Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

Natural compounds restore NAD+ levels in humans It’s possible to boost declining levels of NAD+, a molecule required for fundamental chemical reactions in the human body, with a dietary supplement. A team led by Leonard Guarente of MIT and Elysium Health gave 120 healthy adult volunteers between the...

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Autores principales:	Ryan W. Dellinger, Santiago Roel Santos, Mark Morris, Mal Evans, Dan Alminana, Leonard Guarente, Eric Marcotulli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/c9c6dce4ca46420d81951a70d59bed5b
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spelling	oai:doaj.org-article:c9c6dce4ca46420d81951a70d59bed5b2021-12-02T13:41:46ZRepeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study10.1038/s41514-017-0016-92056-3973https://doaj.org/article/c9c6dce4ca46420d81951a70d59bed5b2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0016-9https://doaj.org/toc/2056-3973Natural compounds restore NAD+ levels in humans It’s possible to boost declining levels of NAD+, a molecule required for fundamental chemical reactions in the human body, with a dietary supplement. A team led by Leonard Guarente of MIT and Elysium Health gave 120 healthy adult volunteers between the ages of 60 and 80 NRPT (known commercially as Basis) over the course of eight weeks. Volunteers taking the regular dose of NRPT had 40 percent more NAD+ compared to their baseline when tested at four weeks and at eight weeks. Others who took a double dose of NRPT had even higher levels of NAD+, while those who took the placebo saw no increase. Research shows that NAD+ levels decline in animals and humans with age. Boosting NAD+ in animals improves age-associated diseases, so researchers now want to understand whether humans, too, may benefit.Ryan W. DellingerSantiago Roel SantosMark MorrisMal EvansDan AlminanaLeonard GuarenteEric MarcotulliNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Ryan W. Dellinger Santiago Roel Santos Mark Morris Mal Evans Dan Alminana Leonard Guarente Eric Marcotulli Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
description	Natural compounds restore NAD+ levels in humans It’s possible to boost declining levels of NAD+, a molecule required for fundamental chemical reactions in the human body, with a dietary supplement. A team led by Leonard Guarente of MIT and Elysium Health gave 120 healthy adult volunteers between the ages of 60 and 80 NRPT (known commercially as Basis) over the course of eight weeks. Volunteers taking the regular dose of NRPT had 40 percent more NAD+ compared to their baseline when tested at four weeks and at eight weeks. Others who took a double dose of NRPT had even higher levels of NAD+, while those who took the placebo saw no increase. Research shows that NAD+ levels decline in animals and humans with age. Boosting NAD+ in animals improves age-associated diseases, so researchers now want to understand whether humans, too, may benefit.
format	article
author	Ryan W. Dellinger Santiago Roel Santos Mark Morris Mal Evans Dan Alminana Leonard Guarente Eric Marcotulli
author_facet	Ryan W. Dellinger Santiago Roel Santos Mark Morris Mal Evans Dan Alminana Leonard Guarente Eric Marcotulli
author_sort	Ryan W. Dellinger
title	Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
title_short	Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
title_full	Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
title_fullStr	Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
title_full_unstemmed	Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
title_sort	repeat dose nrpt (nicotinamide riboside and pterostilbene) increases nad+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c9c6dce4ca46420d81951a70d59bed5b
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Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

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