of possible i amp. Those with 5 or more signal increases on a single gene in RUNX1 were considered as i amp. Results: In the t(12;21) FISH analysis, signal increases were observed in the RUNX 1 region in 15 (8.3%) of 180 B-cell ALL patients included in the study. Although these signal increases varied between 3-4 in 14 patients, 4-7 signal increases were detected in only 1 patient and were considered as iamp. The patient with iamp was a 6-year-old patient with a white blood cell count of 7600/mm3 at presentation and followed in the intermediate risk group. . Bone marrow relapse developed in 2 years. Conclusion: The presence of iAMP21 is associated with a delay in treatment response and increased recurrence in the late period. Patients should be carefully evaluated for iAMP21.
format	article
author	Fatma Burçin KURTİPEK Dilek KAÇAR Ebru TUNÇEZ Melek IŞIK Neşe YARALI
author_facet	Fatma Burçin KURTİPEK Dilek KAÇAR Ebru TUNÇEZ Melek IŞIK Neşe YARALI
author_sort	Fatma Burçin KURTİPEK
title	MYSTERY OF iAMP
title_short	MYSTERY OF iAMP
title_full	MYSTERY OF iAMP
title_fullStr	MYSTERY OF iAMP
title_full_unstemmed	MYSTERY OF iAMP
title_sort	mystery of iamp
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c9c61f0e417f4c0d8ab14cdbfe8bc9c8
work_keys_str_mv	AT fatmaburcinkurtipek mysteryofiamp AT dilekkacar mysteryofiamp AT ebrutuncez mysteryofiamp AT melekisik mysteryofiamp AT neseyarali mysteryofiamp
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MYSTERY OF iAMP

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